Human insulin and hypoglycaemia

Egger, Matthias; Smith, George Davey; Teuscher, A; Kriegstein, E von; Colagiuri, Stephen; Miller, John J.; Petocz, Peter

doi:10.1016/0140-6736(92)92387-u

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…All but one[61] provided data on hypoglycaemic events, this study simply reporting no events during the investigation. Four studies found no differences in the frequency of hypoglycaemia[2–64]. Two studies reported a statistically insignificantly increased frequency of hypoglycaemia in subjects on ‘human’ insulin as compared to those on insulin of animal origin[65–66].…”

Section: Resultsmentioning

confidence: 99%

“…Nineteen publications[6–92] compare a period of animal insulin treatment to one of ‘human’ insulin treatment in the same subject. Nine of these studies[75–77,81–83,85–86,88–91] reported no difference between insulin species while a further three[78–79,92] found fewer hypogycaemic episodes with ‘human’ insulin and/or greater awareness of hypoglycaemia.…”

Section: Resultsmentioning

confidence: 99%

“…This reported impaired awareness of hypoglycaemia with ‘human’ insulin treatment has resulted in considerable discussion in both the medical[6–7] and lay press[8], and has precipitated numerous studies, case reports and reviews. The purpose of this present paper is to draw together the existing published information in the form of a systematic review.…”

Section: Introductionmentioning

confidence: 99%

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Hypoglycaemia induced by exogenous insulin –‘human’ and animal insulin compared

et al. 2000

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Evidence does not support the contention that treatment with 'human' insulin per se affects the frequency, severity or symptoms of hypoglycaemia. However, a number of studies, mainly those of less rigorous design, describe an effect when people are transferred from animal insulin to 'human' insulin. It is not possible to state how common this is or whether the phenomenon is specific to 'human' insulin or an effect resulting from stricter glycaemic control (perhaps compounded, in some cases, by neurological complications in long-standing diabetes). This remaining uncertainty makes it essential that insulin from animal sources continues to be available so that clinicians and patients may retain this choice of treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypoglycaemia induced by exogenous insulin –‘human’ and animal insulin compared

et al. 2000

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“…Other reports regarding the frequency and/or specific symptoms of hypoglycemia in people who switched to human insulin have been conflicting (3)(4)(5)(6). The purpose of the current inquiry is to evaluate whether there has been a change in reported frequency of hypoglycemic reactions in a large, well-defined cohort of people with diabetes who have been followed during the transition in patterns of use from animal to human insulin.…”

mentioning

confidence: 99%