Human immunoglobulin therapy for preeclampsia associated with lupus anticoagulant and anticardiolipin antibody

Vl, Katz; Thorp, Jr; Watson, W H; Fowler, Leanne H.; Heine, R. Phillips

doi:10.1097/00006250-199011000-00071

Cited by 10 publications

(7 citation statements)

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“…Katz et a1 (2) reported successful prolongation of a pregnancy complicated by the APS and preeclampsia at 24 weeks' gestation using intravenous human immunoglobulin therapy. Lupus anticoagulant was suppressed and anticardiolipin titres were partially suppressed and the preeclampsia stabilized.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy Complicated by the Antiphospholipid Syndrome

Munday

Jones

1993

Aust NZ J Obst Gynaeco

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A patient with previously undiagnosed antiphospholipid syndrome (APS) developed atypical severe preeclampsia at 31 weeks' gestation. Other complications of pregnancy included intrauterine growth retardation, thrombocytopenia and fetal distress necessitating urgent delivery of a live infant. There was a prior history of unexplained jugular venous thrombosis. Prophylaxis against thrombosis was commenced immediately postoperatively and no postpartum complications occurred. Recent evidence supports the use of antepartum prophylaxis with low dose heparin in patients with APS. The role of low dose aspirin, either alone or in combination with heparin, is yet to be determined. Human immunoglobulin may be useful in selected cases. Early diagnosis is a key factor in their management.

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Section: Discussionmentioning

confidence: 99%

Pregnancy Complicated by the Antiphospholipid Syndrome

Munday

Jones

1993

Aust NZ J Obst Gynaeco

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“…Both GVHD-related and classical autoimmune conditions often improve upon treatments that have been found successful also in preeclampsia and HELLP syndrome. Three examples are the treatment with corticosteroids, removal of autoantibody abnormalities via plasmapheresis, and the competitive binding of autoantibodies with intravenous immunoglobulin (Katz et al, 1990;Martin et al, 1990;Martin et al, 2006). Considering the significant degree of bidirectional cell traffic during pregnancy, one can speculate that, in analogy to GVHD, the autoimmune phenomena, seen in association with preeclampsia, may be immune responses by fetal lymphocytes to epitopes shared by mother and fetus.…”

Section: The Association Between Preeclampsia and Autoimmunitymentioning

confidence: 99%

T Lymphocyte Characteristics and Immune Tolerance During Human Pregnancy

Toldi¹,

Treszl²,

Vásárhelyi³

2011

Autoimmune Disorders - Pathogenetic Aspects

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“…Other systemic therapies such Heparin and Coumadin and gammaglobulin have also been tried with variable efficacy 14,21 …”

Section: Diseases Caused By Dermal Thrombimentioning

confidence: 99%

Inflammatory Ulcers

Kerdel¹

1993

The Journal of Dermatologic Surgery and Oncology

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A large number of diseases can eventuate in cutaneous ulceration. This article will review inflammatory disorders which by their nature can directly produce cutaneous breakdown and ulcer formation. Major emphasis is given to those disorders where recent knowledge has improved our understanding of the condition or where new therapeutic agents or maneuvers have become available. This later group consists of vasculitis, disorders caused by small vessel thrombi or embolus and pyoderma gangrenosusm.

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Human immunoglobulin therapy for preeclampsia associated with lupus anticoagulant and anticardiolipin antibody

Cited by 10 publications

References 0 publications

Pregnancy Complicated by the Antiphospholipid Syndrome

Pregnancy Complicated by the Antiphospholipid Syndrome

T Lymphocyte Characteristics and Immune Tolerance During Human Pregnancy

Inflammatory Ulcers

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