Human Immunodeficiency Virus–Associated Primary Lung Cancer in the Era of Highly Active Antiretroviral Therapy: A Multi-Institutional Collaboration

D’Jaen, Gabriela; Pantanowitz, Liron; Bower, Mark; Buskin, Susan E.; Neil, Nancy; Greco, Erin; Cooley, Timothy P.; Henry, David H.; Stem, Jonathan; Dezube, Bruce J.; Stebbing, Justin; Aboulafia, David M.

doi:10.3816/clc.2010.n.051

Cited by 70 publications

(68 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, in the most recent of studies performed later in the HAART era, these two groups appear to have comparable survival times. 40,58,74 In a recent retrospective review of 75 patients with HIV-associated lung cancer, the median survival of those with advanced cancer was 9 months and was similar to the median survival of SEER lung cancer participants. 40 The direct influence of HAART on survival remains unanswered, although encouraging findings are emerging.…”

Section: Treatment and Outcomementioning

confidence: 73%

“…14,40,[54][55][56][57][58][59][60] With the exception of two retrospective studies, squamous cell cancer is the second commonest histological type (19-36%) in HIV-lung cancer patients, comparable to the 25% squamous cell cancer reported in HIV indeterminate individuals in the SEER data set. 49,53 The predominance of adenocarcinoma among HIVinfected individuals mirrors the changes in the distribution of the histological types of lung cancer seen in the general population.…”

Section: Pathological Findingsmentioning

confidence: 82%

“…40,[52][53][54][55][56][57][58][59][60][61][62] Yet, in a recent registry linkage study, the difference in the age at diagnosis of lung cancer was relatively modest between persons with AIDS and the general population (50 vs. 54 years) after adjusting for the underlying population structures. 31 In HIV-infected patients with lung cancer, men are significantly overrepresented compared to women, with a male-female sex ratio of 5-10:1.…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…Studies from the pre-HAART era and early years of the HAART era reported shorter survival times among HIV-lung cancer patients than HIV-indeterminate or negative lung cancer patients (Table 3). 40,[52][53][54][55]59,74 In a representative analysis, only 5% of the 38 patients with AIDS and lung cancer in the 1980s survived 24 months; whereas, 10% of 97 such persons survived 24 months in 1996 through 2000. 75 By comparison, 31% of lung cancer patients without AIDS survived 24 months.…”

Section: Treatment and Outcomementioning

confidence: 99%

See 3 more Smart Citations

Lung Cancer in HIV Infection

Mani

Aboulafia

2014

Cancers in People With HIV and AIDS

Self Cite

View full text Add to dashboard Cite

Lung cancer is the most prevalent non-AIDS-defining malignancy in the HAART era. Smoking plays a significant role in the development of HIV-associated lung cancer, but the cancer risk is 2-4 times greater in HIV-infected persons than in the general population, even after adjusting for smoking intensity and duration. Lung cancer is typically diagnosed a decade or more earlier among HIV-infected persons (mean age, 46 years) compared to those without HIV infection. Adenocarcinoma is the commonest histological subtype, and the majority of patients are diagnosed with locally advanced or metastatic carcinoma. Since pulmonary infections are common among HIV-infected individuals, clinicians may not suspect lung cancer in this younger patient population. Surgery with curative intent remains the treatment of choice for early stage disease. Although there is increasing experience in using radiation and chemotherapy for HIV-infected patients who do not have surgical options, there is a need for prospective studies for this population frequently excluded from participating in cancer trials. Evidence-based treatments for smoking-cessation with demonstrated efficacy in the general population must be routinely incorporated into the care of HIV-positive smokers.

show abstract

Section: Treatment and Outcomementioning

confidence: 73%

Section: Pathological Findingsmentioning

confidence: 82%

Section: Clinical Characteristicsmentioning

confidence: 99%

Section: Treatment and Outcomementioning

confidence: 99%

See 2 more Smart Citations

Lung Cancer in HIV Infection

Mani

Aboulafia

2014

Cancers in People With HIV and AIDS

Self Cite

View full text Add to dashboard Cite

show abstract

“…However the incidence of lung cancer in HIV infected women appears not to be higher that that in HIV un infected women and the driver of the lung cancer risk is tobacco smoking and not the HIV infection 264 . HIV infected patients with primary lung cancer are younger, tend to present with aggressive and advanced disease and have poorer outcomes 265,266 .…”

Section: Pulmonary Maligancies In Hiv Infected Personsmentioning

confidence: 99%