Human Leukocyte Antigen and Cytokine Receptor Gene Polymorphisms Associated With Heterogeneous Immune Responses to Mumps Viral Vaccine

Abstract

These data suggest the important role of HLA and immunoregulatory cytokine receptor gene polymorphisms in explaining variations in mumps vaccine-induced immune responses.

Seroepidemiology of the recent mumps virus outbreaks in Ireland

“…21 Furthermore, a recent study examining HLA and cytokine receptor gene polymorphisms showed that a significantly higher mumps antibody titre was demonstrated in females compared to males which indicates gender-linked genetic differences in the development of humoral immune responses. 22 Reports also indicate a gender influence on the development of humoral responses to live measles 23 and rubella vaccines. 24 HLA supertypes and alleles of the DRB1, DQA1 and DQB1 loci were associated with significant variations in humoral and cellular immune responses to mumps vaccine in vitro.…”

Vaccinomics and a New Paradigm for the Development of Preventive Vaccines Against Viral Infections

“…From the clinical deliverable (product) point of view, our work, as briefly reviewed above, has illustrated significant associations between genetic polymorphisms and immune response heterogeneity to live viral vaccines (Dhiman et al, 2007Poland et all, 2001;Ovsyannikova et al, 2004aOvsyannikova et al, , 2005aOvsyannikova et al, , 2008Sauver et al, 2002). Population-based immunogenetic studies inform and elucidate the mechanisms of protective immunity and provide a foundation for future vaccine development.…”

Vaccinomics: Current Findings, Challenges and Novel Approaches for Vaccine Development

“…In a cohort of 346 healthy children, DQB1*0201 (p=0.04), DQB1*0402 (p=0.02), DQA1*0401 (p=0.003), DRB1*0301 (p=0.02), DRB1*0801 (p=0.02), DRB1*1201 (p=0.04), and DRB1*1302 (p=0.01) alleles were significantly associated with low lymphoproliferative responses to mumps vaccine (18). Interestingly, subjects who carried the DRB1*03-DQB1*02-DPB1*04 haplotype had high lymphoproliferative responses to both measles (p=0.01) and mumps viruses (p=0.006) (15).…”

“…Importantly, we demonstrated that B*2705 alleles are associated with low rubella-induced antibody levels in two independent cohorts of subjects (16). In regard to cellular immunity, B*3503 (p= 0.031) and C*1502 (p=0.035) alleles are associated with high levels of lymphocyte proliferation to rubella virus, and B*1302 (p=0.02), B*3701 (p=0.01), and B*3801 (p=0.007) alleles are associated with high levels of lymphoproliferation to mumps virus following two doses of MMR vaccine (17,18). Important associations of class I alleles with cytokine responses to rubella vaccine were also discovered.…”