Human immunodeficiency virus infection in patients with leukemia

Minamoto, GY; Scheinberg, D. A.; Dietz, K; Gold, JW; Chein, Nancy; Gee, Timothy; Reich, Lillian; Hoffer, J; Mayer, Klaus; Armstrong, Deborah K.

doi:10.1182/blood.v71.4.1147.bloodjournal7141147

Cited by 2 publications

(4 citation statements)

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“…In paediatric oncology patients in Ohio, 100% consented to HIV testing. 8 In two Canadian paediatric cohorts the acceptance rates for HIV testing were 100% and 96% respectively. 18±19 However, based on focus groups, it was expected that asking patients to allow their HIV test results to be sent to anyone other than the ordering physician would reduce the acceptance of HIV testing.…”

Section: Discussionmentioning

confidence: 99%

“…Acceptance rates for HIV testing have been very high in paediatric transfusion cohorts. In paediatric oncology patients in Ohio, 100% consented to HIV testing 8 . In two Canadian paediatric cohorts the acceptance rates for HIV testing were 100% and 96% respectively 18 –19 .…”

Section: Discussionmentioning

confidence: 99%

“…Most of the estimates of incidence of HIV infection in transfusion recipients before routine donor testing for HIV‐1 antibody were based on modelling techniques in which a variety of assumptions were made and which provided disparate results 2 –7 . The prevalence of HIV infection has been reported in small cohorts of patients who were multiply transfused 8 –11 . The generalisability of these results is limited.…”

Section: Introductionmentioning

confidence: 99%

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Safety of the Canadian blood supply in 1980–85: using a paediatric cohort for risk assessment of human immunodeficiency virus (HIV) infection

T¹,

Corey²,

Major³

et al. 2001

Paediatric Perinatal Epid

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The risk of HIV from transfusions in Canada in the period 1980-85 was estimated, using the information from a transfused paediatric cohort. Children who were transfused between January 1980 and November 1985 at a tertiary care paediatric hospital were contacted by letter. With this notification, HIV testing for recipients was recommended. HIV testing histories were obtained. The number tested for HIV was estimated from the questionnaire responses and from data matching with the HIV-testing laboratory. Cases of HIV infection were identified through multiple sources. In this cohort, 11,028 children were transfused a mean of 21 units. Of the 10,220 living recipients, the estimated proportion tested for HIV was 86% to 91%. Thirty-one cases of HIV infection were identified, representing 0.28% of the cohort but 0.34% of those expected to have been tested. The estimated HIV incidence per 1,000 units transfused ranged from 0.028 [95% CI 0.0007, 0.155] in 1980 to 0.445 [95% CI 0.2592, 0.712] in 1985. This suggests that the risk of HIV from transfusions in Canada continued to rise until the implementation of HIV testing of donors in November 1985.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Safety of the Canadian blood supply in 1980–85: using a paediatric cohort for risk assessment of human immunodeficiency virus (HIV) infection

T¹,

Corey²,

Major³

et al. 2001

Paediatric Perinatal Epid

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“…The patient despite his retroviral infection had been treated like any other ANLL patient and had encountered a similar outcome. It would appear that HIV seropositivity is not necessarily a contraindication to aggressive Accepted for publication: 6 June 1990…”

Section: Discussionmentioning

confidence: 99%

First and second complete remissions in a HIV positive patient following remission induction therapy for acute non‐lymphoblastic leukaemia

Mansberg

Rowlings

Yip

et al. 1991

Australian and New Zealand Journal of Medicine

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A small number of patients positive for the human immunodeficiency virus (HIV) have been reported as developing acute non-Iymphoblastic leukaemia (ANLL) and none has achieved remission despite attempts at treatment.We report on a 34-year-old HIV positive heterosexual intravenous drug user who presented with ANLL (FAB classification M5, Monoblastic) and entered remission following one cycle of cytosine arabinoside and daunorubicin according to the 7-3 protocol of the Australian Leukaemia Study Group (ALSG). This was followed by consolidation of 5-2 as per ALSG and one cycle of maintenance with low dose cytosine arabinoside. Ten months after remission, he relapsed but achieved a second remission with the ALSG 7-3-7 protocol (7-3 plus etoposide) followed by consolidation with 5-2-5. He remained HIV positive b u t showed little progression towards the acquired immunodeficiency syndrome despite the intense immunosuppression. The duration of his second remission was five months. The patient died of septicaemia during the third attempt at remission induction 18 months after diagnosis.We conclude that HIV seropositivity is not an absolute contraindication to aggressive chemotherapy in those patients who develop ANLL. (Aust NZ J Med 1991; 21: 55-57.)

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Human immunodeficiency virus infection in patients with leukemia

Cited by 2 publications

References 0 publications

Safety of the Canadian blood supply in 1980–85: using a paediatric cohort for risk assessment of human immunodeficiency virus (HIV) infection

Safety of the Canadian blood supply in 1980–85: using a paediatric cohort for risk assessment of human immunodeficiency virus (HIV) infection

First and second complete remissions in a HIV positive patient following remission induction therapy for acute non‐lymphoblastic leukaemia

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