Human Leukocyte Antigen Alleles and Haplotypes Associated with Selective Immunoglobulin A Deficiency in Spanish Pediatric Patients

Clerici, N.; Fernández, Miguel; Saiz, Isabel; Sainz, Teofilo; Polanco, Isabel

doi:10.1097/00005176-199305000-00006

Cited by 11 publications

(7 citation statements)

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“…The studied probands represent a typical Caucasian population of mixed North and South European origin. Therefore, these data con®rm the previously reported association of IgA de®ciency with the HLA haplotype (B*08:)DRB1*0301:DQB1*0201 among Caucasians from Northern Europe and North America [4,6,17], and with the HLA haplotype (B*14:)DRB1*0102:DQB1*0501 in IgA-de®cient probands from Southern Europe [2,18]. In addition, the increased frequency of the HLA haplotype B*44:DRB1*0701: DQB1*0202 in this study corresponds with results from studies in North America [6].…”

Section: Discussionsupporting

confidence: 90%

HLA‐A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 Frequencies in German Immunoglobulin A‐Deficient Individuals

et al. 2000

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HLA class I and II frequencies and haplotype frequencies were determined in 80 German immunoglobulin (Ig)A‐deficient individuals and 157 healthy controls with normal IgA levels using serological and DNA typing methods. For several alleles, significant associations were found, which could be explained mainly in the context of a positive association with three different extended haplotypes (HLA‐B*08:DRB1*0301: DQB1*0201, HLA‐B*14:DRB1*0102:DQB1*0501 and HLA‐B*44:DRB1*0701:DQB1*0202) and a negative association with a fourth haplotype (HLA‐B*07:DRB1*1501:DQB1*0602). Furthermore, for the first time this study reports a positive association of IgA deficiency with DPB1 alleles. Homozygosity rate for the gene loci DRB1 and DQB1 was increased in IgA deficiency. Further analysis suggested a different pattern of HLA associations depending on the degree of IgA deficiency and the gender of the IgA‐deficient individuals.

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Section: Discussionsupporting

confidence: 90%

HLA‐A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 Frequencies in German Immunoglobulin A‐Deficient Individuals

et al. 2000

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“…The exact nature of the relationship between these two conditions remains elusive. However, human leukocyte antigen alleles and haplotypes such as HLAB8, DR3, DR7, and DQ2 have been shown to occur more frequently in both conditions, suggesting a possible link with human leukocyte antigens (33,34). On the other hand, the absence of mucosal IgA in patients with sIgAD disrupts mucosal clearance of food antigens, and the passage of some molecules into subepidermal and submucosal tissue may facilitate the production of antibodies against these antigens in individuals with a genetic susceptibility for developing celiac disease.…”

Section: Discussionmentioning

confidence: 99%

Allergic and autoimmune disorders in families with selective IgA deficiency

et al. 2017

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Background/aim: IgA deficiency is the most common human primary immunodeficiency. The prevalence of allergic disorders and autoimmunity is thought to be increased in selective IgA deficiency (sIgAD). However, it is currently unclear if these disorders coincide within these families. We aimed to evaluate the frequency of allergic and autoimmune disorders in children with sIgAD and their firstdegree relatives (FDRs). Materials and methods:The study included 81 children diagnosed with sIgAD and 274 of their FDRs. The presence of allergic and autoimmune disorders was evaluated and serum antithyroglobulin and antithyroid peroxidase levels were measured in both patients and their first-degree relatives. Results:The mean age of the patients was 9.9 ± 3.9 years. Among the patients with sIgAD, 45.7% of them had at least one allergic disorder and 17.3% of them had at least one autoimmune disorder. The frequencies of asthma, allergic rhinitis, and eczema in the FDRs of sIgAD patients were 10.9%, 9.1%, and 7.7%, respectively. Among their FDRs, 14.6% had autoimmunity, compared to an estimate of 5% in the general population. Conclusion:Increased frequency of allergic and autoimmune disorders in patients with sIgAD and their FDRs suggests a possible common predisposing genetic component for sIgAD and autoimmunity in these families.

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“…An association with B8 or with DR3, but not with B14 or DR1, has been observed in IgA-D subjects from Hungary (Ambrus et al, 1977), Canada (Oen et al, (Jersild et al, 1983) and Sweden (Hammarström & Smith, 1983;Hammarström et al, 1984), whereas association with B14 or DR1, but not with B8 or DR3, was described in Italians (Cuccia-Belvedere et al, 1989;Fiore et al, 1995). In a study conducted in Spain, both haplotypes were associated with IgA-D (Clerici et al, 1993). The association of IgA-D with B8, DR3, characteristically observed in Northern European populations, and the association with B14, DR1, found in conjunction with the association with B8, DR3, or as the only association, in Southern European populations, probably reflects the frequency of these haplotypes in these two groups of European populations (Imanishi et al, 1992).…”

Section: Discussionmentioning

confidence: 95%

HLA antigens and haplotypes in IgA‐deficient Brazilian paediatric patients

Gerbase‐DeLima

Pinto

Grumach

et al. 1998

European Journal of Immunogenetics

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In the present study we determined the HLA-A, B and DR antigenic and haplotypic frequencies in unrelated Brazilian Caucasian paediatric patients with IgA deficiency (IgA-D). Out of 17 IgA-D subjects typed for HLA A and B specificities, 12 (71%) presented B8 and/or B14; of 15 patients also typed for HLA-DR specificities, 14 (93%) were positive for at least one of the HLA markers previously reported to be associated with IgA-D, i.e. B8, B14, DR1, DR3 or DR7. The haplotypes B8, DR3, B14, DR1 and B13, DR7 were present in 43, 21 and 14% of the cases, respectively, while they have a frequency in the general population of 2, 2 and 1%, respectively. The concomitant association with the three IgA-associated haplotypes found in our study probably reflects the admixture of European genetic influences present in the Brazilian Caucasian population of São Paulo.

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Human Leukocyte Antigen Alleles and Haplotypes Associated with Selective Immunoglobulin A Deficiency in Spanish Pediatric Patients

Cited by 11 publications

References 0 publications

HLA‐A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 Frequencies in German Immunoglobulin A‐Deficient Individuals

HLA‐A, B, Cw and DRB1, DRB3/4/5, DQB1, DPB1 Frequencies in German Immunoglobulin A‐Deficient Individuals

Allergic and autoimmune disorders in families with selective IgA deficiency

HLA antigens and haplotypes in IgA‐deficient Brazilian paediatric patients

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