2017
DOI: 10.1111/tan.13102
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Human leukocyte antigen distribution and genomic ancestry in Brazilian patients with sickle cell disease

Abstract: Hematopoietic stem-cell transplantation (HSCT) is currently the only established curative treatment for sickle cell disease (SCD), but is limited by donor availability. Ethnicity is thought to have an impact on the complications experienced by patients that undergo HSCT and on the likelihood of identifying an human leukocyte antigen (HLA) matched donor. In the present study, we investigated the genomic ancestry and the distribution of HLA allele groups in Brazilian patients with SCD, compared these HLA profile… Show more

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Cited by 4 publications
(7 citation statements)
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References 56 publications
(95 reference statements)
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“…This result may point to alleles that can be associated to this condition. The same is observed in the population composed by sickle cell anemia patients, which may reflect a higher African genetic background in these individuals.…”
Section: Discussionsupporting
confidence: 74%
See 2 more Smart Citations
“…This result may point to alleles that can be associated to this condition. The same is observed in the population composed by sickle cell anemia patients, which may reflect a higher African genetic background in these individuals.…”
Section: Discussionsupporting
confidence: 74%
“…A study with patients with sickle cell anemia in the state of Minas Gerais investigated genomic ancestry based on HLA variability. When comparing the HLA frequencies of this population with European, African and Native American populations, the Brazilian population of patients with sickle cell anemia in this study indicated a significant African component, in spite of significant admixture …”
Section: Transplant and Disease Association Studiesmentioning
confidence: 74%
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“…Determinations could not be made in all cases. Another approach was to determine the ethnicity by using ancestry‐informative markers . This was not possible in all cases due to the fact that we analyzed empirical data with ambiguous typing resolution.…”
Section: Methodsmentioning
confidence: 99%
“…Another approach was to determine the ethnicity by using ancestry-informative markers. 10 This was not possible in all cases due to the fact that we analyzed empirical data with ambiguous typing resolution. In light of this and the small sample size compared with other publications, [11][12][13][14][15][16][17][18] these families were kept in the analysis.…”
Section: Properties Of the Samplementioning
confidence: 99%