Human immunodeficiency virus and pemphigus vulgaris: An interesting association

Marfatia, YS; Patel, S.; Makrandi, Smita; Sharma, Priyanka

doi:10.4103/0378-6323.35745

Cited by 13 publications

(8 citation statements)

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“…Marfatia et al reported a case of PV that did not respond to usual doses of parenteral corticosteroids. [84] After initiation of antiretroviral therapy, the steroid could be tapered off consequent to improvement in skin lesions.…”

Section: Difficult Issuesmentioning

confidence: 99%

Pemphigus in India

Kanwar¹,

De²

2011

Indian J Dermatol Venereol Leprol

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Pemphigus is a chronic epidermal immunobullous disease with potentially fatal outcome. The journey of literature on pemphigus in India has come a long way in last five decades. Pemphigus in Indian patients has unique genetic, clinical, and epidemiological differences from those in the Western countries. Corticosteroids remain the mainstay of treatment for pemphigus. Dexamethasone-cyclophosphamide pulse therapy has revolutionized the management of pemphigus in India and abroad for nearly 3 decades now. Corticosteroid-based treatment, along with adjuvants, has significantly brought down the high mortality rates that had been observed in precorticosteroid era. Present day research is largely based on elucidating the pathogenesis beyond the antidesmoglein antibodies, and newer diagnostic and treatment approaches. In this article, we review various aspects of literature on pemphigus in India, on Indians abroad, or literature from other countries that are considered relevant to the topic.

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Section: Difficult Issuesmentioning

confidence: 99%

Pemphigus in India

Kanwar¹,

De²

2011

Indian J Dermatol Venereol Leprol

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“…HIV infection in patients with ABD is rarely reported. Pemphigus vegetans, pemphigus vulgaris, bullous pemphigoid, epidermolysis bullosa acquisita and cicatricial pemphigoid have been associated with HIV infection in individual case reports.…”

Section: Human Immunodeficiency Virusmentioning

confidence: 99%

Evidence-based guidelines for laboratory screening for infectious diseases before initiation of systemic immunosuppressive agents in patients with autoimmune bullous dermatoses

et al. 2014

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Autoimmune bullous dermatoses (ABD) compromise the skin's innate barrier function for preventing infection. Treating patients with ABD frequently requires systemic immunosuppressive therapy, often with multiple agents. Currently, no pretreatment infection testing guidelines are available for clinicians caring for patients with ABD. We performed a systematic literature review in other medical disciplines that use similar iatrogenic immunosuppressive medications to treat various diseases and conditions and developed infection-testing recommendations for patients with ABD before initiating immunosuppressive therapy. Assessing individual patient risk factors for latent infection and preventable communicable diseases can direct testing for select infections before starting immunosuppressive therapy. Testing patients for hepatitis B virus, hepatitis C virus, and Mycobacterium tuberculosis infection is recommended before initiating rituximab treatment.

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“…Six cases of pemphigus vulgaris (PV) have been reported in patients with HIV ( Table 2 ; Capizzi et al, 1998 , Hodgson et al, 2003 , Marfatia et al, 2007 , Mignona et al, 2005 , Polansky et al, 2015 , Splaver et al, 2000 ). All but one patient was male, and patients ranged from age 29 to 59 years with an average age of 39 years.…”

Section: Autoimmune Blistering Disorders In Hiv/aidsmentioning

confidence: 99%

“…Autoimmune blistering disorders (AIBDs) comprise a heterogeneous group of diseases that are characterized by autoantibodies directed against adhesion proteins in the skin and mucous membranes. Cases of AIBD in patients with HIV have also been increasingly reported, and in some instances the initial clinical presentation of AIBD compels a workup that reveals a previously unknown positive HIV status ( Chou et al, 1991 , Lateef et al, 1999 , Marfatia et al, 2007 , Singh et al, 2014 ). Interestingly, pemphigus vulgaris and bullous pemphigoid-like antibodies have been reported as detectable in the blood of up to 33% of patients with AIDS.…”

Section: Introductionmentioning

confidence: 99%

Autoimmune blistering disorders in the setting of human immunodeficiency virus infection

Min

Damstetter²,

Chen

2018

International Journal of Women's Dermatology

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The interplay between immune dysfunction and human immunodeficiency virus (HIV) is complex. Reports of autoimmune disorders including autoimmune bullous disorders (AIBDs) have been increasing in prevalence in the HIV population since the introduction of highly active antiretroviral therapy in 1995. We offer a literature review of clinical experiences in various AIBDs with particular emphasis on therapeutic management as well as a brief overview of the mechanisms that explain the relationship between AIBD and HIV. Because immunosuppressants are first-line therapies for AIBD treatment, careful consideration is warranted when considering management in the HIV population.

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Human immunodeficiency virus and pemphigus vulgaris: An interesting association

Cited by 13 publications

References 0 publications

Pemphigus in India

Pemphigus in India

Evidence-based guidelines for laboratory screening for infectious diseases before initiation of systemic immunosuppressive agents in patients with autoimmune bullous dermatoses

Autoimmune blistering disorders in the setting of human immunodeficiency virus infection

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