Human leukocyte antigen class II allele association to disease progression in Iranian patients with chronic lymphocytic leukemia

Hojjat‐Farsangi, Mohammad; Jeddi-Tehrani, Mahmood; Amirzargar, Ali Akbar; Razavi, Seyed Mohsen; Sharifian, Ramazan Ali; Rabbani, Hodjatallah; Shokri, Fazel

doi:10.1016/j.humimm.2008.07.015

Cited by 14 publications

(22 citation statements)

References 41 publications

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“…Association of certain HLA class I [17] or HLA class II [14,18] alleles with the clinical course of the disease has also been reported in different malignancies.…”

Section: Introductionmentioning

confidence: 88%

“…Consent letter was taken from all patients and the study was approved by the Ethical Committee of Tehran University of Medical Sciences. CLL diagnosis and classification of our patients have been described previously [14].…”

Section: Patients and Controlsmentioning

confidence: 99%

“…Patients were considered to have progressive disease if the following criteria were met: progression during the preceding 3 months in disease-related anemia (hemoglobin <100 g/l), thrombocytopenia (<100 x 109/l) and/or an increase in spleen/liver/lymph node size and/or more than a 2-fold increase in the blood lymphocyte count [14,27,28]. HLA typing results were compared with those obtained from 64 Iranian healthy blood donors.…”

Section: Patients and Controlsmentioning

confidence: 99%

“…Expression of certain HLA class I or II alleles has been shown to be associated with a variety of infections and autoimmune or malignant disorders [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…In a prior study we reported the frequency of some HLA class I A, B and C antigens in a limited number of CLL patients using the serological microlymphocytotoxicity technique [4]. Later, we reported the HLA class II allele frequencies in a large number of Iranian CLL patients and their correlation to disease progression and IGHV mutation [14]. In the current study, we investigated the frequency of HLA-class I A and B alleles and haplotypes by SSP-PCR technique in the same set of patients.…”

Section: Introductionmentioning

confidence: 99%

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Frequency analysis of HLA class I alleles in Iranian patients with progressive and non-progressive chronic lymphocytic leukemia

et al. 2014

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Chronic lymphocytic leukemia (CLL) is a malignant disorder of B cell origin, with low incidence in Asian populations. In this study we investigated the HLA-class I A and B allele frequencies in 87 Iranian CLL patients and 64 healthy controls using sequence specific primer-polymerase chain reaction (SSP-PCR) technique. Our results showed increased frequencies of HLA-A11:01 (p=0.02) and HLA-B35:01 (p=0.002) alleles and HLA-A11:01/B35:01 haplotype (p=0.036) and decreased frequencies of HLA-A01:01 (p=0.02), HLA-A26:01 (p=0.03), HLA-B65:01 (p=0.03) and HLA-B53:01 (p<0.00001) alleles in CLL patients compared to the control group.Classification of the patients into non-progressive and progressive groups did not reveal significant differences for the frequency of any of the HLA-A and B alleles or haplotypes between these two subtypes. Comparison between patients with immunoglobulin heavy chain variable region genes (IGHV) mutated (n=56) and unmutated (n=31) subtypes showed a significant increase in HLA-A32:01 (p=0.05) and HLA-A33:01 (p=0.05) alleles in IGHV unmutated patients compared to IGHV mutated patients. Similarly, a higher frequency of HLA-B52:01 (p=0.037) alleles was observed in CD38+ compared with CD38-patients. Our results obtained from an Iranian population indicate that CLL is associated with distinct HLA class I alleles and haplotypes some of which are linked to disease prognostic factors.3

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“…Association of certain HLA class I [17] or HLA class II [14,18] alleles with the clinical course of the disease has also been reported in different malignancies.…”

Section: Introductionmentioning

confidence: 88%

Section: Patients and Controlsmentioning

confidence: 99%

Section: Patients and Controlsmentioning

confidence: 99%

“…Expression of certain HLA class I or II alleles has been shown to be associated with a variety of infections and autoimmune or malignant disorders [14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations