HUMAN LACTOFERRIN INCREASES THE EXPRESSION OF TRANSCRIPTION FACTOR c-FOS IN MOUSE BRAIN CELL CULTURE UNDER STIMULATED CONDITIONS

Kopaeva, Marina Yu.; Азиева, А. М.; Cherepov, Anton; Nesterenko, Mikhail; Zarayskaya, Irina Yu.

doi:10.29003/m2172.sudak.ns2021-17/200

Cited by 2 publications

(2 citation statements)

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“…Of great interest is the ability of Lf to modulate a whole range of processes by changing the expression of genes encoding some regulatory and effector proteins [ 69 , 70 ]. In our previous studies, we found that in neuronal cultures under conditions of stimulation, Lf enhances the expression of transcription factor c-Fos, a marker of neuronal activity and long-term plasticity [ 71 ]. Lf binding to the surface of immune cells suggests that it can trigger cell reactions such as differentiation, activation, and proliferation [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

New Properties of a Well-Known Antioxidant: Pleiotropic Effects of Human Lactoferrin in Mice Exposed to Gamma Irradiation in a Sublethal Dose

Kopaeva

Алчинова²,

Cherepov³

et al. 2022

Antioxidants

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We studied the effects of human lactoferrin (hLf), a multifunctional protein from the transferrin family, on integral (survival, lifespan during the experiment, body weight, behavior, subfractional compositions of blood serum) and systemic (hemoglobin level, leukocyte number, differential leukocyte count, histological structure of the liver and spleen) parameters of the body in mice after acute gamma irradiation in a sublethal dose. The experiments were performed on male C57BL/6 mice. The mice in the experimental groups were exposed to whole-body gamma radiation in a dose of 7.5 Gy from a 60Co source. Immediately after irradiation and 24 h after it, some animals received an intraperitoneal injection of hLf (4 mg/mouse). Single or repeated administration of hLf had a positive pleiotropic effect on irradiated animals: animal survival increased from 28% to 78%, and the mean life expectancy during the experiment (30 days) increased from 16 to 26 days. A compensatory effect of hLf on radiation-induced body weight loss, changes in homeostasis parameters, and a protective effect on the structural organization of the spleen were demonstrated. These data indicate that Lf has potential as a means of early therapy after radiation exposure.

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Section: Discussionmentioning

confidence: 99%

New Properties of a Well-Known Antioxidant: Pleiotropic Effects of Human Lactoferrin in Mice Exposed to Gamma Irradiation in a Sublethal Dose

Kopaeva

Алчинова²,

Cherepov³

et al. 2022

Antioxidants

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“…В наших предыдущих исследованиях было показано, что в нейрональных культурах в условиях стимуляции Лф усиливает экспрессию транскрипционного фактора c-Fos, являющегося маркером нейрональной активности и долговременной пластичности [22]…”

Section: результаты и обсуждениеunclassified

Effects of human lactoferrin under conditions of neurotoxic exposure: experimental research

Kopaeva

Cherepov

Zarayskaya

2022

Russian Military Medical Academy Reports

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BACKGROUND: Translational research using laboratory animals aimed at revealing the features of the pathogenesis of Parkinsons disease serve as a tool for finding new therapeutic strategies. AIM: Was to investigate the effects of human lactoferrin (a multifunctional globular glycoprotein) on behavior the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice as the model of dopaminergic neurons loss. MATERIALS AND METHODS: Nigrostriatal dopaminergic injury was induced by single administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (40 mg/kg) to five-month-old C57Bl/6 mice. Behavioral functions were assessed in the open field and rotarod tests and by the stride length analysis. RESULTS: Preliminary administration of lactoferrin resulted in a significant reduction in the severity of nervous system lesions induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. The positive effect of lactoferrin on the exploratory behavior of animals disturbed by neurotoxin, depending on the time of administration, was revealed. Exogenous protein with double preliminary administration had a protective effect on the change in body weight of mice after acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. This suggests a reduction in systemic toxic effects against the background of lactoferrin therapy. CONCLUSION: The results obtained indicate the possibility of the potential use of lactoferrin as a promising therapeutic agent in the treatment of neurodegenerative diseases.

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HUMAN LACTOFERRIN INCREASES THE EXPRESSION OF TRANSCRIPTION FACTOR c-FOS IN MOUSE BRAIN CELL CULTURE UNDER STIMULATED CONDITIONS

Cited by 2 publications

References 0 publications

New Properties of a Well-Known Antioxidant: Pleiotropic Effects of Human Lactoferrin in Mice Exposed to Gamma Irradiation in a Sublethal Dose

New Properties of a Well-Known Antioxidant: Pleiotropic Effects of Human Lactoferrin in Mice Exposed to Gamma Irradiation in a Sublethal Dose

Effects of human lactoferrin under conditions of neurotoxic exposure: experimental research

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