Human immunodeficiency virus infection (HIV)–associated rheumatic manifestations in thepre- and post-HAART eras

Vega, Luis E.; Espinoza, Luis R.

doi:10.1007/s10067-020-05082-8

Cited by 19 publications

(13 citation statements)

References 65 publications

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“…Vaccines, as a prophylactic approach, are the primary strategy for controlling viral outbreaks and even successfully contributing to total eradication of the agent responsible [ 106 ]. However, post-infection treatments are also needed, mostly due to the high pathogenicity that current pandemic-responsible virus displays, as stated previously [ 20 , 21 , 22 , 23 ]. The urgency for new and innovative antiviral therapeutics is also reinforced by the quick mutation rate of viral strains, which often leads to the creation of unique and drug-resistant viruses [ 107 ].…”

Section: Screening Methodologies For the Detection Of Bioactive Mamentioning

confidence: 99%

“…This last mentioned epidemic, like SARS-CoV-2, affected China, causing 774 deaths and 100 billion dollars in losses [ 22 ]. Moreover, humanity is still struggling with past pandemics, such as the HIV/AIDS pandemic, which still infects 37 million people around the world [ 23 ]. Furthermore, as novel viral diseases keep appearing, and antivirals are usually specifically targeted, research of new therapeutics is continuously needed [ 24 ].…”

Section: Health Challenges Faced Todaymentioning

confidence: 99%

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From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria

et al. 2020

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Oceans cover seventy percent of the planet’s surface and besides being an immense reservoir of biological life, they serve as vital sources for human sustenance, tourism, transport and commerce. Yet, it is estimated by the National Oceanic and Atmospheric Administration (NOAA) that eighty percent of the oceans remain unexplored. The untapped biological resources present in oceans may be fundamental in solving several of the world’s public health crises of the 21st century, which span from the rise of antibiotic resistance in bacteria, pathogenic fungi and parasites, to the rise of cancer incidence and viral infection outbreaks. In this review, health risks as well as how marine bacterial derived natural products may be tools to fight them will be discussed. Moreover, an overview will be made of the research pipeline of novel molecules, from identification of bioactive bacterial crude extracts to the isolation and chemical characterization of the molecules within the framework of the One Health approach. This review highlights information that has been published since 2014, showing the current relevance of marine bacteria for the discovery of novel natural products.

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Section: Screening Methodologies For the Detection Of Bioactive Mamentioning

confidence: 99%

Section: Health Challenges Faced Todaymentioning

confidence: 99%

From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria

et al. 2020

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“…In the era after the advent of the highly active antiretroviral therapy, although the incidence and prevalence of rheumatic manifestations associated to HIV infection have significantly declined, other rheumatic disorders have emerged in HIV infected patients, namely systemic and discoid lupus erythematosus, polymyositis, Behçet's disease, autoimmune hemolytic anemia, adult-onset Still's disease, osteoporosis, and avascular bone necrosis [15].…”

Section: Which Are the Rheumatic Manifestations In Hiv-infected Individuals?mentioning

confidence: 99%

Rheumatic Manifestations: A Compilation

Moutsopoulos¹,

Zampeli

2020

Immunology and Rheumatology in Questions

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Autoimmune diseases present with a wide range of symptoms able to affect nearly all body organs. Differential diagnosis of these symptoms can be difficult, as a particular presenting symptom may be encountered in distinct autoimmune diseases, and at the same time many non-rheumatic diseases may share similar clinical manifestations. In the large overlapping field of infections and rheumatology, many autoimmune diseases may present as fever of unknown origin, and on the other hand, many different infectious agents cause signs and symptoms mimicking a systemic autoimmune disease. Clinical manifestations affecting the skin and its annexes, oral cavity, joints, and periarticular structures but also major organs such as the heart and vascular system, lung, liver, spleen, and gastrointestinal tract can be initial symptoms of a systemic autoimmune disease. The use of immune checkpoint inhibitors for the treatment of different types of cancers has radically changed

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“…Additionally, humankind is currently still battling a past pandemic caused by the human immunodeficiency virus. The acquired immunodeficiency syndrome (HIV/AIDS) outbreak has infected 37 million individuals globally [15].…”

Section: Introductionmentioning

confidence: 99%

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

et al. 2021

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The prevalence of antimicrobial resistance reduces the effectiveness of antimicrobial drugs in preventing and treating infectious diseases caused by pathogenic organisms, such as bacteria, fungi, and viruses. Because of the burgeoning growth of microbes with antimicrobial-resistant traits, there is a dire need to identify and develop novel and effective antimicrobial agents to treat infections from antimicrobial-resistant strains. The marine environment is rich in ecological biodiversity and can be regarded as an untapped resource for prospecting novel bioactive compounds. Therefore, exploring the marine environment for antimicrobial agents plays a significant role in drug development and biomedical research. Several earlier scientific investigations have proven that bacterial diversity in the marine environment represents an emerging source of structurally unique and novel antimicrobial agents. There are several reports on marine bacterial secondary metabolites, and many are pharmacologically significant and have enormous promise for developing effective antimicrobial drugs to combat microbial infections in drug-resistant pathogens. In this review, we attempt to summarize published articles from the last twenty-five years (1996–2020) on antimicrobial secondary metabolites from marine bacteria evolved in marine environments, such as marine sediment, water, fauna, and flora.

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Human immunodeficiency virus infection (HIV)–associated rheumatic manifestations in thepre- and post-HAART eras

Cited by 19 publications

References 65 publications

From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria

From Ocean to Medicine: Pharmaceutical Applications of Metabolites from Marine Bacteria

Rheumatic Manifestations: A Compilation

Marine Bacterial Secondary Metabolites: A Treasure House for Structurally Unique and Effective Antimicrobial Compounds

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