1967
DOI: 10.1001/archopht.1967.00980020695026
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Human Intraocular Penetration of Sodium Oxacillin

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Cited by 12 publications
(4 citation statements)
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“…In two studies conducted in 1966 and 1967, the vitreal concentration of semi-synthetic penicillin derivatives oxacillin and methicillin were studied following systemic administration. In both cases, vitreal concentrations were below known therapeutic concentrations [6,7]. A rabbit study evaluated the total concentration of penicillin in ocular tissues and found extremely high levels of penicillin in all ocular tissues except the lens and vitreous [8].…”
Section: Discussionmentioning
confidence: 99%
“…In two studies conducted in 1966 and 1967, the vitreal concentration of semi-synthetic penicillin derivatives oxacillin and methicillin were studied following systemic administration. In both cases, vitreal concentrations were below known therapeutic concentrations [6,7]. A rabbit study evaluated the total concentration of penicillin in ocular tissues and found extremely high levels of penicillin in all ocular tissues except the lens and vitreous [8].…”
Section: Discussionmentioning
confidence: 99%
“…Penicillin penetration into the aqueous and vitreous humours is generally poor84 85 even in the inflamed eye 86. Intraocular levels can be improved by concomitant use of probenecid, a tubule blocking drug87; that is, however, rarely used in practice.…”
Section: Treatmentmentioning
confidence: 99%
“…After oral administration, detectable levels are present in the milk of nursing mothers; substantial levels are found in bile (PRIGOTet al 1962). Oxacillin will penetrate into osseous and synovial tissues ofthe hip (FITZGERALD et al 1978), but will not cross the blood-aqueous barrier in the eye (RECORDS 1967). Lung tissue levels are approximately one-quarter of those in serum (KISS et al 1974).…”
Section: CImentioning
confidence: 99%