Human iPSC-derived neurons reveal NMDAR-independent dysfunction following HIV-associated insults
Alexander Starr,
Emily Nickoloff-Bybel,
Razan Abedalthaqafi
et al.
Abstract:The central nervous system encounters a number of challenges following HIV infection, leading to increased risk for a collection of neurocognitive symptoms clinically classified as HIV-associated neurocognitive disorders (HAND). Studies attempting to identify causal mechanisms and potential therapeutic interventions have historically relied on primary rodent neurons, but a number of recent reports take advantage of iPSC-derived neurons in order to study these mechanisms in a readily reproducible, human model. … Show more
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