Abstract:The first exposures to influenza have been shown to bias the immune system towards a certain strain which is then boosted by subsequent infection and vaccination throughout life. The impact of repeated stimulation of hemagglutinin (HA) epitopes of the CD4 T cell repertoire is unknown. We are interested in the CD4 T cells specific to conserved regions of HA as the conserved stalk region is a target for new vaccine designs and antibodies to HA are a correlate of protection from infection. We are also interested … Show more
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