Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate

Monsé, Christian; Hagemeyer, Olaf; Kampen, V. van; Raulf, Monika; Weiß, Tobias; Menne, Eleonore; Jettkant, Birger; Kendzia, Benjamin; Merget, R.; Brüning, Thomas; Bünger, Jürgen

doi:10.1007/5584_2020_572

Cited by 8 publications

(10 citation statements)

References 28 publications

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“…This may cause the plate to shake and even fracture in serious cases. The maximum deformation of the plate is analyzed, and the formula is shown in (6).…”

Section: The Migration Area and The Collection Areamentioning

confidence: 99%

“…However, patients are usually resistant to this method because it causes damage to skin tissues and is accompanied by an obvious stinging sensation, and there are unsafe factors that can easily cause infection. Therefore, the development of a noninvasive detection technique has become a hot spot in medical research, and breath analysis, as a new noninvasive detection technique, has been favored by many researchers [2][3][4][5][6][7][8]. Studies have shown that the human breath contains more than 1000 volatile organic compounds (VOCs) [9].…”

Section: Introductionmentioning

confidence: 99%

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Acetone Sensor Based on FAIMS-MEMS

et al. 2021

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In this paper, to address the problems of large blood draws, long testing times, and the inability to achieve dynamic detection of invasive testing for diabetes, stemming from the principle that type 1 diabetic patients exhale significantly higher levels of acetone than normal people, a FAIMS-MEMS gas sensor was designed to detect acetone, which utilizes the characteristics of high sensitivity, fast response, and non-invasive operation. It is prepared by MEMS processes, such as photolithography, etching, and sputtering, its specific dimensions are 4000 μm in length, 3000 μm in width and 800 μm in height and the related test system was built to detect acetone gas. The test results show that when acetone below 0.8 ppm is introduced, the voltage value detected by the sensor basically does not change, while when acetone gas exceeds 1.8 ppm, the voltage value detected by the sensor increases significantly. The detection accuracy of the sensor prepared by this method is about 0.02 ppm/mV, and the voltage change can reach 1 V with a response time of 3 s and a recovery time of 4 s when tested under 20 ppm acetone environment; this has good repeatability and stability, and has great prospects in the field of non-invasive detection of type 1 diabetes.

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“…This may cause the plate to shake and even fracture in serious cases. The maximum deformation of the plate is analyzed, and the formula is shown in (6).…”

Section: The Migration Area and The Collection Areamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Acetone Sensor Based on FAIMS-MEMS

et al. 2021

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“…Since the Danish zinc report was written, other papers have been published on the subject. In our second ZnO study (Monsé et al 2021 ), 16 subjects were exposed to nano- and micro-sized ZnO at 2.0 mg/m 3 and sham for 2 h each. The dose of ZnO administered (2.0 mg/m 3 × 2 h) was derived from our first study (1.0 mg/m 3 × 4 h) (Monsé et al 2018 ) to yield mild systemic inflammatory responses and to minimize fever reactions as observed at the highest ZnO dose in our first ZnO study (2.0 mg/m 3 × 4 h).…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?

et al. 2023

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Exposure to airborne substances such as gases, vapours, and particles remains a relevant health risk in many workplaces. A current topic and cause for discussion is the investigation of the health effects of particles containing zinc oxide (ZnO). Among other data, those collected from our study on human exposure data of ZnO in 2018 prompted the National Research Centre for the Working Environment 2021 to formulate a new, sharply lowered proposed occupational exposure limit (OEL) for zinc in workplaces. Since the publication of the Danish report, further studies have been conducted with ZnO. In the following text, all arguments for deriving this new limit value for zinc from the report are discussed, extended with the more recent data since 2018. It should be noted that especially the application of time extrapolation factors needs further discussion and harmonization between regulatory authorities. From our point of view, the data situation can justify a higher OEL for zinc than that proposed by the Danish National Research Centre for the Working Environment.

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“…ENMs stimulate or suppress immune responses depending on their specific properties (surface chemistry, structure, agglomeration), and at present, a large number of studies have focused on the toxicity and impacts of nZnO and nAg in different lung models [ 13 , 14 , 15 ]. A study on human volunteers showed that two hours of inhalation exposure of 2.0 mg/m 3 nZnO led to increased numbers of neutrophils, monocytes, and acute-phase proteins in the blood twenty-two hours after the exposure, and these effects lasted for three days after the exposure [ 16 ]. Occupationally relevant levels of 4.9 or 1.1 mg/m 3 nZnO (51 nm or 48 nm) exposure to rats for 1, 7, and 30 days induced inflammatory and oxidative responses [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs

Zhao

Wang

Ilves

et al. 2023

IJMS

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Consumers and manufacturers are exposed to nanosized zinc oxide (nZnO) and silver particles (nAg) via airways, but their biological effects are still not fully elucidated. To understand the immune effects, we exposed mice to 2, 10, or 50 μg of nZnO or nAg by oropharyngeal aspiration and analyzed the global gene expression profiles and immunopathological changes in the lungs after 1, 7, or 28 days. Our results show that the kinetics of responses varied in the lungs. Exposure to nZnO resulted in the highest accumulation of F4/80- and CD3-positive cells, and the largest number of differentially expressed genes (DEGs) were identified after day 1, while exposure to nAg caused peak responses at day 7. Additionally, nZnO mainly activated the innate immune responses leading to acute inflammation, whereas the nAg activated both innate and adaptive immune pathways, with long-lasting effects. This kinetic-profiling study provides an important data source to understand the cellular and molecular processes underlying nZnO- and nAg-induced transcriptomic changes, which lead to the characterization of the corresponding biological and toxicological effects of nZnO and nAg in the lungs. These findings could improve science-based hazard and risk assessment and the development of safe applications of engineered nanomaterials (ENMs), e.g., in biomedical applications.

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Human Inhalation Study with Zinc Oxide: Analysis of Zinc Levels and Biomarkers in Exhaled Breath Condensate

Cited by 8 publications

References 28 publications

Acetone Sensor Based on FAIMS-MEMS

Acetone Sensor Based on FAIMS-MEMS

Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?

Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs

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