Human immunodeficiency virus infection and its association with sarcopenia

Neto, Lauro Ferreira da Silva Pinto; Sales, Marina Cerqueira; Scaramussa, Eduarda Sobral; Paz, Clara Junia Calazans da; Morelato, Renato Lírio

doi:10.1016/j.bjid.2015.10.003

Cited by 36 publications

(35 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To our knowledge, the negative impact of these 2 morbidities has not previously been reported in the literature. In the most recent series about HIV patients, sarcopenia was often described according to the European consensus with muscle mass being calculated as appendicular skeletal muscle mass/height 2 . This definition is not specific to HIV status, and the cutoffs were not calculated in this specific population.…”

Section: Discussionmentioning

confidence: 99%

A new definition of sarcopenia in patients with cirrhosis undergoing liver transplantation

et al. 2017

View full text Add to dashboard Cite

Although sarcopenia is a common complication of cirrhosis, its diagnosis remains nonconsensual: computed tomography (CT) scan determinations vary and no cutoff values have been established in cirrhotic populations undergoing liver transplantation (LT). Our aim was to compare the accuracy of the most widely used measurement techniques and to establish useful cutoffs in the setting of LT. From the 440 patients transplanted between January 2008 and May 2011 in our tertiary center, we selected 256 patients with cirrhosis for whom a recent CT scan was available during the 4 months prior to LT. We measured different muscle indexes: psoas muscle area (PMA), PMA normalized by height or body surface area (BSA), and the third lumbar vertebra skeletal muscle index (L3SMI). Receiver operating characteristic curves were evaluated and prognostic factors for post-LT 1-year survival were then analyzed. PMA offered better accuracy (area under the curve [AUC] = 0.753) than L3SMI (AUC = 0.707) and PMA/BSA (AUC = 0.732), and the same accuracy as PMA/squared height. So, for its accuracy and simplicity of use, the PMA index was used for the remainder of the analysis and to define sarcopenia. In men, the better cutoff value for PMA was 1561 mm (Se = 94%, Sp = 57%), whereas in women, it was 1464 mm (Se = 52%, Sp = 91%). A PMA lower than these values defined sarcopenia in patients with cirrhosis awaiting LT. One- and 5-year overall survival rates were significantly poorer in the sarcopenic group (n = 57) than in the nonsarcopenic group (n = 199), at 59% versus 94% and 54% versus 80%, respectively (P < 0.001). In conclusion, pre-LT PMA is a simple tool to assess sarcopenia. We established sex-specific cutoff values (1561 mm in men, 1464 mm in women) in a cirrhotic population and showed that 1-year survival was significantly poorer in sarcopenic patients. Liver Transplantation 23 143-154 2017 AASLD.

show abstract

Section: Discussionmentioning

confidence: 99%

A new definition of sarcopenia in patients with cirrhosis undergoing liver transplantation

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Based on two reports, the prevalence of sarcopenia among HIV‐infected patients was calculated (applying the EWGSOP criteria) to be 5.0% ( n = 80, mean age 54 years) and 24.2% ( n = 33, mean age 59 years) …”

Section: ▸[B] Epidemiology Of Related Disease Statesmentioning

confidence: 99%

Chapter 2 Epidemiology of sarcopenia

Shimokata

Shimada

Satake

et al. 2018

Geriatrics Gerontology Int

View full text Add to dashboard Cite

“…The exact mechanisms underlying these relationships are incompletely understood, but may be related to adipocytokine imbalances[95] and/or chronic inflammation and immune activation[96, 97]. Complicating this fact is the observation of faster rates of functional decline and high rates of sarcopenia among HIV-infected vs HIV-uninfected persons[98–101, 15], although sex differences may exist. As the obesity and aging epidemics in HIV-infected persons collide, understanding the mechanisms by which obesity and visceral adiposity contribute to functional decline will play an important role in maximizing physical function and preventing further decline in this population.…”

Section: Consequences Of Obesity and Visceral Adipositymentioning

confidence: 99%

The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

Lake

2017

Curr HIV/AIDS Rep

View full text Add to dashboard Cite

Purpose of Review To summarize knowledge of the prevalence, relevant physiology and consequences of obesity and visceral adiposity in HIV-infected adults, including highlighting gaps in current knowledge and future research directions. Recent Findings Similar to the general population, obesity prevalence is increasing among HIV-infected persons, and obesity and visceral adiposity are associated with numerous metabolic and inflammatory sequelae. However, HIV- and antiretroviral therapy (ART)-specific factors may contribute to fat gain and fat quality in treated HIV infection, particularly to the development of visceral adiposity, and sex differences may exist. Summary Obesity and visceral adiposity commonly occur in HIV-infected persons and have significant implications for morbidity and mortality. Future research should aim to better elucidate the HIV- and ART-specific contributors to obesity and visceral adiposity in treated HIV infection, with the goal of developing targeted therapies for the prevention and treatment of obesity and visceral adiposity in the modern ART era.

show abstract

Human immunodeficiency virus infection and its association with sarcopenia

Cited by 36 publications

References 18 publications

A new definition of sarcopenia in patients with cirrhosis undergoing liver transplantation

A new definition of sarcopenia in patients with cirrhosis undergoing liver transplantation

Chapter 2 Epidemiology of sarcopenia

The Fat of the Matter: Obesity and Visceral Adiposity in Treated HIV Infection

Contact Info

Product

Resources

About