Human KIR sequences 2003

Abstract

We have compiled the nucleotide sequences and their amino acid translations from a total of 89 Killer Immunoglobulin-like Receptor (KIR) alleles, derived from 17 different KIR genes. The alignments use the KIR3DL2*001 allele as a reference sequence. Each of the KIR sequences included in these alignments has been checked and where discrepancies have arisen between reported sequences, the original authors have been contacted where possible, and necessary amendments to published sequences have been incorporated into this alignment. Future sequencing may identify errors in this list and we would welcome any evidence that helps to maintain the accuracy of this compilation.

Killer immunoglobulin-like receptors and HLA act both independently and synergistically to modify HIV disease progression

“…33 A limitation of this study is that the method used to type the KIR genes detects the presence or absence of a gene, but does not define recently described alleles. 34 Hence, improved discrimination of allelic variants may better define the haplotypes within the KIR complex, as has been shown in the MHC, and may allow the identification of even stronger associations between disease phenotypes and KIR genotype.…”

Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes

“…As positive controls, we used amplicons produced with the PCR primers Fg1160 and Rcon1238 (gacacctcctgatggtct) from the homologous regions of KIR2DS1 and KIR2DS4, genes which share with KIR2DS3*004 the PstI-cleavage site in exon 8. 33 Statistical significance of LD was estimated using the w 2 -test.…”

Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals

“…41 The number and type of KIR genes vary substantially between haplotypes 41,42 and display sequence polymorphism. 43,44 Patterns of linkage disequilibrium divide the KIR haplotype between 3DP1 and 2DL4 into two halves. 44,45 For genes within each half there is significant linkage disequilibrium, but it is much less for genes in the two different halves.…”