Human immunodeficiency virus infection in vitro activates naturally integrated human papillomavirus type 18 and induces synthesis of the L1 capsid protein

Dolei, Antonina; Curreli, Sabrina; Marongiu, P.; Pierangeli, Alessandra; Gomes, Eduarda; Bucci, Mauro; Serra, Caterina; Degener, Anna Marta

doi:10.1099/0022-1317-80-11-2937

Cited by 45 publications

(42 citation statements)

References 50 publications

(107 reference statements)

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“…Because HPV does not disseminate and is known to be controlled locally by CMI responses, it seems likely that suppression of the immune response (particularly reduced CD4 cell activity following infection with HIV) would worsen the natural course of an HPV infection. There is evidence, however, that HIV infection changes the transcription pattern of HPV L1, E1, E2, and E7 genes (45)(46)(47). The relationship between these viruses may also be reciprocal with both a mutual alteration of gene expression occurring and a mutual increase in transmissibility as a result of local immune dysregulation or compromise of mucosal integrity (48).…”

Section: Impact Of Hiv Co-infection On Hpv Immunitymentioning

confidence: 99%

Human Papillomavirus (HPV) Infection in Southern Africa: Prevalence, Immunity, and Vaccine Prospects

et al. 2002

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SummaryHuman papillomavirus (HPV) associated cancers are more prevalent in developing countries compared to developed countries. The major cancer caused by HPV is cervical cancer. The humoral immune response to HPV can be a marker of past infection but may also reflect persistent infection and cervical disease. IgA antibodies to HPV in oral fluid were also found to be markers of cervical disease. Cell mediated immunity is important in clearing HPV infection and for regression of the associated lesions: this means that women infected with HIV have a high prevalence of co-infection with HPV. Good cervical screening programmes can control HPV associated cervical neoplasia. However, in countries such as South Africa, where these programmes are inadequate, there is a need for an HPV vaccine. The development of HPV vaccines is reviewed. There is a call for an inexpensive vaccine that will be accessible to the women that do not have access to adequate screening programmes and are therefore at the greatest risk of cervical cancer. IUBMB Life, 53: 253-258, 2002

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Section: Impact Of Hiv Co-infection On Hpv Immunitymentioning

confidence: 99%

Human Papillomavirus (HPV) Infection in Southern Africa: Prevalence, Immunity, and Vaccine Prospects

et al. 2002

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“…Whereas old data support the observation that impaired expression may play a role in the progression of the malignant process, the role of adhesion molecules in cervical cancer was recently up-dated (Bethwaite, 1996;Bell, 1995;Dolei, 1999;Monnier-Benoit, 2006;Scott, 2001;.…”

Section: Chemokines and Adhesion Moleculesmentioning

confidence: 99%

“…Since T helper lymphocytes have important roles in aiding the development of cytotoxic lymphocytes, a possible association between these cells and clearance of virus may not be accurate reflections of a correlation between T helper cells responses and the HPV infection (Arany, 1995;Bethwaite, 1996;Dolei, 1999;Goncalves & Donadi, 2004;Nakagawa, 2000;Scott, 2001). …”

Section: T-cell Responses To Hpv Infectionmentioning

confidence: 99%

“…For example, the lowest IL-2 levels were demonstrated in women with cervical cancer, while the highest levels of IL-2 were reported in cytologically normal HPV women. Besides, there is strong evidence that MHC class I and/or MHC class II molecules downregulation may decrease immune recognition of HPV-associated tumors through modulating IL-10 production (Bethwaite, 1996;Dolei, 1999;Goncalves & Donadi, 2004;Monnier-Benoit, 2006;.…”

Section: Cytokines Regulating T-cell Responsesmentioning

confidence: 99%

“…Three potential mechanisms for HPV immune-surveillance were actually proposed, including:  E7 protein may inhibit local immune response by blocking the antigen presenting function of dendritic cells from the epithelium in cervical tissue;  an effective immune response against the HPV infected cells in the basal epithelium, where the E6 and E7 early genes are expressed; capsid encoding genes delayed expression may be the consequence of the inhibition promoted by a codon usage still remain exploratory, but this scenario is still exploratory;  lack of CTL response to the HPV infected cells: keratinocytes may be less susceptible to class I mediated lysis by alloantigen-primed CTL (Bethwaite, 1996;Dolei, 1999;Goncalves & Donadi, 2004;Palefsky, 1999;Scott, 2001; …”

Section: Clearance Of Hpv Infection and Clinical Implicationsmentioning

confidence: 99%

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Predictive Value of Cellular Immune Response and Tumor Biomarkers in Patients Surgically Treated for Cervical Cancer in Relation to Clinical Outcomes"

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Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

Merz

Afriyie

Jiagge

et al. 2019

Health Science Reports

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Background and aims Conjunctival squamous cell carcinoma (CSCC) varies in incidence geographically from 0 to 1 case per 100 000 per year globally. Additionally, the incidence of CSCC is known to increase 49% for every 10° decrease in latitude. Since the onset of the AIDS epidemic, there has been a trend of increasing incidence of CSCC in Africa, and despite relatively stable levels of ultraviolet (UV) exposure, there is an observed 12 times greater risk of developing CSCC when individuals are infected with HIV. In this study, we aim to analyze the clinical characteristics and biomarkers of CSCC in Ghana. Methods In this study, a registry review of patients from January 2011 to May 2016 with CSCC at Komfo‐Anokye Teaching Hospital in Kumasi, Ghana, was performed (n = 64). Tumor blocks of the CSCC were analyzed for the expression of various biomarkers. Results In this study, the median age of onset of CSCC is 46.5 years old (range of 20–90 y old). Fifty one and a half percent (n = 33) of the cohort is female. There is a low rate of smoking and alcohol use in our CSCC cohort. Thirty‐nine percent (n = 12) of Ghanaian men with CSCC are HIV−, while only 12% (n = 4) of women are HIV−. Fifteen patients had metastasis to lymph nodes or other tissues, and we observed a statistically significant relationship between HIV infection and metastasis (P = 0.027, chi‐squared test). We observed no statistically significant relationship between known prognostic CSCC biomarkers and HIV status, age, or tumor stage. Conclusion Better characterization of CSCC could have a profound impact on the prevention, early identification, and treatment of CSCC in Africa. A retrospective chart analysis and collection of tumor samples can be challenging in this region due to methods of record keeping and stigma attached to clinical data such as HIV testing and smoking and alcohol use. As a result, in this study, data were often incomplete leading to inconclusive results and analysis that should be interpreted with caution. Future studies should consider a prospective study design that gathers clinical data in a standardized format and ensures fresh tissue from CSCC tumors.

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Human immunodeficiency virus infection in vitro activates naturally integrated human papillomavirus type 18 and induces synthesis of the L1 capsid protein

Cited by 45 publications

References 50 publications

Human Papillomavirus (HPV) Infection in Southern Africa: Prevalence, Immunity, and Vaccine Prospects

Human Papillomavirus (HPV) Infection in Southern Africa: Prevalence, Immunity, and Vaccine Prospects

Predictive Value of Cellular Immune Response and Tumor Biomarkers in Patients Surgically Treated for Cervical Cancer in Relation to Clinical Outcomes"

Clinical characteristics, HIV status, and molecular biomarkers in squamous cell carcinoma of the conjunctiva in Ghana

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