Human intestinal microbiota composition is associated with local and systemic inflammation in obesity

Verdam, Froukje J.; Fuentes, Susana; Jonge, Charlotte de; Zoetendal, Erwin G.; Erbil, Runi; Greve, Jan; Buurman, Wim A.; Vos, Willem M. de; Rensen, Sander S.

doi:10.1002/oby.20466

Cited by 488 publications

(394 citation statements)

References 39 publications

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“…Clostridium species increase the expression of regulatory T cells, which regulate the immune response in the large intestine, and may thus help to maintain the gut barrier function (29). Moreover, short chain fatty acids such as acetate and butyrate produced from Clostridium cluster IV were reportedly increased in non-obese people compared with obese people (30). Short chain fatty acids are a major energy source in colonic epithelial cells and enhance intestinal peristalsis.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women

Seura

Yoshino

Fukuwatari

2017

J Nutr Sci Vitaminol

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Summary Recent studies have shown that dietary content affects the health of the host by changing the gut microbiota. However, little is known about the association of microbiota composition with habitual diet in Japanese people. Here, we aimed to clarify the relationship between the fecal microbiota and habitual dietary intake of micronutrients, macronutrients and food groups in healthy young Japanese women. Analysis of fecal microbiota was performed by the terminal restriction fragment length polymorphism (T-RFLP) method, and a dietary survey was conducted over three consecutive days using a weighed food record method. T-RFLP pattern analysis divided the subjects into two clusters, where cluster A group had a high relative abundance of Bacteroides and Clostridium cluster IV, and cluster B group had a high relative abundance of Bifidobacterium and Lactobacillales. Cluster A group also had lower intakes of iron and vitamin K and higher intakes of mushrooms and snacks than cluster B group. Analysis of Spearman rank correlations found several significant relationships between fecal microbiota and intake of nutrients and food groups. Bifidobacterium was correlated with iron intake, and Clostridium cluster XI was negatively correlated with intakes of cholesterol and eggs. These results suggest that dietary habits may strongly affect Bifidobacterium, Bacteroides and Clostridium abundance in the gut microbiota of young Japanese women. This is the first study to show relationships between fecal microbiota and habitual dietary intake in Japanese people. Accumulation of results from similar studies will help to elucidate the relationships between dietary intake and diseases in Japanese people.

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Section: Discussionmentioning

confidence: 99%

The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women

Seura

Yoshino

Fukuwatari

2017

J Nutr Sci Vitaminol

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“…Microbiota recovery after faecal transplant in CDI S Fuentes et al (O'Keefe, 2010;Frazier et al, 2011;Verdam et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection

et al. 2014

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Recurrent Clostridium difficile infection (CDI) can be effectively treated by infusion of a healthy donor faeces suspension. However, it is unclear what factors determine treatment efficacy. By using a phylogenetic microarray platform, we assessed composition, diversity and dynamics of faecal microbiota before, after and during follow-up of the transplantation from a healthy donor to different patients, to elucidate the mechanism of action of faecal infusion. Global composition and network analysis of the microbiota was performed in faecal samples from nine patients with recurrent CDI. Analyses were performed before and after duodenal donor faeces infusion, and during a follow-up of 10 weeks. The microbiota data were compared with that of the healthy donors. All patients successfully recovered. Their intestinal microbiota changed from a low-diversity diseased state, dominated by Proteobacteria and Bacilli, to a more diverse ecosystem resembling that of healthy donors, dominated by Bacteroidetes and Clostridium groups, including butyrate-producing bacteria. We identified specific multi-species networks and signature microbial groups that were either depleted or restored as a result of the treatment. The changes persisted over time.Comprehensive and deep analyses of the microbiota of patients before and after treatment exposed a therapeutic reset from a diseased state towards a healthy profile. The identification of microbial groups that constitute a niche for C. difficile overgrowth, as well as those driving the reinstallation of a healthy intestinal microbiota, could contribute to the development of biomarkers predicting recurrence and treatment outcome, identifying an optimal microbiota composition that could lead to targeted treatment strategies.

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“…Decreased diversity and richness of microbiota has been linked to several disorders (Turnbaugh and Gordon, 2009;Verdam et al, 2013;Nylund et al, 2015). For instance, the diversity of microbial community and the abundance of butyrateproducing bacteria correlate negatively with the severity of atopic eczema in young children (Nylund et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the diversity of microbial community and the abundance of butyrateproducing bacteria correlate negatively with the severity of atopic eczema in young children (Nylund et al, 2015). Furthermore, reduced diversity and Bacteroidetes/Firmicutes ratio is associated with obesity (Ley et al, 2006;Turnbaugh and Gordon, 2009;Verdam et al, 2013). Importantly, aberrancies in earlylife microbiota development may impact the health status also later in life (Rautava et al, 2012;Nylund et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

et al. 2015

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The colonization pattern of intestinal microbiota during childhood may impact health later in life, but children older than 1 year are poorly studied. We followed healthy children aged 1-4 years (n = 28) for up to 12 months, during which a synbiotic intervention and occasional antibiotics intake occurred, and compared them with adults from the same region. Microbiota was quantified with the HITChip phylogenetic microarray and analyzed with linear mixed effects model and other statistical approaches. Synbiotic administration increased the stability of Actinobacteria and antibiotics decreased Clostridium cluster XIVa abundance. Bacterial diversity did not increase in 1-to 5-year-old children and remained significantly lower than in adults. Actinobacteria, Bacilli and Clostridium cluster IV retained child-like abundances, whereas some other groups were converting to adult-like profiles. Microbiota stability increased, with Bacteroidetes being the main contributor. The common core of microbiota in children increased with age from 18 to 25 highly abundant genus-level taxa, including several butyrate-producing organisms, and developed toward an adult-like composition. In conclusion, intestinal microbiota is not established before 5 years of age and diversity, core microbiota and different taxa are still developing toward adult-type configuration. Discordant development patterns of bacterial phyla may reflect physiological development steps in children.

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Human intestinal microbiota composition is associated with local and systemic inflammation in obesity

Abstract: Intestinal microbiota alterations in obese subjects are associated with local and systemic inflammation, suggesting that the obesity-related microbiota composition has a proinflammatory effect.

Cited by 488 publications

References 39 publications

The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women

The Relationship between Habitual Dietary Intake and Gut Microbiota in Young Japanese Women

Reset of a critically disturbed microbial ecosystem: faecal transplant in recurrent Clostridium difficile infection

Discordant temporal development of bacterial phyla and the emergence of core in the fecal microbiota of young children

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