“…An association with B8 or with DR3, but not with B14 or DR1, has been observed in IgA-D subjects from Hungary (Ambrus et al, 1977), Canada (Oen et al, (Jersild et al, 1983) and Sweden (Hammarström & Smith, 1983;Hammarström et al, 1984), whereas association with B14 or DR1, but not with B8 or DR3, was described in Italians (Cuccia-Belvedere et al, 1989;Fiore et al, 1995). In a study conducted in Spain, both haplotypes were associated with IgA-D (Clerici et al, 1993). The association of IgA-D with B8, DR3, characteristically observed in Northern European populations, and the association with B14, DR1, found in conjunction with the association with B8, DR3, or as the only association, in Southern European populations, probably reflects the frequency of these haplotypes in these two groups of European populations (Imanishi et al, 1992).…”