Human leukocyte antigen phenotypes and hepatitis C viral load

Wang, Li-Yu; Lin, Hans Hsienhong; Lee, Tsung-Dao; Wu, Ya-Fang; Hu, Chi-Tan; Cheng, Mu-Liang; Lo, Shih-Yen

doi:10.1016/j.jcv.2004.05.011

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…HLA-A*02, -A*11, -A*33, -B*40, -B*58, -Cw*01, -Cw*03, and -Cw*07 are the most frequent HLA alleles in the present study population. Among these HLA alleles, previous reports showed that the presence of HLA-B*40 was associated with higher circulating HCV viral load [Wang et al, 2005]; HLA-A*11, -Cw*01, and -Cw*03 associated with treatment success [Miyaguchi et al, 1997;Korenaga et al, 2001;Yu et al, 2003]. The present study revealed no statistical association with HLA allelic type and tested clinical character, probably due to the small sample size.…”

Section: Discussioncontrasting

confidence: 63%

“…HLA class I alleles have been demonstrated in association with certain clinical features including HCV persistence [Thio et al, 2002], disease progession [Kuzushita et al, 1998], viral load [Miyaguchi et al, 1997;Wang et al, 2005] and therapeutic outcomes in chronic hepatitis C patients [Miyaguchi et al, 1997;Kikuchi et al, 1998;Korenaga et al, 2001;Yu et al, 2003], although there is no or only marginal such HLA class I-disease association in other reports [Hohler et al, 1997;Minton et al, 1998;Vejbaesya et al, 2000;Tillmann et al, 2001;Patel et al, 2006]. HLA-A*02, -A*11, -A*33, -B*40, -B*58, -Cw*01, -Cw*03, and -Cw*07 are the most frequent HLA alleles in the present study population.…”

Section: Discussionmentioning

confidence: 99%

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Therapy with interferon‐α and ribavirin for chronic hepatitis C virus infection upregulates membrane HLA‐ABC, CD86, and CD28 on peripheral blood mononuclear cells

Cheng

Wei

Chang

et al. 2008

Journal of Medical Virology

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Multiple interferon-stimulated genes (ISGs) involving T-cell activation are upregulated during initial interferon-alpha-based therapy for chronic hepatitis C virus (HCV) infection. However, the long-term impact on therapeutic outcome in patients remains unknown. In this study, the effects of anti-HCV therapy on the surface expression of HLA-ABC, CD86, and CD28 were longitudinally assessed. These proteins are integral membrane receptors of antigen presentation and triggering of costimulatory signals for activating CD8+ T cells. Peripheral blood mononuclear cells were collected at baseline and post-treatment for 1 day, and 2, 4, 12, and 24 weeks, respectively. This treatment led to a time-related elevation of membrane levels of HLA-ABC and CD86 on B-cells and monocytes in patients with a sustained response (n = 23), but not in those without (n = 8). Meanwhile, upregulation of CD28 on CD4+ and CD8+ T cells was comparable in both groups of sustained responders and non-responders. Steady increases in the B cells' surface and intracellular HLA-ABC were observed, thus, the surface-to-intracellular ratios did not alter over the period of treatment. Furthermore, multivariate analysis shows that increased HLA-ABC on monocytes by week 12 correlates significantly with sustained response (P = 0.033). In conclusion, differential modulation of T-cell activation ISGs, such as HLA-ABC and CD86 might correlate with the outcome of interferon-alpha-based therapy in chronic hepatitis C patients.

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Section: Discussioncontrasting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Therapy with interferon‐α and ribavirin for chronic hepatitis C virus infection upregulates membrane HLA‐ABC, CD86, and CD28 on peripheral blood mononuclear cells

Cheng

Wei

Chang

et al. 2008

Journal of Medical Virology

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“…HLA Class I alleles were not associated with viral load, fibrosis stage, liver inflammation or treatment outcome in Irish and American studies [25,41]. However, in a Taiwanese study [42], patients with chronic HCV infection with HLA alleles (A*34, B*56) have significantly lower viral load than those without these alleles, while those with HLA-B*4001 have significantly higher viral load. In Japanese, an influence of HLA haplotypes on the clinical courses of individuals infected with chronic HCV was suggested based on an association between Class I B54 and the progression of liver injury [30].…”

Section: Discussionmentioning

confidence: 85%

Association of Human Leucocyte Antigen Class I (HLA-A and HLA-B) With Chronic Hepatitis C Virus Infection in Egyptian Patients

