Human immunodeficiency virus type 1 Vif binds the viral protease by interaction with its N-terminal region

Baraz, Lea; Hutoran, Marina; Blumenzweig, Immanuel; Katzenellenbogen, Mark; Friedler, Assaf; Gilon, Chaim; Kotler, Moshe

doi:10.1099/0022-1317-83-9-2225

Cited by 13 publications

(11 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…69 Other studies involved the Vif and protease proteins of HIV-1 that have been shown to interact with each other. 70 A peptide derived from the N-terminus of protease seems to block that interaction and consequently inhibit HIV-1 replication in restrictive cells. 71 It yet has to be seen if these peptides and similar will have antagonistic effects when expressed inside the cell.…”

Section: Prospectsmentioning

confidence: 99%

Gene therapy progress and prospects: Novel gene therapy approaches for AIDS

Wolkowicz

Nolan

2005

Gene Ther

View full text Add to dashboard Cite

Section: Prospectsmentioning

confidence: 99%

Gene therapy progress and prospects: Novel gene therapy approaches for AIDS

Wolkowicz

Nolan

2005

Gene Ther

View full text Add to dashboard Cite

“…Accumulated evidence suggests that Vif selectively inhibits protease-mediated proteolytic processing at specific cleavage sites (e.g., matrix Խ capsid [518] and SP1 Խ NC [307]). Although it remains debated, the Vif-protease interaction is speculated to inhibit the protease digestion of cellular cofactors (516,519).…”

Section: Protease-vif Interactionmentioning

confidence: 99%

“…Regarding the interaction domains, the N-terminal domain of protease (positions 1 to 9 [516,517]) may interact with the central domain of Vif (positions 78 to 98 [516,519]). Of interest, Vifderived peptides (positions 21 to 65 [520], 30 to 65 [519], 81 to 88 [521], 78 to 98 [519], and 88 to 98 [521]) may efficiently inhibit HIV-1 protease activity.…”

Section: Protease-vif Interactionmentioning

confidence: 99%

“…Findings from coimmunoprecipitation assays, ELISAs, and HIV-1 binding assays suggest that HIV-1 Vif physically interacts with protease (282,516,517). To inhibit the premature activation of viral protease, HIV-1 Vif interacts with protease to interfere with protease dimerization (516)(517)(518).…”

Section: Protease-vif Interactionmentioning

confidence: 99%

“…To inhibit the premature activation of viral protease, HIV-1 Vif interacts with protease to interfere with protease dimerization (516)(517)(518). The binding of Vif to protease might take place inside HIV-1-infected cells prior to viral budding, potentially interrupting the autoprocessing of Gag and GagPol precursors (518).…”

Section: Protease-vif Interactionmentioning

confidence: 99%

See 2 more Smart Citations

HIV Genome-Wide Protein Associations: a Review of 30 Years of Research

Clercq

2016

Microbiol Mol Biol Rev

View full text Add to dashboard Cite

SUMMARYThe HIV genome encodes a small number of viral proteins (i.e., 16), invariably establishing cooperative associations among HIV proteins and between HIV and host proteins, to invade host cells and hijack their internal machineries. As a known example, the HIV envelope glycoprotein GP120 is closely associated with GP41 for viral entry. From a genome-wide perspective, a hypothesis can be worked out to determine whether 16 HIV proteins could develop 120 possible pairwise associations either by physical interactions or by functional associations mediated via HIV or host molecules. Here, we present the first systematic review of experimental evidence on HIV genome-wide protein associations using a large body of publications accumulated over the past 3 decades. Of 120 possible pairwise associations between 16 HIV proteins, at least 34 physical interactions and 17 functional associations have been identified. To achieve efficient viral replication and infection, HIV protein associations play essential roles (e.g., cleavage, inhibition, and activation) during the HIV life cycle. In either a dispensable or an indispensable manner, each HIV protein collaborates with another viral protein to accomplish specific activities that precisely take place at the proper stages of the HIV life cycle. In addition, HIV genome-wide protein associations have an impact on anti-HIV inhibitors due to the extensive cross talk between drug-inhibited proteins and other HIV proteins. Overall, this study presents for the first time a comprehensive overview of HIV genome-wide protein associations, highlighting meticulous collaborations between all viral proteins during the HIV life cycle.

show abstract