Human immunodeficiency virus–positive patient with bilateral corneal endothelial deposits

Corneal deposits secondary to rifabutin

“…This revealed nine publications with reports of 43 patients with rifabutin‐attributed corneal deposits. To our knowledge, the entirety of the reports in this patient population noted bilateral yellow‐white/yellow‐brown coloured, stellate deposits concentrated predominantly in the peripheral cornea (Table ). Located in the posterior layers of the cornea, they tend to affect the periphery first and later appear centrally.…”

“…Ultimately, sustained benefit of treatment with antibiotics was not demonstrated, lending evidence against a mycobacterial aetiology for Crohn's disease. Interestingly, corneal deposits had the potential to develop in this subset of patients on rifabutin . These deposits proved to be irreversible even years after cessation and may increase in pigmentation and density .…”

“…The aetiology of these corneal deposits is not fully understood; however, the high lipid solubility and high protein‐binding property of this medication may contribute to the development of corneal deposits . Several local corneal endothelial factors, such as lipid solubility, pH, ionic interaction and protein‐binding affinity may play a role in the circumferential peripheral pattern of these deposits . Several studies have been done relating to the histology of these deposits.…”

Transient Anterior Corneal Deposits in a Human Immunodeficiency Virus-Positive Patient

“…4 In all cases, however, rifabutinassociated corneal deposits were localized to the endothelium, Descemet's membrane, or the posterior stroma, and were present predominantly in the peripheral cornea. Additionally, an increase in density and size of rifabutin-associated corneal deposits over time has been noted by some investigators, 8,9 while others have noted a static behaviour.…”

“…Deposits in these cases have varied in pigmentation from light brown 4 to yellow-brown or golden 4,8,10 to yellow-white, 9 white, 11 or gray-white. 4 In all cases, however, rifabutinassociated corneal deposits were localized to the endothelium, Descemet's membrane, or the posterior stroma, and were present predominantly in the peripheral cornea.…”