Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry

Tshabalala, Mqondisi; Ingram, Charlotte; Schlaphoff, Terry; Borrill, Veronica; Christoffels, Alan; Pepper, Michael Sean

doi:10.1155/2018/2031571

Cited by 9 publications

(21 citation statements)

References 62 publications

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“…The common HLA types identified in this study population were compared with common HLA types found in populations of different nationalities (Table 2). [31][32][33][34][35] Common HLA frequencies at the A allele in our study corresponded to those found in a British, French, Chinese, and African American population. [31][32][33][34][35] B and DRB1 loci, common in British and French populations, were also well represented in our population.…”

Section: Resultssupporting

confidence: 88%

A Retrospective Study on Human Leukocyte Antigen Types and Haplotypes in a South African Population

Gandini

Mampeule

Jugwanth

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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Context.— Human Leukocyte Antigen (HLA) is a polymorphic protein of the immune system with a central role in organ transplantation. Organ recipients can be sensitized against HLA from previous exposure, which increases the likelihood of antidonor immune responses and subsequently organ rejection. HLA matching represents an attractive option to improve graft function, reduce sensitization of recipients in first transplantations, and improve organ allocation. Objective.— To examine the feasibility of the reintroduction of HLA matching into the criteria in the Johannesburg program, we retrospectively assessed HLA types in our donor population. Design.— HLA types of 782 deceased and related living donors from 2015 until 2019 were recorded and analyzed to identify the most common HLA types and haplotypes. A virtual crossmatch was also done to examine the anti-HLA antibodies in the recipient population compared with the common HLA types identified in this study. Results.— Of the commonest HLA types identified, at least 1 was present in 732 (93.6%) of the renal donors assessed. The virtual crossmatch confirmed that most recipients are sensitized against most donors, and this greatly impacts the number of recipients who can receive organ transplants. Conclusions.— This study determined the most common HLA types and haplotypes in a South African organ donor population. This information, combined with the evidence suggesting the immunogenic potential of these common types, the high number of recipients with antibodies against common HLA types, and the ethnic distribution of the donor and recipient populations, informs the recommendation that the pretransplantation workup should not reinclude HLA matching.

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Section: Resultssupporting

confidence: 88%

A Retrospective Study on Human Leukocyte Antigen Types and Haplotypes in a South African Population

Gandini

Mampeule

Jugwanth

et al. 2020

Archives of Pathology &Amp; Laboratory Medicine

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“…All HLA allele group subsets deviated from the expected HWE (p < 0.05), even within the different reported ethnic groups. This finding was expected based on our population's diverse heterogenous genetic makeup and is comparable to results reported from similarly diverse populations [ 13 , 21 ]. We determined the three most common allele groups for each subtype for the total population, the various ethnic groups, and the donor populations ( Table 2 ).…”

Section: Resultssupporting

confidence: 92%

“…Therefore, targeted HLA sequencing of the diverse southern African populations is essential to increase their representation in global reference panels [ 12 ]. According to a 2018 South African Bone Marrow Registry (SABMR) study, determining HLA alleles and haplotypes will contribute to the development of a resource for disease association, anthropology, and evolutionary studies, support models for population-specific vaccine development and advance donor enrolment in South African populations [ 13 ]. The last formal study on people residing in our local Free State Province, South Africa, was published in 1997 [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Taking human migration and a steady increase in urbanisation in South Africa into consideration [ 15 ], it can be hypothesised that a possible change in HLA-allele frequencies may have occurred since the previous publication. Furthermore, the majority of the South African HLA studies focus mainly on healthy individuals [ 13 , 14 , 16 , 17 ]. Therefore, determining HLA-frequencies in specific disorders may significantly contribute to establishing disease-specific reference panels for our population.…”

Section: Introductionmentioning

confidence: 99%

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HLA major allele group frequencies in a diverse population of the Free State Province, South Africa

