Human Infections with Thymine-Requiring Bacteria

Maskell, Rosalind; Okubadejo, O. A.; Payne, R.H.; Pead, Linda

doi:10.1099/00222615-11-1-33

Cited by 47 publications

(25 citation statements)

References 13 publications

(16 reference statements)

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“…One of these would, strictly speaking, include the chromosomal location of transposon Tn7 (62,92). Second, low-level resistance to TMP was found to develop from a mutational loss in bacteria of their ability to methylate deoxyuridylic acid to thymidylic acid, making them dependent on an external supply of thymine (52,83,99). This mutation relieves the cellular DHFR from its major task of regenerating the tetrahydrofolate involved in the formation of N 5 ,N 10 -methylenetetrahydrofolate, which is oxidized in the deoxyuridylate methylation process.…”

Section: Spread Of Tmp and Sul Resistancementioning

confidence: 99%

Trimethoprim and sulfonamide resistance

Huovinen¹,

Sundström²,

Swedberg³

et al. 1995

Antimicrob Agents Chemother

441

314

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Section: Spread Of Tmp and Sul Resistancementioning

confidence: 99%

Trimethoprim and sulfonamide resistance

Huovinen¹,

Sundström²,

Swedberg³

et al. 1995

Antimicrob Agents Chemother

441

314

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“…Such strains have been isolated from the urine of patients undergoing Tmp or cotrimoxazole therapy (18,19,23). Our experiments (Fig.…”

mentioning

confidence: 99%

“…Because urine samples from infected individuals sometimes contain thymine derivatives (18,19,25) which adversely affect Tmp activity (3,4), it was of interest to us to assess the effect of thymine on the antibacterial activity of Ramp+Tmp in urine. Figure 4 compares the activities of Ramp, Tmp, and Ramp+Tmp on E. coli L766 growing in urine with and without the addition of 2 jig of thymine per ml.…”

mentioning

confidence: 99%

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Rifampin plus trimethoprim: bactericidal activity and suppression of resistance in human urine in vitro

Goldstein¹,

Ripamonti²,

Bolzoni³

et al. 1979

Antimicrob Agents Chemother

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The bactericidal effect of a combination of rifampin (Ramp) and trimethoprim (Tmp) was studied using dense cultures of test organisms, including some urinary pathogens, growing in human urine. Drug concentrations used were similar to those attainable in human urine. The combination was more effective than the individual drugs and than a combination of Tmp plus sulfamethoxazole (Smx). Tmp was bactericidal in urine and blocked the emergence of Ramp-resistant bacteria. Ramp was responsible for most of the bactericidal action of the combination but also potentiated the bactericidal activity of Tmp. Ramp suppressed the selection of thy- (Tmp-resistant) (6,(13)(14)(15)(16). One should recognize, however, particularly when comparing the efficacies of different antibacterial combinations, that upon administration of therapeutic doses the concentrations reached at the site of infection are generally much higher than those for which synergy or additivity can be demonstrated.

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“…Marked differences in synthetic activity have been reported for variants of Escherichia coli (Borderon and Horodniceanu, 1978;Maskell et al, 1978). Some of these differences involve respiratory pathways (Cox and Gibson, 1966;Wu!ff, 1967).…”

Section: Discussionmentioning

confidence: 99%

Colonial Variants of Proteus Species: Their Growth Requirements, Biochemical Characters and Resistance to Antibacterial Agents

Klemperer

Al-Dujaili

Brown

1982

Journal of Medical Microbiology

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SUMMARY. Stable small-colony variants of Proteus species were isolated and characterised. They differed from typical organisms in their morphology, biochemical properties and drug resistance. They were found most frequently in culture media of low osmolarity. Their growth rate was depressed at high concentrations of salts, which had only a small effect on typical organisms. This may be important in the routine isolation of Proteus spp. and in testing of disinfectants.

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Human Infections with Thymine-Requiring Bacteria

Cited by 47 publications

References 13 publications

Trimethoprim and sulfonamide resistance

Trimethoprim and sulfonamide resistance

Rifampin plus trimethoprim: bactericidal activity and suppression of resistance in human urine in vitro

Colonial Variants of Proteus Species: Their Growth Requirements, Biochemical Characters and Resistance to Antibacterial Agents

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