Human Immunodeficiency Virus Infection Search for Musculoskeletal Manifestations and Mimicking of Rheumatologic Disorders

Mg, Rosemffet; La, Padulo; Stockhamer, D; C, Piovano; Sd, Representacao; Ma, Meregalli; Ja, Maldonado Cocco

doi:10.1097/00124743-199606000-00003

Cited by 2 publications

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“…Zhang et al identified CD4 lymphocyte depletion as an independent risk factor for the development of rheumatic disorders among HIV-positive patients in China, 37 while Rosemffet et al reported that more severely immunocompromised patients were more likely to have musculoskeletal symptoms. 38 In Enugu, Southeast Nigeria, Okwara et al observed that CD4 count was predictive of HIV-associated arthritis. 39 Umar et al in Zaria also reported an association between levels of CD4 counts, WHO clinical staging of HIV, and rheumatic diseases.…”

Section: Discussionmentioning

confidence: 99%

“…This supports the findings of several studies in different parts of the world. Zhang et al identified CD4 lymphocyte depletion as an independent risk factor for the development of rheumatic disorders among HIV‐positive patients in China, 37 while Rosemffet et al reported that more severely immunocompromised patients were more likely to have musculoskeletal symptoms 38 . In Enugu, Southeast Nigeria, Okwara et al observed that CD4 count was predictive of HIV‐associated arthritis 39 .…”

Section: Discussionmentioning

confidence: 99%

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Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

et al. 2021

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Background Fibromyalgia is a chronic pain syndrome of unknown etiology characterized by chronic widespread musculoskeletal pain and tenderness. It affects the quality of life of patients and has been associated with the human immunodeficiency virus (HIV). The study aimed to determine the prevalence of fibromyalgia in HIV‐positive patients and assess the effect of fibromyalgia on their functional status. Methodology This was a cross‐sectional study comprising 160 treatment‐naive HIV‐positive patients and 160 age‐ and sex‐matched HIV‐negative controls. The diagnosis of fibromyalgia was based on the 2011 modification of the 2010 American College of Rheumatology diagnostic criteria by assessing the widespread pain index and symptom severity score. The severity of fibromyalgia was assessed with the revised fibromyalgia impact questionnaire. Results The prevalence of fibromyalgia in HIV‐positive individuals was found to be 10.6%, which was significantly higher compared with controls (3.1%; P = .008). There was no significant association between fibromyalgia and age, gender, or occupation. There was a significant relationship between CD4 count levels (P < .001), WHO clinical stage (P < .001), and fibromyalgia. A statistically significant higher score on the Revised FM Impact Questionnaire was found in HIV‐positive individuals with fibromyalgia (P < .001). Conclusion The study found that HIV‐positive patients had a significantly higher incidence of fibromyalgia than controls and this was related to active indices of HIV disease. Fibromyalgia had a greater clinical impact on HIV patients than in controls. As a result, fibromyalgia should be identified and treated in people living with HIV.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

et al. 2021

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Rheumatic Syndromes Associated with HIV Infection

Bateman¹,

Centeno²,

Bielory³

1997

BioDrugs

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The association of HIV infection with rheumatic syndromes is reviewed, with emphasis on the specific differences between the rheumatic diseases in their idiopathic form compared with their occurrence with HIV infection. Alterations in presentation, pathogenesis and treatment are stressed. The first section of the article concentrates on joint and articular involvement, and the second on autoimmune phenomenon in relation to lymphatic organs, muscle and vasculature. Wherever possible, the direct effect of the HIV organism or its effect on the immune system modifying or contributing to the aetiology of each disease is discussed. HIV infection has many manifestations, and involvement of the musculoskeletal system is not uncommon. Various infections of bone, joint and muscle have been described, which is not surprising considering the immunodeficiency associated with HIV. Reiter's syndrome and the seronegative arthropathies and reactive arthritides also may be expected, particularly with the possible occurrence with sexually transmitted organisms. New onset of psoriasis in an adult should prompt the physician to consider HIV infection in the differential diagnosis. Perhaps more surprising is the occurrence of autoimmune diseases in association with HIV. However, as will be described, some of the associations such as rheumatoid arthritis and HIV are controversial and we attempt to describe current theories on pathogenesis, recognising that much more investigation is needed before we have a complete understanding of this disease.

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Human Immunodeficiency Virus Infection Search for Musculoskeletal Manifestations and Mimicking of Rheumatologic Disorders

Cited by 2 publications

References 0 publications

Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

Fibromyalgia in HIV‐positive patients in Nigeria: A cross‐sectional prospective study

Rheumatic Syndromes Associated with HIV Infection

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