Mosaad

Farag

Arafa

et al. 2010

Scandinavian Journal of Immunology

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Egypt has the highest prevalence of hepatitis C virus (HCV) in the world, ranging from 6% to 28% with an average of approximately 13.8% in the general population. It has been reported that human leucocyte antigen (HLA) alleles are associated with the outcome of HCV infection, but this associations showed ethnic and geographical differences. The objective of this study is to investigate the association between the frequencies of HLA Class I and chronic HCV infection in Egyptian patients and to find out whether there is a relation between certain HLA Class I antigens and HCV viral load, degree of fibrosis, activity and alanine aminotransferase (ALT) level. A case control study was conducted on 100 patients with chronic HCV infection and 150 healthy controls. HLA‐A and HLA‐B typing by complement‐dependent micro‐lympho‐cytotoxicity assay was performed for both groups. HLA‐A11 antigen was significantly increased in patients with chronic HCV infection versus controls (OR 3.98; 95% CI = 1.85–8.89; P = 0.001; and Pc = 0.021). HLA‐B12, HLA‐B13, HLA‐B17 and HLA‐B40 were higher in patients, and HLA‐A32 and HLA‐B14 were higher in controls, although the significance was lost after correction for multiple testing. HLA‐A9 was significantly associated with low viral load (P = 0.008, Pc = 0.048). The results of this work implicate that HLA‐A11 antigen may influence chronic HCV infection and may play a role in viral persistence. Different HLA Class I antigens are not associated with degree of liver fibrosis, grades of activity or level of ALT. However, HLA‐A9 is associated with low HCV viral load in chronic HCV Egyptian patients.

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“…However, in the present study, only 2 patients had such a profile, and, therefore, only univariate associations between allele type and patient survival were possible. Correlations between HLA composition and disease susceptibility or severity have been identified for other viral infections, including those due to HIV [21][22][23][24][25], herpes viruses [26,27], hepatitis B and C viruses [28][29][30], dengue virus [31], hantaviruses [32,33], and severe acute respiratory syndrome coronavirus [34,35]. It has also been reported that HLA-B-restricted epitopes exhibit a greater functional avidity (T cell receptor avidity for HLA-peptide complex) than do HLA-Aor HLA-C-restricted epitopes [36], which suggests a significant role for HLA-B alleles in acquired antiviral immunity.…”

Section: Discussionmentioning

confidence: 99%

Sequence‐Based Human Leukocyte Antigen–B Typing of Patients Infected with Ebola Virus in Uganda in 2000: Identification of Alleles Associated with Fatal and Nonfatal Disease Outcomes

2007

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The Sudan species of Ebola virus (SEBOV) causes severe, often fatal infection in approximately 50% of infected humans. We sought to determine whether the human leukocyte antigen-B (HLA-B) locus has a role in the outcome of SEBOV disease by typing 77 cases from an outbreak in northern Uganda in 2000-2001. Sequence-based HLA-B typing was performed using leukocytes isolated from 77 patients. Statistical analysis and a predictive discriminant analysis (PDA) were applied to typing data. Epitope prediction software was also applied to SEBOV sequences. Statistically significant associations were found between certain sets of alleles and either fatal or nonfatal disease outcomes. Alleles B*67 and B*15 were associated with fatal outcomes, whereas B*07 and B*14 were associated with nonfatal outcomes. The PDA-derived functions that were produced were 81.8% accurate in classifying patients into their correct outcome group. Several epitopes predicted to bind strongly to HLA-B*07 molecules were identified in the viral polymerase, nucleoprotein, and VP35 protein. HLA-B alleles associated with either fatal or nonfatal outcomes of SEBOV disease were identified and can be used in a predictive model. Studies of HLA-B-restricted epitopes could contribute to characterization of protective host responses and to vaccine development.

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Human leukocyte antigen phenotypes and hepatitis C viral load

Cited by 12 publications

References 33 publications

Therapy with interferon‐α and ribavirin for chronic hepatitis C virus infection upregulates membrane HLA‐ABC, CD86, and CD28 on peripheral blood mononuclear cells

Therapy with interferon‐α and ribavirin for chronic hepatitis C virus infection upregulates membrane HLA‐ABC, CD86, and CD28 on peripheral blood mononuclear cells

Association of Human Leucocyte Antigen Class I (HLA-A and HLA-B) With Chronic Hepatitis C Virus Infection in Egyptian Patients

Sequence‐Based Human Leukocyte Antigen–B Typing of Patients Infected with Ebola Virus in Uganda in 2000: Identification of Alleles Associated with Fatal and Nonfatal Disease Outcomes

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