Human Immunodeficiency Virus and the Trauma Patient

Aa, Guth; Hofstetter,; Hl, Pachter

doi:10.1097/00005373-199608000-00009

Cited by 24 publications

(4 citation statements)

References 37 publications

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“…A study by Guth et al reported similar results. 10 The CD8 level of the trauma group is different than the CD8 level in the other three surgery-based diseases. In trauma patients, the CD8 level of the sepsis group was higher than the level of the non-sepsis group.…”

Section: Resultsmentioning

confidence: 86%

Sepsis risk factors associated with HIV-1 patients undergoing surgery

Feng

Xiu-ling

Jiang

et al. 2015

Emerging Microbes & Infections

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Recent developments in the treatment of HIV-1 have improved the disease prognosis from a terminal disease to a chronic disease. The number of HIV-1-infected patients who require surgery has become more common. The main threat to HIV-1-infected patients following surgery is the development of sepsis. In this study, we collected a large number of clinical recordings of HIV-1-infected patients from two hospitals in China, specializing in HIV-1 treatment in order to summarize the risk indicators of sepsis in HIV-1-infected patients. We compared the significant risk indicators between the sepsis and non-sepsis groups. Using logistic regression based on the indicators of four separate surgery-based diseases, we generally found that low CD4 and hypoalbuminemia counts prior to surgery were the significant risk factors for developing sepsis. The morbidity of sepsis in trauma patients was approximately 10 times higher than the dysfunction group, whereas the tumor and the infection groups were approximately 1.5 and 2 times higher, respectively. Based on the comparison between the sepsis and non-sepsis groups for each surgery-based disease, we found that the severity of trauma is a critical risk factor for trauma patients; therefore, limiting the size of the wound during surgery is crucial. HIV-1-infected patients often develop postoperative sepsis due to immunodeficiency and complications due to the surgery. We hope that this study can help to reduce the risk of developing sepsis due to surgery and improve the survival rate of HIV-1-infected patients.

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Section: Resultsmentioning

confidence: 86%

Sepsis risk factors associated with HIV-1 patients undergoing surgery

Feng

Xiu-ling

Jiang

et al. 2015

Emerging Microbes & Infections

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“…HIV patients have a moderately increased risk of complications, including wound infection (Paiement et al 1994), especially after open fractures. However, it seems that the degree of contamination of the wound in open injuries (Guth et al 1996, Harrison et al 2002) and the lifestyle of the patients (Habermann et al 2008) have more influence on outcome than HIV infection alone. There is increasing evidence both from high-income countries and from LMICs that the end outcomes after surgery in general are no worse for patients with HIV than for other patients (Cacala et al 2006, Duane et al 2008, Stock et al 2010, Patel et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Infection of the fracture hematoma from skeletal traction in an asymptomatic HIV-positive patient

Young¹,

Beniyasi²,

Munthali³

et al. 2012

Acta Orthopaedica

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“…One potential risk factor for SSI is HIV infection. HIV-positive patients may be more susceptible to SSI due to immune dysfunction and other comorbidities associated with HIV [8][9][10][11][12][13][14][15]. However, research on the incidence of Neurosurgical Site Infection (NSSI) in HIV-positive patients is limited and the results have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Clinical Observation and Management of Neurosurgical Site Infection in Patients with and without Human Immunodeficiency Virus (HIV) Infection

2023

J Surg

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Objective:To analyze the clinical difference, potential risk factors and pertinent clinical management of neurosurgical site infection (NSSI) between HIV-positive and HIV-negative patients. Methods:A retrospective analysis was performed on 34 HIV-positive patients and 43 HIV-negative patients who underwent neurosurgical treatments in our department from May 2019 to January 2022. The status of NSSI in the HIV-positive group and the HIV-negative group was compared.Results: There's a statistical difference in the incidence of NSSI between the HIV-positive group and the HIV-negative group. The HIV-positive group was prone to infection and poor healing at the neurosurgical sites, and the incidence of NSSI was related to low body mass index (BMI), hypoalbuminemia, and non-standard antibiotic use in the HIV-positive group. Furthermore, it is statistically different in CD4＋T cell count, serum albumin level and antibiotic use for the HIV-positive patients with and without SSI: Patients with low CD4＋T count, hypoalbuminemia, and non-standard antibiotic use were prone to SSI. Conclusions:To reduce NSSI, perioperative CD4＋T, serum albumin level and BMI of HIV-positive patients should be increased as much as possible to enhance the immune status of patients, and the rational use of perioperative antibiotics should be strengthened.

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Human Immunodeficiency Virus and the Trauma Patient

Abstract: Despite the profound immunosuppression in this group of patients, the incidence of bacterial infectious complications was independent of the CD4+ count (p = 0.958), but was associated with increases in the ISS (p = 0.003).

Cited by 24 publications

References 37 publications

Sepsis risk factors associated with HIV-1 patients undergoing surgery

Sepsis risk factors associated with HIV-1 patients undergoing surgery

Infection of the fracture hematoma from skeletal traction in an asymptomatic HIV-positive patient

Clinical Observation and Management of Neurosurgical Site Infection in Patients with and without Human Immunodeficiency Virus (HIV) Infection

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