Human iPSC-derived liver co-culture spheroids to model liver fibrosis
Laura Cools,
Mina Kazemzadeh Dastjerd,
Ayla Smout
et al.
Abstract:The lack of adequate human in vitro models that recapitulate the cellular composition and response of the human liver to injury hampers the development of anti-fibrotic drugs. The goal of this study was to develop a human spheroid culture model to study liver fibrosis by using induced pluripotent stem cell (iPSC)-derived liver cells. iPSCs were independently differentiated towards hepatoblasts (iHepatoblasts), hepatic stellate cells (iHSCs), endothelial cells (iECs) and macrophages (iMΦ), before assembly into … Show more
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