Human Inter-α-Trypsin Inhibitor Heavy Chain H3 Gene

Diarra‐Mehrpour, Maryam; Sarafan, Nasrin; Bourguignon, Jeannette; Bonnet, F; Bost, Fréd́eric; Martín, J. P.

doi:10.1074/jbc.273.41.26809

Cited by 15 publications

(3 citation statements)

References 54 publications

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“…The borders of the first two areas in PH5P fairly match the borders previously proposed for the catalytic domain in PARP and the hallmark of HxPs in the IαI family [1, 9]. These areas in PARP and HxPs are encoded by a set of 12 exons each [13, 14]. Therefore the PH5P gene likely resulted, at least partly, from the assembly of two sets of exons derived from the ancestral PARP and ITIH genes.…”

Section: A Protein With Iαi‐ and Parp‐related Domains: Ph5psupporting

confidence: 79%

The nuclear protein PH5P of the inter‐α‐inhibitor superfamily: a missing link between poly(ADP‐ribose)polymerase and the inter‐α‐inhibitor family and a novel actor of DNA repair?

Lesné¹,

Risler²,

Nagase³

et al. 1999

FEBS Letters

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Poly(ADP-ribose)polymerase is a nuclear NADdependent enzyme and an essential nick sensor involved in cellular processes where nicking and rejoining of DNA strands are required. The inter-K K-inhibitor family is comprized of several plasma proteins that all harbor one or more so-called heavy chains designated H1^H4. The latter originate from precursor polypeptides H1P^H4P whose upper two thirds are highly homologous. We now describe a novel protein that includes (i) a so-called BRCT domain found in many proteins involved in DNA repair, (ii) an area that is homologous to the NAD-dependent catalytic domain of poly(ADP-ribose)polymerase, (iii) an area that is homologous to the upper two thirds of precursor polypeptides H1P^H4P and (iv) a proline-rich region with a potential nuclear localization signal. This protein now designated PH5P points to as yet unsuspected links between poly(ADPribose)polymerase and the inter-K K-inhibitor family and is likely to be involved in DNA repair.z 1999 Federation of European Biochemical Societies.

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Section: A Protein With Iαi‐ and Parp‐related Domains: Ph5psupporting

confidence: 79%

The nuclear protein PH5P of the inter‐α‐inhibitor superfamily: a missing link between poly(ADP‐ribose)polymerase and the inter‐α‐inhibitor family and a novel actor of DNA repair?

Lesné¹,

Risler²,

Nagase³

et al. 1999

FEBS Letters

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“…The homologous HCs consist of five members (HC1–5), with HC1, HC3, and HC4 residing in a closely linked region on chromosome 3p21 (3), whereas HC2 and HC5 are arranged in tandem on chromosome 10p15 (4). HC1, HC2, and HC3 contain a conserved proteolytic cleavage site in their C-terminal regions and are able to link to the single chondroitin sulfate (CS) chain of the proteoglycan bikunin via covalent (ester) bonds after they are released from their HC precursor (1, 2, 5, 6).…”

Section: Introductionmentioning

confidence: 99%

Constitutive Expression of Inter-α-inhibitor (IαI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex

Zhang

Day

et al. 2012

Journal of Biological Chemistry

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Background: The heavy chain-hyaluronan (HC-HA) complex from amniotic membrane (AM) has anti-inflammatory, anti-scarring, and anti-angiogenic actions.Results: AM epithelial and stromal cells constitutively expressed IαI and TSG-6 supporting the production of HC-HA.Conclusion: AM is an extrahepatic tissue constitutively producing its own IαI and HC-HA complex.Significance: HC-HA endogenously produced by AM may play an important protective role during fetal development.

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“…The ITIH5 protein belongs to the ITIH family of serine proteases, each of which is distinguished by the presence of a unique heavy chain in a complex with a light chain consisting of the core protein “bikunin,” a two tandem repeat of kunitz encoded by the AMBP gene 118,119 . The precursor ITIH5 is a 942 amino acid protein with a molecular mass of approximately 105 KDa consisting of the heavy chain encoded by the ITIH5 gene linked to the light chain bikunin via a single chondroitin sulfate chain 120–124 . Multiple members of the ITIH family have been reported to contribute to the stabilization of the ECM by direct interaction with various ECM components, such as hyaluronic acid 118,119,125,126 .…”

Section: Inter-α-trypsin Inhibitor Heavy Chainmentioning

confidence: 99%

Metastasis Suppressor Genes in Pancreatic Cancer

et al. 2021

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Pancreatic cancer, especially pancreatic ductal adenocarcinoma (PDAC), has for long remained a deadly form of cancer characterized by high mortality rates resulting from metastasis to multiple organs. Several factors, including the late manifestation of the disease, partly amplified by lack of efficient screening methods, have hampered the drive to design an effective therapeutic strategy to treat this deadly cancer. Understanding the biology of PDAC progression and identifying critical genes regulating these processes are essential to overcome the barriers toward effective treatment. Metastasis suppressor genes have been shown to inhibit multiple steps in the metastatic cascade without affecting primary tumor formation and are considered to hold promise for treating metastatic cancers. In this review, we catalog the bona fide metastasis suppressor genes reported in PDAC and discuss their known mechanism of action.

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Human Inter-α-Trypsin Inhibitor Heavy Chain H3 Gene

Cited by 15 publications

References 54 publications

The nuclear protein PH5P of the inter‐α‐inhibitor superfamily: a missing link between poly(ADP‐ribose)polymerase and the inter‐α‐inhibitor family and a novel actor of DNA repair?

The nuclear protein PH5P of the inter‐α‐inhibitor superfamily: a missing link between poly(ADP‐ribose)polymerase and the inter‐α‐inhibitor family and a novel actor of DNA repair?

Constitutive Expression of Inter-α-inhibitor (IαI) Family Proteins and Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) by Human Amniotic Membrane Epithelial and Stromal Cells Supporting Formation of the Heavy Chain-Hyaluronan (HC-HA) Complex

Metastasis Suppressor Genes in Pancreatic Cancer

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