Human Leptin Stimulates Proliferation and Activation of Human Circulating Monocytes

Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

“…Leptin, the product of the ob gene secreted by adipocytes, has been known to play a key role in the regulation of body weight, reproduction, hematopoiesis, and proinflammatory response (Bennett et al, 1996;Gainsford et al, 1996;Conway and Jacobs, 1997;Loffreda et al, 1998;Santos-Alvarez et al, 1999). Leptin acting as a functional link between adipocytes and the vasculature, might also play an important extrahypothalamic role in the modulation of adipose tissue mass.…”

Leptin and mTOR: Partners in metabolism and inflammation

“…11 In macrophages, leptin acts as a potent chemoatractant and induces the production of inflammatory mediators including LTB 4 , TNFα and IL-6 among others. [12][13][14] Lymphocytes are also activated by leptin, which stimulates the proliferation of Th1 cells, leading to increased production of IL-1 and IFNγ. Such activation may play a role on the development of autoimmune diseases.…”

Involvement of leptin signaling in the survival and maturation of bone marrow‐derived dendritic cells

“…Several studies have revealed an important role for leptin in regulating lymphopoiesis and hematopoiesis [1,2,[6][7][8]. For example, leptin has been shown to stimulate proliferation and increase the production of a variety of cytokines in rodent T cells and monocytes/macrophages [2,[9][10][11]. In relation to the important function of leptin in immune responses, leptin receptor (Ob-R) expression has been found not only in the central nervous system but also in peripheral lymphoid tissues and hematopoietic stem cells [2,8,12].…”