Human leukocyte antigens as genetic markers in colorectal carcinoma

Abstract

The observation of specific human leukocyte antigen associations with particular subsets of colorectal cancer strongly suggests that genetic susceptibility for the development of colorectal cancer exists. Although the multifactorial pathogenesis of colorectal cancer must be considered, human leukocyte antigens may have useful predictive and diagnostic value.

The bodies fight against cancer: is human leucocyte antigen (HLA) class 1 the key?

“…On closer inspection, 13 papers did not provide useful data; one studied the correlation of HLA class 1 expression in adenomas and carcinomas (Chatzipetrou et al 1999), five studied genetic alterations and HLA class 1 expression (Kaklamanis et al 1992;Momburg et al 1989;Bar-Eli et al 1988;Shen et al 2005) and six did not have outcome data (Stein et al 1988; Van den Ingh et al 1987;Möller et al 1991a, b;Shen et al 2005;Goepel et al 1991). This left fourteen original studies to be included in this present review.…”

“…The determinants of the local immune response remain unclear; however, tumour antigen presentation via the HLA complex has been suggested. Loss of HLA class I expression has been implicated in tumour progression and metastasis; however, studies reporting its relationship with long-term survival are few in number with conflicting reports (Speetjens et al 2008;Watson et al 2006;Kloor et al 2005;Stam et al 1986Stam et al , 1990Perosa et al 2003;Seitz et al 1998;Sernee et al 1998;Chatzipetrou et al 1999;Kaklamanis et al 1992;Momburg et al 1989;Bar-Eli et al 1988;Stein et al 1988; Van den Ingh et al 1987;Möller et al 1991a, b).…”

“…Within the class 1 complex, there are six sub-groups of the HLA heavy chain titled HLA-A, HLA-B, HLA-C, HLA-E, HLA-F and HLA-G. The antibody HC10 preferentially binds to HLA-B and HLA-C (Sernee et al 1998;Chatzipetrou et al 1999;Kaklamanis et al 1992). The antibody HCA2 preferentially binds to HLA-A, HLA-B73, HLA-C as well as HLA-E, HLA-F, HLA-G (Stam et al 1986;Seitz et al 1998;Sernee et al 1998) with the EMR8-5 and W6/32 antibodies both preferentially binding to HLA-A, HLA-B, HLA-C (Brodsky et al 1979).…”

Studying HLA class I polymorphism in brain tumour patients

“…HLA association with diseases is a further important feature of HLA system, and since the first demonstration of a significant correlation between HLA-B27 and ankylosing spondylitis in 1973, the literatures are overwhelmed to reveal the significance of HLA molecules in conferring the individual an immunogenetic predisposition to develop diseases of different natures; autoimmune, infectious and malignant diseases. The mechanisms behind such association are subjected to different speculations [6].Concerning tumours, the association of HLA alleles with solid tumours, such as nasopharyngeal, colorectal, or thyroid carcinoma has been described, reviewed by [7]. HLA-B18 was significantly increased in patients with nasopharyngeal carcinoma [8], and in patients diagnosed with pancreatic cancer [9].…”