Human leukocyte antigen compatibility and lymphocyte cross‐matching play no significant role in the current adult‐to‐adult living donor liver transplantation

Abstract

Positive LCM and HLA mismatches did not affect the overall graft survival after adult-to-adult LDLT and should not be considered as contraindications for liver transplantation.

Autoantibodies to LG3 are associated with poor long‐term survival after liver retransplantation

“…The detrimental roles of donor-specific antibodies (DSA) to human leukocyte antigen (HLA) are well-established in transplantation of kidney, pancreas, heart, lung, and intestine, 1-3 but less so in liver transplantation (LT). [4][5][6][7][8][9][10][11] Antibodies to non-HLA antigens, such as autoantibodies or natural polyclonal antibodies, were also described in recipients of solid organs 12 and allogeneic hematopoietic stem cells. 13 Autoantibodies, which may be generated through the exposure of cryptic antigens, are detrimental for the survival of the kidney, [14][15][16] lung, 17 heart, 18,19 liver, [20][21][22] and intestinal 23 allografts.…”

Vascularized composite allotransplantation in the United States: A retrospective analysis of the Organ Procurement and Transplantation Network data after 5 years of the Final Rule

“…Numerous studies explore the influence of HLA mismatch in living-donor SOT outcomes, with varying results reported in the liver literature, when examining analyses of OPTN vs international data. [25][26][27] One recent study of living-related-donor kidney transplants showed that close HLA matching between child donors and parent recipients afforded lower rates of graft failure and comparable mortality. 28 The OPTN VCA data do not report information on the HLA mismatch among living-donor uterus transplantation.…”

“…Important questions in translational immunology could be analyzed by this parameter, particularly in the setting of living‐donor VCAs. Numerous studies explore the influence of HLA mismatch in living‐donor SOT outcomes, with varying results reported in the liver literature, when examining analyses of OPTN vs international data 25–27 . One recent study of living‐related‐donor kidney transplants showed that close HLA matching between child donors and parent recipients afforded lower rates of graft failure and comparable mortality 28 .…”

Donor‐dominant one‐way matching of human leukocyte antigen‐A/B/DR alleles predicts graft‐versus‐host disease following living donor liver transplantation

“…5 There have been several reports that HLA matching has no impact on the occurrence of rejection after liver transplantation. 13,19 Nevertheless, accurate HLA typing at the allele level is essential for GVHD prevention because of donor-dominant one-way HLA matching.…”

“…We started a steroid-free regimen in February 2011. 13 Tacrolimus and mycophenolate mofetil were subsequently used as immunosuppressants. The target blood trough level for tacrolimus was maintained between 10 and 15 ng/mL during the first 2 weeks, 7-10 ng/mL during the third to fifth week, and 5-8 ng/mL thereafter.…”