Human infection with highly pathogenic H5N1 influenza virus

Gambotto, Andrea; Barratt‐Boyes, Simon M.; Jong, Menno D. de; Neumann, Gabriele; Kawaoka, Yoshihiro

doi:10.1016/s0140-6736(08)60627-3

Cited by 281 publications

(234 citation statements)

References 161 publications

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“…26 The H5N1 avian virus that has caused sporadic infections in humans since 2003, is considered to pose the greatest pandemic threat if the host range alters from poultry, in which it is highly lethal, to man by the acquisition of adaptive mutations. 27,28 In cases where this H5N1 virus has infected humans, the level of mortality has been very high. Overall, the case fatality rate (CFR) is approximately 60% but this is quite different depending on the country; for example in Egypt the CFR is 29% while in Indonesia it is a staggering 83% (www.who.int/csr/disease/ avian_influenza/country/cases_table_2009_07_01/en/index.…”

Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

“…Avian H5N1 has presented a serious threat evidenced by sporadic and limited infection of humans in 1997 in Hong Kong and its re-emergence in 2003 in Asia. 27,28,[32][33][34][35] Due to the unpredictability of whether this virus would become pandemic and the potentially dire consequences if it did, the focus of the effort was for vaccine manufacturers this purpose. The error rate of the influenza polymerase complex is considered high amongst proof-reading enzymes and in any one round of replication the chance of a given nucleotide change has been calculated to be ∼10 -4 .…”

Section: Pre-pandemic and Pandemic Vaccination Strategiesmentioning

confidence: 99%

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Pre-pandemic and pandemic influenza vaccines

Rockman¹,

Brown²

2010

Human Vaccines

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Section: O N O T D I S T R I B U T Ementioning

confidence: 99%

Section: Pre-pandemic and Pandemic Vaccination Strategiesmentioning

confidence: 99%

Pre-pandemic and pandemic influenza vaccines

Rockman¹,

Brown²

2010

Human Vaccines

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“…Clade 2.2 of the virus spread globally throughout Europe, the Middle East and Africa after first appearing in Asia in 2005 (Chen et al, 2006;Webster and Govorkova, 2006;Scotch et al, 2013;Li et al, 2014). Because of the high lethality and virulence of H5N1, its endemic presence, its increasingly large host reservoir, and its significant rate of mutation, it is currently one of the world's greatest pandemic threats (Gambotto et al, 2008;Tsang et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Climate change suggests a shift of H5N1 risk in migratory birds

Tian

Zhou

Dong

et al. 2015

Ecological Modelling

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a b s t r a c tMigratory birds are considered to have played an important role in the spread of highly pathogenic avian influenza H5N1. However, how bird species are expected to modify their wintering sites in response to climate change, and in turn affect the geographic distribution of the risk associated with H5N1 outbreaks, is unknown. We explored the association between past climate variability and H5N1 outbreaks that were attributed to migratory birds from 2005 to 2009. We then predicted the distribution of risk associated with H5N1 outbreaks based on future climate change scenarios. Overlapping the probabilities of bird distribution and H5N1 outbreaks produced final emergence risk. Our results suggest that minimum daily temperature in the winter (−15 to -11 • C, 15 to 17 • C) and maximum daily temperature in the summer (12 to 15 • C, 30 to 35 • C) governed wild bird migratory routes, while high mean air pressure and low mean specific humidity in the winter impacted the outbreaks of H5N1 among migratory birds. By the end of 2030, Europe may be at higher risk for H5N1 outbreaks in January and February. Northern Africa and Southern and Western Asia will likely be a higher risk for H5N1 outbreaks from April to June. Our findings suggest a potential shift in H5N1 risk from Southeast Asia to the western part of the world due to climate change. The results of this study could be used to inform policy in the area of H5N1 outbreak detection and preparedness.

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“…Influenza A virus (IAV) remains a global health concern because of the emergence of novel virus subtypes or strains potentially capable of causing pandemics [1,2,3]. Due to high mutation rate during IAV replication, emergence of antiviral drug resistance is a major concern in influenza antiviral treatment [4], and highlights the need for new drug development.…”

Section: Introductionmentioning

confidence: 99%

Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding

Liu

Xiang

Guo

et al. 2014

Biochemical and Biophysical Research Communications

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Influenza A virus (IAV) assembly and budding on host cell surface plasma membrane requires actin cytoskeleton reorganization. The underlying molecular mechanism involving actin reorganization remains unclarified. In this study, we found that the natural antiviral compound petagalloyl glucose (PGG) inhibits F-actin reorganization in the host cell membrane during the late stage of IAV infection, which are associated with the suppression of total cofilin-1 level and its phosphorylation. Knock-down of cofilin-1 reduces viral yields. These findings provide the first evidence that cofilin-1 plays an important role in regulating actin reorganization during IAV assembly and budding.

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Human infection with highly pathogenic H5N1 influenza virus

Cited by 281 publications

References 161 publications

Pre-pandemic and pandemic influenza vaccines

Pre-pandemic and pandemic influenza vaccines

Climate change suggests a shift of H5N1 risk in migratory birds

Cofilin-1 is involved in regulation of actin reorganization during influenza A virus assembly and budding

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