Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses

Gallagher, Grant; Eskdale, Joyce; Jordan, William J.; Peat, Jon; Campbell, John; Boniotto, Michele; Lennon, Greig P.; Dickensheets, Harold; Donnelly, Raymond P.

doi:10.1016/j.intimp.2004.01.005

Cited by 125 publications

(113 citation statements)

References 64 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…60 The many associations seen at IL20, which is important in the inflammatory response 61 and in enhancing growth of multipotential hematopoietic progenitor cells, 62 suggest that this gene may be important in HCV clearance. IL10 and its neighboring paralogs (IL19 and IL20) may provide a link between host genetic polymorphisms and HCV clearance through modulating the TH1 and TH2 response in concert.…”

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance

et al. 2005

View full text Add to dashboard Cite

Hepatitis C virus (HCV) is an infectious blood-borne pathogen that usually persists as a chronic infection. However, approximately 15% of the time, patients can clear the virus, indicating that host differences could be critical in determining the course of HCV infection. The inflammatory response is crucial to resolving or failing to resolve an acute HCV infection. Some previous reports have implicated interleukin 10 (IL10) polymorphisms with successful anti-HCV therapy and natural viral clearance. We tested 54 single nucleotide polymorphisms (SNPs) in the IL10 region (7300 kb and 24 within the IL10 gene itself), which contains 13 genes including the IL10 immunomodulatory paralogs IL19, IL20, and IL24, for association with HCV clearance vs persistence. SNPs from two haplotype block regions, one at IL10 and the other from IL19/IL20, were associated with HCV clearance in African Americans (91 clearance cases and 183 chronically infected matched controls; P ¼ 0.05-0.002) while with expectation-maximization algorithm-reconstructed haplotypes, these associations remained (P ¼ 0.05-0.002). However, no significant associations were detected in European Americans (108 clearance and 245 chronic). Our results indicate that variants of the immunomodulatory IL10 and IL19/IL20 genes may be involved in natural clearance of HCV in the African-American population.

show abstract

Section: Discussionmentioning

confidence: 99%

Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance

et al. 2005

View full text Add to dashboard Cite

show abstract

“…Recently, we and others have demonstrated evidence for activation of the Th2 response by IL-19 [38,39]. Liao et al showed an up-regulation of Th2 cytokines in mice to which IL-19 had been administered [38], along with the observation that asthma patients have elevated serum IL-19 levels.…”

Section: Il-19 Up-regulates Il-10 Production In Monocytederived DCmentioning

confidence: 92%

Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10

et al. 2005

Self Cite

View full text Add to dashboard Cite

IL‐19 is a novel, recently identified member of the IL‐10 family of cytokines. We identified IL‐10 as a cytokine that was strongly induced in IL‐19‐stimulated PBMC. IL‐19‐induced IL‐10 secretion was dose‐dependent and could be detected in culture supernatants after 3 h of stimulation. Furthermore, quantitative RT‐PCR analysis demonstrated that IL‐19 stimulation increased the level of IL‐10 mRNA present within cells, suggesting that IL‐19 is a transcriptional activator of IL‐10. IL‐19 was also able to induce its own expression, with IL‐10 potently down‐regulating this IL‐19 ‘auto‐induction’. LPS induction of IL‐19 expression was also regulated by IL‐10, demonstrating that IL‐10 is likely an important regulator of human IL‐19 induction. Maturation of dendritic cells from human PBMC in the presence of IL‐19 resulted in an increase in IL‐10 levels within these cells, whereas IL‐12 was not affected. These results advance our understanding of the function of this novel cytokine and its regulation within the human immune system, in addition to providing a new insight into the control of the important immunoregulatory cytokine, IL‐10.

show abstract

“…Allergic asthma mouse models have suggested that IL-19 can induce the expression of T H 2 cytokines from T cells, indicating that IL-19 might play an essential role in the dysregulation of mucosal immunity by shifting the T H 1/T H 2 balance. 11,13 Although the primary source of IL-19 appears to be inflammatory cells, especially activated macrophages, other cell types, such as keratinocytes and bronchial epithelia, have also been shown to produce IL-19 in vitro under stimulatory conditions. The increased expression in keratinocytes might contribute to psoriasis.…”

mentioning

confidence: 99%

“…17 Although IL-19 induction in asthmatic patients' sera might be related to the induction of a T H 2 response, its cellular source has not yet been identified. 12,13 There is emerging evidence that points to an increase in both IL-17A and IL-19 levels in asthmatic patients. 11,18 We recently demonstrated that IL-17A is a potent inducer of IL-19 expression in vitro by well-differentiated primary normal human bronchial epithelial (NHBE) cells.…”

mentioning

confidence: 99%

Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma

Huang

Wachi

Thai

et al. 2008

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

show abstract

Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses

Cited by 125 publications

References 64 publications

Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance

Single nucleotide polymorphisms and haplotypes in the IL10 region associated with HCV clearance

Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10

Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: Important implications in asthma

Contact Info

Product

Resources

About