Human Immunodeficiency Virus Type 1-Associated Cd4 Downmodulation

Geleziunas, Romas; Bour, Stephan; Wainberg, Mark A.

doi:10.1016/s0065-3527(08)60330-9

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Cited by 7 publications

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References 328 publications

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“…In addition to being a component of burgeoning viruses, the envelope is also believed to bind to the cellular receptor of the virus, either intracellularly or at the cell membrane. This interaction prevents adequate surface display of the receptor, without which other retroviruses dependent on the same receptor cannot enter and infect the cell [8-10]. …”

Section: Introductionmentioning

confidence: 99%

A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

et al. 2004

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Section: Introductionmentioning

confidence: 99%

A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

et al. 2004

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The extracellular domain of immunodeficiency virus gp41 protein: Expression inEscherichia coli, purification, and crystallization

et al. 1997

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The env gene of SIV and HIV-I encodes a single glycoprotein gp160, which is processed to give a noncovalent complex of the soluble glycoprotein gp120 and the transmembrane glycoprotein gp41. The extracellular region (ectodomain), minus the N-terminal fusion peptide, of gp41 from HIV-1 (residues 27-154) and SIV (residues 27-149) have been expressed in Escherichia coli. These insoluble proteins were solubilized and subjected to a simple purification and folding scheme, which results in high yields of soluble protein. Purified proteins have a trimeric subunit composition and high a-helical content, consistent with the predicted coil-coil structure. SIV gp41 containing a double cysteine mutation was crystallized. The crystals are suitable for X-ray structure determination and, preliminary analysis, together with additional biochemical evidence, indicates that the gp41 trimer is arranged as a parallel bundle with threefold symmetry.

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Multiple Stages of Virus-Receptor Interactions as Shown by Simian Virus 40

Norkin

Anderson

1996

Toward Anti-Adhesion Therapy for Microbial Diseases

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Human Immunodeficiency Virus Type 1-Associated Cd4 Downmodulation

Cited by 7 publications

References 328 publications

A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

A murine leukemia virus with Cre-LoxP excisible coding sequences allowing superinfection, transgene delivery, and generation of host genomic deletions

The extracellular domain of immunodeficiency virus gp41 protein: Expression inEscherichia coli, purification, and crystallization

Multiple Stages of Virus-Receptor Interactions as Shown by Simian Virus 40

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