Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men

Verboeket, Sebastiaan O; Wit, Ferdinand W. N. M.; Verheij, Eveline; Zoest, Rosan A van; Kootstra, Neeltje A.; Valk, Marc van der; Prins, Jan M.; Loeff, Maarten F. Schim van der; Reiss, Peter

doi:10.1093/infdis/jiaa048

Cited by 9 publications

(7 citation statements)

References 45 publications

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“…Another plausible contributor to the CD8 T-lymphocyte count differences we observed is that syphilis may be a proxy for other unmeasured concomitant STIs which are more directly linked to elevation of CD8 T-lymphocyte level. For instance, MSM showed higher CD8 T-lymphocyte levels and lower CD4/CD8 ratios than men who only have sex with women in a study of 368 HIV-negative participants, in which the differences could be partially explained by the higher CMV seroprevalence among MSM [37].…”

Section: Discussionmentioning

confidence: 99%

Clinical and laboratory impact of concomitant syphilis infection during acute HIV

et al. 2021

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Cognitive impairment has been reported in people living with HIV-1 (PLWH) with prior syphilis, while PLWH who present with incident syphilis have reduced blood CD4 T-lymphocyte and elevated HIV-1 RNA levels. However, the clinical, virological and neurocognitive effects of syphilis during acute HIV-1 (AHI) remain unknown. MethodsPre-antiretroviral therapy laboratory outcomes and neurocognitive performance in a four-test battery in the SEARCH10/RV254 AHI cohort were compared according to syphilis status, determined by serum Treponema pallidum haemagglutination (TPHA), Venereal Disease Research Laboratory (VDRL) and syphilis treatment history. Impaired cognitive performance was defined as having z-scores ≤ À1 in at least two tests or ≤ À2 in at least one test. ResultsOut of 595 AHI participants (97% male, median age of 26 years and estimated duration of HIV-1 infection of 19 days), 119 (20%) had history of syphilis (TPHA-positive), of whom 51 (9%) had untreated syphilis (TPHA-positive/VDRL-positive/without prior treatment). Compared with those without syphilis (TPHA-negative), individuals with untreated syphilis had higher CD8 Tlymphocyte levels but not higher plasma HIV-1 RNA or lower CD4 T-lymphocyte levels. Taking into account estimated duration of HIV-1 infection (P < 0.001), and later Fiebig stages (III-V) (P < 0.001), those with untreated syphilis had higher CD8 T-lymphocyte levels (P = 0.049). Individuals with any syphilis (TPHA-positive), but not untreated syphilis, had higher odds of impaired cognitive performance than those without (P = 0.002). ConclusionsDuring AHI, individuals with any history of syphilis (TPHA-positive) had poorer cognitive performance than those without syphilis. However, syphilis was not associated with worsened HIV disease measures as described in chronic infection.

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Section: Discussionmentioning

confidence: 99%

Clinical and laboratory impact of concomitant syphilis infection during acute HIV

et al. 2021

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“…A recent study comparing MSM and heterosexual men, all of whom were HIV-negative, found MSM and MSM reporting multiple recent partners more specifically to have lower CD4/CD8 ratios on average. Cytomegalovirus (CMV) infection was hypothesized to contribute to observed differences, but drug use did not appear to be associated [ 24 ]. Unfortunately, we were not able to account for CMV infection in our analysis due to data reliability concerns.…”

Section: Discussionmentioning

confidence: 99%

Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)

et al. 2023

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Background To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell count ratio, a marker of chronic inflammation, in virally suppressed people living with HIV-1 (PLWH) in Nouvelle Aquitaine, France. Methods A multi-centric, cross-sectional analysis was conducted in 2018–19 in the QuAliV study—ANRS CO3 AQUIVIH-NA cohort. Tobacco, alcohol, cannabis, and other drug use (poppers, cocaine, amphetamines, synthetic cathinones, GHB/GBL) were self-reported. CD4 and CD8 T cell counts and viral load measures, ± 2 years of self-report, and other characteristics were abstracted from medical records. Univariable and multivariable linear regression models, adjusted for age, sex, HIV risk group, time since HIV diagnosis, and other drug use were fit for each drug and most recent CD4/CD8 ratio. Results 660 PLWH, aged 54.7 ± 11.2, were included. 47.7% [315/660] had a CD4/CD8 ratio of < 1. Their mean CD4/CD8 ratio was 1.1 ± 0.6. 35% smoked; ~ 40% were considered to be hazardous drinkers or have alcohol use disorder; 19.9% used cannabis and 11.9% other drugs. Chemsex-associated drug users’ CD4/CD8 ratio was on average 0.226 (95% confidence interval [95% CI] − 0.383, − 0.070) lower than that of non-users in univariable analysis (p = 0.005) and 0.165 lower [95% CI − 0.343, 0.012] in multivariable analysis (p = 0.068). Conclusions Mean differences in CD4/CD8 ratio were not significantly different in tobacco, alcohol and cannabis users compared to non-users. However, Chemsex-associated drug users may represent a population at risk of chronic inflammation, the specific determinants of which merit further investigation. Trial registration number: NCT03296202.

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“…These diseases have been correlated with a decrease in CD4+/CD8+ ratio and an increase in CD8+ lymphocytes (Freeman et al, 2016 ; Pope et al, 1994 ; Strindhall et al, 2013 ; Vieira et al, 2017 ). The results of various studies in this regard have been conflicting, with some associating a decrease in this ratio in HIV‐positive patients with greater morbidity and mortality (Ferguson et al, 1995 ; Verboeket et al, 2020 ; Wikby et al, 1998 )) and others reporting no correlation between the two (McBride & Striker, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of peri‐implantitis in a sample of HIV‐positive patients

Casula

Poli

Clemente

et al. 2021

Clinical & Exp Dental Res

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Objectives: This study aimed to assess the prevalence of peri-implantitis in human immunodeficiency virus (HIV)-positive patients and the presence of a possible correlation between the immunological profile and serological values, of peri-implantitis, and of possible differences between all-on-4 and single crown/bridge prostheses.Subjects and methods: This retrospective study included 58 adult HIV-positive patients (222 implants) with either all-in-4 prostheses or single crowns/bridges on at least one dental implant loaded for more than a year who were followed for 3 year (mean follow-up). Data pertaining to the probing pocket depth (PPD), bleeding on probing, and immunological and systemic profile were collected.Results: Patients with single crown/bridge implant rehabilitation showed higher prevalence of peri-implantitis (34%) than patients with all-on-4 rehabilitation (0%) (p = 0.012). Patients with all-on-4 rehabilitation were significantly older than those with single crowns/bridges (p = 0.004). Patients with peri-implantitis had implants for a significantly longer duration than those without (p = 0.001), implying that the probability of peri-implantitis increases as the age of implant increases. Conclusions:The prevalence of peri-implantitis was 26% in the HIV-positive patients population. No correlation was found between patients' immunological and serological factors and peri-implantitis. The most important risk factor for peri-implantitis and mucositis was implant age.

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Human Immunodeficiency Virus (HIV)-Negative Men Who Have Sex With Men Have Higher CD8+ T-Cell Counts and Lower CD4+/CD8+ T-Cell Ratios Compared With HIV-Negative Heterosexual Men

Cited by 9 publications

References 45 publications

Clinical and laboratory impact of concomitant syphilis infection during acute HIV

Clinical and laboratory impact of concomitant syphilis infection during acute HIV

Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)

Prevalence of peri‐implantitis in a sample of HIV‐positive patients

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