Human in vitro percutaneous absorption of bisphenol S and bisphenol A: A comparative study

Champmartin, Catherine; Marquet, Fabrice; Chedik, Lisa; Décret, Marie-Josèphe; Aubertin, Matthieu; Ferrari, Elisabeth; Grandclaude, Marie-Christine; Cosnier, Frédéric

doi:10.1016/j.chemosphere.2020.126525

Cited by 25 publications

(12 citation statements)

References 36 publications

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“…However, dermal absorption of BPS is very limited. Based on an in vitro study by Champmartin et al (2020) [ 60 ], it has been assumed that the dermal route will contribute very little to the overall exposure to BPS. Lastly, the relative contribution of the inhalation route may also be expected to be low, based on BPS physical-chemical properties (low vapor pressure) and by analogy with previous BPA risk assessments.…”

Section: Resultsmentioning

confidence: 99%

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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Within the European Joint Programme HBM4EU, Human Biomonitoring Guidance Values (HBM-GVs) were derived for several prioritised substances. In this paper, the derivation of HBM-GVs for the general population (HBM-GVGenPop) and workers (HBM-GVworker) referring to bisphenol S (BPS) is presented. For the general population, this resulted in an estimation of the total urinary concentration of BPS of 1.0 µg/L assuming a 24 h continuous exposure to BPS. For workers, the modelling was refined in order to reflect continuous exposure during the working day, leading to a total urinary concentration of BPS of 3.0 µg/L. The usefulness for risk assessment of the HBM-GVs derived for BPS and bisphenol A (BPA) is illustrated. Risk Characterisation Ratios (RCRs) were calculated leading to a clear difference between risk assessments performed for both bisphenols, with a very low RCR regarding exposure to BPA., contrary to that obtained for BPS. This may be due to the endocrine mediated endpoints selected to derive the HBM-GVs for BPS, whereas the values calculated for BPA are based on the temporary Tolerable Daily Intake (t-TDI) from EFSA set in 2015. A comparison with the revised TDI recently opened for comments by EFSA is also discussed. Regarding the occupational field, results indicate that the risk from occupational exposure to both bisphenols cannot be disregarded.

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Section: Resultsmentioning

confidence: 99%

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Meslin

Beausoleil

Zeman

et al. 2022

Toxics

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“…BPS metabolism in humans is known and is mainly phase II conjugation, as observed for BPA metabolism. We deemed conjugation by the skin negligible, which has recently been supported for BPS . Thus, we did not add a deconjugation step.…”

Section: Discussionmentioning

confidence: 98%

“…We deemed conjugation by the skin negligible, which has recently been supported for BPS. 57 Thus, we did not add a deconjugation step. Our method could be further developed to include metabolites for all color developers, once data on D-8 and PF201 metabolism become available.…”

Section: Discussionmentioning

confidence: 99%

Simultaneous Quantification of Bisphenol A, Its Glucuronide Metabolite, and Commercial Alternatives by LC-MS/MS for In Vitro Skin Absorption Evaluation

Reale

Fustinoni

Mercadante

et al. 2020

Chem. Res. Toxicol.

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Bisphenol A (BPA) is the most used color developer in thermal paper products such as cashiers' receipts, followed by Bisphenol S (BPS), Wincon 8 (D-8), and Pergafast 201 (PF201). These chemicals can migrate from the paper onto the skin and possibly be absorbed and metabolized. Until now, D-8 and PF201 have not been analyzed in biological matrices, nor has a method been developed to simultaneously quantify them even though they are often found as mixtures. Our aim was to develop and validate a method to quantify BPA, its glucuronide metabolite (BPA-G), BPS, D-8 and PF201 in in vitro skin absorption samples. After solid-phase extraction and reversed-phase chromatography, we quantified the substances in saline that had been in contact with human dermis for 24 h using a triple quadrupole mass detector equipped with an electrospray ionization source. We assessed the method in three in vitro skin absorption assays using ex-vivo human skin from one skin donor per test substance. The quantification ranges of our method were 0.2 -200 µg/L for BPA and 0.2 -20 µg/L for BPA-G, BPS, D-8, and PF201. Accuracies were within ±8% of nominal concentrations. Intra-day and total precisions (%RSD) were <10% for all analytes, except for BPA in low-concentration quality control solutions (low QCs) (12.2% and 15.5%, respectively). Overall, the process efficiency was 100-113% for all analytes, except BPS low and high QCs (80% and 71%, respectively) and BPA low QCs (134%). The absorbed dose ranged from 0.02% to 49% depending on the test substance, and was not determinable for PF201. This is the first analytical method to quantify simultaneously BPA, BPA-G, and BPA alternatives in saline from in vitro skin absorption samples.

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“…As shown in ( Table 3 ), BPS has a lower log P value than BPA and bisphenol F (BPF) due to its hydrophilic moiety. A study using reconstructed human epidermis to compare the percutaneous absorption of BPA and BPS revealed that the permeability coefficient of BPS was significantly lower than that of BPA [ 20 – 22 ]. These findings were similar to the findings of the present study, the log P values of BPA, BPF, and BPS were 3.40, 2.91, and 1.65, respectively.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal tract and skin permeability of chemicals in consumer products using parallel artificial membrane permeability assay (PAMPA)

Park

Lee

Park

2021

Environ Anal Health Toxicol

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Some chemicals commonly used in personal care products, household items, food vessels, cosmetics, and other consumer products are potentially harmful, and several reviews of epidemiological studies have suggested the associations between the chemical exposure from consumer products, and respiratory diseases, skin sensitization, and reproductive problems. Therefore, risk assessment is essential for management of consumer products safety. Necessarily, the estimation of human exposure is an essential step in risk assessment, and the absorption rate of those chemicals via the gastrointestinal tract, respiratory tract, and skin are very critical in determining the internal dose of the exposed chemicals. In this study, parallel artificial membrane permeability assays (PAMPA) for the gastrointestinal tract and skin were performed to evaluate the permeability of parabens (4-hydroxybenzoic acid, methyl-, propyl-, and butyl paraben), bisphenols (bisphenol A, bisphenol F, and bisphenol S), isothiazolinones (methyl-, chloromethyl-, benz-, octyl-, and dichlorooctyl isothiazolinone), and phthalates [diethyl-, dibutyl-, Di-isononyl-, and bis(2-ethylhexyl) phthalate]. Lipid solubility of test chemicals indicated by log P values was shown as the most critical factor and showed a positive association with the permeability of parabens, bisphenols, and isothiazolinones in PAMPA assay. However, phthalate showed a reverse-association between lipophilicity and permeability. The permeability of all the tested chemicals was higher in the gastrointestinal tract membrane than in the skin membrane. The pH in donor solution did not show significant effects on the permeability in all the chemicals, except the chemicals with a free hydrophilic moiety in their chemical structures.

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Human in vitro percutaneous absorption of bisphenol S and bisphenol A: A comparative study

Cited by 25 publications

References 36 publications

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Human Biomonitoring Guidance Values (HBM-GVs) for Bisphenol S and Assessment of the Risk Due to the Exposure to Bisphenols A and S, in Europe

Simultaneous Quantification of Bisphenol A, Its Glucuronide Metabolite, and Commercial Alternatives by LC-MS/MS for In Vitro Skin Absorption Evaluation

Gastrointestinal tract and skin permeability of chemicals in consumer products using parallel artificial membrane permeability assay (PAMPA)

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