Rensburg

Kock

Bester

et al. 2021

Heliyon

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Background: Human Leucocyte Antigens (HLA) play a vital role in disease pathogenesis and transplant rejection. HLA-typing is a useful tool in predicting disease progression and to identify potential organ donors. Due to human migration and known ethnic variation, frequent targeted HLA sequencing of specific populations is crucial to increase their representation in global reference panels. Materials and methods: We performed a retrospective file audit of all HLA-typings done in our setting from 2005-2019. We discuss data for the major HLA-A, HLA-B, HLA-C, and HLA-DRB1 allele groups. Results: Overall, the most common allele groups were HLA-A*02, HLA-B*15, HLA-C*07 and HLA-DRB1*03. For the African descent group, the most common alleles were HLA-A*30, HLA-B*15, HLA-C*07 and HLA-DRB1*03. For the European descent group, the most common alleles were HLA-A*02, HLA-B*07, HLA-C*07 and HLA-DRB1*15. For the mixed ancestry group, the most common allele groups were HLA-A*02, HLA-B*15, HLA-C*02 and HLA-DRB1*13. HLA-B*44 was identified as the most common allele group in patients with renal failure. Discussion and conclusion: The significant variation within the HLA frequencies between the different ethnic groups highlights the value of population-specific HLA-typing. Furthermore, the identification of HLA-B*44 as a prominent HLA in our renal failure population warrants in-depth investigation of this group.

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“…The most frequent alleles were HLA-A∗23:01 (31.4%), HLA-C∗07:01 (29.3%) and HLA-C∗04:01 (28.6%). These common HLA types have been previously described in other populations in sub Saharan Africa (SSA), and in Cameroon, HLA-A∗23:01, HLA-C∗04:01 and HLA-C∗07, have been reported to be very common ( Ellis et al., 2000 ; Shepherd et al., 2015 ; Spinola et al., 2008 ; Torimiro et al., 2006 ; Tshabalala et al., 2018 ; Yindom et al., 2010 ). In the present study, the number of individuals carrying either HLA-A∗30:01 or HLA-C∗17:01 was significantly higher in the groups infected with either HBV or HCV, respectively, suggesting that these alleles may predispose their carriers to acquiring these hepatitis viruses.…”

Section: Discussionsupporting

confidence: 54%

Variation of HLA class I (-A and -C) genes in individuals infected with hepatitis B or hepatitis C virus in Cameroon

Yengo

Torimiro

Kowo

et al. 2020

Heliyon

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The Human Leucocyte Antigens (HLA) work in concert with other immune factors to modulate immunity to viral infections. Extensive variation has been reported in the genetic sequences and functions of classical HLA class I genes in many (mostly Western) populations, and several HLA associations with infectious disease outcomes have been reported. Little is known about their role in the susceptibility or resistance to hepatitis viruses in Central African populations. The aim of this study was to determine variants of two HLA class I genes (HLA-A and -C) in adults infected with hepatitis B (HBV)- or -C (HCV) virus in Cameroon. In this case-control study, a total of 169 unrelated adults comprising 68 HCV-infected, 38 HBV-infected and 63 uninfected (controls) individuals participated. Each consented participant was screened for HBV, HCV, and HIV infections and willingly donated a single blood sample for genomic DNA isolation and some clinical laboratory tests. HLA-A and HLA-C were genotyped using previously described sequence-based techniques (SBT). A total of 54 HLA alleles were identified in the study population (27 HLA-A and 27 HLA-C). HLA-A∗23:01 and HLA-C∗07:01 were the most common alleles with genotype frequencies of 31.4% and 29.3%, respectively. Hepatitis individuals were six times more likely to be HLA-A∗30:01 carriers than uninfected controls (OR = 6.30, p = 0.020 (HBV); OR = 6.21, p = 0.010 (HCV), respectively). Similarly, carriers of HLA-C∗17:01 were over-represented in the HBV-infected compared to the uninfected control group (21.9% vs. 6.4%, respectively) suggesting that this allele could play a role in the susceptibility to HBV infection. These findings demonstrate that carriers of HLA-A∗30:01 were over-represented in the hepatitis group compared to uninfected controls while HLA-C∗17:01 was completely absent in the HCV + group.

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Human Leukocyte Antigen-A, B, C, DRB1, and DQB1 Allele and Haplotype Frequencies in a Subset of 237 Donors in the South African Bone Marrow Registry

Cited by 9 publications

References 62 publications

A Retrospective Study on Human Leukocyte Antigen Types and Haplotypes in a South African Population

A Retrospective Study on Human Leukocyte Antigen Types and Haplotypes in a South African Population

HLA major allele group frequencies in a diverse population of the Free State Province, South Africa

Variation of HLA class I (-A and -C) genes in individuals infected with hepatitis B or hepatitis C virus in Cameroon

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