Human intraepithelial lymphocytes

Mowat, A M

doi:10.1007/bf00197504

Cited by 30 publications

(3 citation statements)

References 83 publications

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“…Many authors have suggested that IELs are important in the first line of the host defense (Ernst et al 1985;Mowat 1990). Antigen exposure in the oviduct frequently causes salpingitis, which is accompanied by reduced egg production or poor eggshell quality in mature chickens (Sevoian and Levine 1957;Crinion et al1971a, b), and hypoplasia of the epithelium in immature chicks (Crinion et al 1971a, b).…”

Section: Introductionmentioning

confidence: 98%

Development of T-lymphocyte subpopulations in the postnatal chicken oviduct

Khan

Hashimoto

Konno

et al. 1996

Cell and Tissue Research

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Postnatal development of t-cell subpopulations in the oviduct was investigated in the Dekalb strain of the White Leghorn chicken by using an immunohistochemical method. T-lymphocytes first infiltrated the oviduct at 5 weeks. The number of T cells peaked at 15 weeks in the magnum, isthmus and uterus, and at 19 weeks in the infundibulum and vagina. The epithelium of the oviduct contained both granular and agranular lymphocytes. TcR1+ cells were predominant in the epithelium, whereas TcR2+ cells were more numerous than TcR1+ cells in the lamina propria. TcR3+ cells were absent from the epithelium and were not numerous in the lamina propria. CT8+ cells, equivalent to CD8+ cells in mammals, were located both in the epithelium and in the lamina propria. The relative frequency of T-cell subpopulations was found to be higher in the vaginal part than in the other parts of the oviduct. These results suggest that the postnatal developmental changes of T-cell subpopulations depend on different anatomical regions of the oviduct and on the age of the chicken.

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Section: Introductionmentioning

confidence: 98%

Development of T-lymphocyte subpopulations in the postnatal chicken oviduct

Khan

Hashimoto

Konno

et al. 1996

Cell and Tissue Research

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“…The finding that a delayedtype hypersensitivity reaction could be inhibited when antigen-pulsed LP cells were adoptively transferred to syngeneic animals prior to antigenic challenge indicates that LP cells have a role in oral tolerance (43). Intraepithelial lymphocytes primarily express CD8 + and either R/β or γ/δ T-cell receptor repertoires (44). Of particular interest are recent studies that indicate that γ/δ T-cell receptor knock-out mice are unable to respond to traditional oral tolerance induction protocols (45), indicating that IELs can have an important role in the development of oral tolerance.…”

Section: Discussionmentioning

confidence: 99%

Immunochemical Detection and Identification of Protein Adducts of Diclofenac in the Small Intestine of Rats: Possible Role in Allergic Reactions

Ware

Graf

Martin

et al. 1998

Chem. Res. Toxicol.

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Idiosyncratic adverse drug reactions are unpredictable, target multiple organ systems, and often become life-threatening events. Although the causes of idiosyncratic adverse drug reactions are not known in most cases, evidence suggests that they may be mediated through immunological mechanisms. It is generally thought that for a drug to lead to an immune response, it must first become covalently bound to a carrier protein. Since most drugs are unreactive, it is usually a reactive metabolite that is expected to form covalent adducts. However, it is not clear why more people do not develop immune reactions against drug-protein adducts. One possible explanation is that orally administered drugs may lead to oral tolerance in most individuals through mechanisms similar to that found with orally administered antigens. However, very little is known regarding the interaction of drugs with gut-associated lymphoid tissue of the small intestine, where oral tolerance can develop. As an initial step to test this hypothesis, we have investigated whether diclofenac, a commonly used nonsteroidal antiinflammatory drug, can lead to protein adducts in rat small intestine. Diclofenac was administered to rats by gastric gavage. Immunoblot analysis of small intestine homogenates and isolated enterocyte subcellular fractions with drug-specific antiserum revealed 142-, 130-, 110-, and 55-kDa protein adducts of diclofenac. The 142- and 130-kDa adducts of diclofenac were identified as aminopeptidase N (CD13) and sucrase-isomaltase, respectively, by amino acid sequence analyses and by their reactions with protein-specific antibodies. The adducts were localized by immunohistochemistry and found primarily in the mid-villus and villus-tip enterocytes and also in the dome overlying Peyer's patches. Similar adducts were detected immunochemically in villus-tip enterocytes of animals treated with halothane or acetaminophen. These results show that intestinal protein adducts of drugs can be formed in gut-associated lymphoid tissue where they may lead to the down-regulation of drug-induced allergic reactions in many individuals.

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“…IEL are predominantly CD8+ (cytotoxic/suppressor) cells [1][2][3][4][5]. Over the last few years there has been considerable debate regarding the function of IEL [6,7]. Murine IEL have been shown to possess both cytotoxic and suppressive properties [8].…”

Section: Introductionmentioning

confidence: 99%

Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens

Dalton

DiPaolo

Sachdev

et al. 1993

Clinical and Experimental Immunology

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Human colonic intraepithelial lymphocytes from control subjects down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens or phytohaemagglutinin (PHA). In contrast, human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate the proliferative responses of primed allogeneic peripheral blood mononuclear cells on rechallenge with antigens. These findings may be important in the development and maintenance of the mucosal immunological activation of inflammatory bowel disease.

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Human intraepithelial lymphocytes

Cited by 30 publications

References 83 publications

Development of T-lymphocyte subpopulations in the postnatal chicken oviduct

Development of T-lymphocyte subpopulations in the postnatal chicken oviduct

Immunochemical Detection and Identification of Protein Adducts of Diclofenac in the Small Intestine of Rats: Possible Role in Allergic Reactions

Human colonic intraepithelial lymphocytes from patients with inflammatory bowel disease fail to down-regulate proliferative responses of primed allogeneic peripheral blood mononuclear cells after rechallenge with antigens

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