Human immunodeficiency virus and AIDS and other important predictors of maternal mortality in Mulago Hospital Complex Kampala Uganda

Wandabwa, Julius; Doyle, Pat; Longo-Mbenza, Benjamin; Kowal, Paul; Khainza, Betty; Othieno, Emmanuel; Maconichie, N

doi:10.1186/1471-2458-11-565

Cited by 17 publications

(16 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the study did not compare the MMR for HIV‐infected women with those who were uninfected; therefore it is not known if the risk was reduced to the general population level. In a recent systematic review addressing the contribution of HIV to pregnancy related death, no difference in the pooled relative risk of mortality was seen in HIV‐infected pregnant or postpartum women in studies done during a time when ART was available compared with studies done in an era in which ART was not available [7,12]. However, as pointed out in that review, the studies varied by region and criteria for initiation of ART, limiting ART to women with very low CD4 counts.…”

Section: Effect Of Antiretroviral Treatment On Maternal Mortalitymentioning

confidence: 97%

“…Most pregnant women would either not have had access to ART or received it only at the time of delivery. It is likely that the relative risk of death would be lower in treated pregnant women if all HIV‐infected pregnant and postpartum women were on ART [7].…”

Section: Effect Of Antiretroviral Treatment On Maternal Mortalitymentioning

confidence: 99%

“…The HIV pandemic has contributed to this lack of progress. HIV‐infected pregnant women have two to 10 times the risk of dying during pregnancy and the postpartum period compared with uninfected pregnant women [4–8].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

HIV and maternal mortality

Lathrop

Jamieson

Danel

2014

International Journal of Gynecology & Obstetrics

View full text Add to dashboard Cite

The majority of the 17 million women globally that are estimated to be infected with HIV live in Sub-Saharan Africa. Worldwide, HIV-related causes contributed to 19 000–56 000 maternal deaths in 2011 (6%–20% of maternal deaths). HIV-infected pregnant women have two to 10 times the risk of dying during pregnancy and the postpartum period compared with uninfected pregnant women. Many of these deaths can be prevented with the implementation of high-quality obstetric care, prevention and treatment of common co-infections, and treatment of HIV with ART. The paper summarizes what is known about HIV disease progression in pregnancy, specific causes of HIV-related maternal deaths, and the potential impact of treatment with antiretroviral therapy on maternal mortality. Recommendations are proposed for improving maternal health and decreasing maternal mortality among HIV-infected women based on existing evidence.

show abstract

Section: Effect Of Antiretroviral Treatment On Maternal Mortalitymentioning

confidence: 97%

Section: Effect Of Antiretroviral Treatment On Maternal Mortalitymentioning

confidence: 99%

See 1 more Smart Citation

HIV and maternal mortality

Lathrop

Jamieson

Danel

2014

International Journal of Gynecology & Obstetrics

View full text Add to dashboard Cite

show abstract

“…9,15,18 Marital status was not related to SMM in most studies. 4,15,18,19 Employment status had strong association with SMM. Kayem et al 10 conducted a cohort analysis using maternal death databases on risk factors for progression from SMM to death and found that women from unemployed or routine or manual occupational groups appeared to be more likely to progress to death.…”

Section: Sociodemographic Characteristicsmentioning

confidence: 96%

Contributory Factors for Severe Maternal Morbidity

Norhayati

Hussain

Sulaiman

et al. 2015

Asia Pac J Public Health

View full text Add to dashboard Cite

Maternal morbidity is a concept of increasing interest in maternal health. This review aims to assess the contributory factors for severe maternal morbidity over the past one decade worldwide. A comprehensive electronic search was conducted. The search was restricted to articles written in the English language published from 2004 to 2013. Qualitative studies were excluded. A total of 24 full articles were retrieved of which 9 cohort, 7 case-control, 3 cross-sectional studies, and 5 unmentioned designs were included. The contributory factors were divided into 3 components: (a) sociodemographic characteristics, (b) medical and gynecological history, and (c) past and present obstetric performance. This review informs emerging knowledge regarding contributory factors for severe maternal morbidity and has implications for education, clinical practice and intervention. It enables a better understanding of the problem and serves as a foundation for the development of an effective preventive strategy for maternal morbidity and mortality.

show abstract

“…In a study conducted in Mulago hospital, pre-eclampsia/eclampsia contributed to 12% maternal deaths among women admitted with severe maternal morbidity [7]. Pre-eclampsia contributes to neonatal morbidity and mortality.…”

Section: Introductionmentioning

confidence: 99%

The effects of vitamin C supplementation on pre-eclampsia in Mulago Hospital, Kampala, Uganda: a randomized placebo controlled clinical trial

Kowal

Wamuyu-Maina

Wandabwa

et al. 2014

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

BackgroundOxidative stress plays a role in the pathogenesis of pre-eclampsia. Supplementing women with antioxidants during pregnancy may reduce oxidative stress and thereby prevent or delay the onset pre-eclampsia. The objective of this study was to evaluate the effect of supplementing vitamin C in pregnancy on the incidence of pre-eclampsia, at Mulago hospital, Kampala, Uganda.MethodsThis was a (parallel, balanced randomization, 1:1) placebo randomized controlled trial conducted at Mulago hospital, Department of Obstetrics and Gynecology. Participants included in this study were pregnant women aged 15-42 years, who lived 15 km or less from the hospital with gestational ages between 12-22 weeks. The women were randomized to take 1000mg of vitamin C (as ascorbic acid) or a placebo daily until they delivered. The primary outcome was pre-eclamsia. Secondary outcomes were: severe pre-eclampsia, gestational hypertension, preterm delivery, low birth weight and still birth delivery. Participants were 932 pregnant women randomized into one of the two treatment arms in a ratio of 1:1. The participants, the care providers and those assessing the outcomes were blinded to the study allocation.ResultsOf the 932 women recruited; 466 were randomized to the vitamin and 466 to the placebo group. Recruitment of participants was from November 2011 to June 2012 and follow up was up to January 2013. Outcome data was available 415 women in the vitamin group and 418 women in the placebo group.There were no differences in vitamin and placebo groups in the incidence of pre-eclampsia (3.1% versus 4.1%; RR 0.77; 95% CI: 0.37-1.56), severe pre-eclampsia (1.2% versus 1.0%; RR 1.25; 95% CI: 0.34-4.65), gestational hypertension(7.7% versus 11.5%; RR 0.67; 95% CI: 0.43-1.03), preterm delivery (11.3% versus 12.2%; RR 0.92; 95% CI: 0.63-1.34), low birth weight (11.1% versus 10.3%; RR 1.07; 95% CI: 0.72-1.59) and still birth delivery (4.6% versus 4.5%; RR 1.01; 95% CI: 0.54-1.87).ConclusionsSupplementation with vitamin C did not reduce the incidence of pre-eclampsia nor did it reduce the adverse maternal or neonatal outcomes. We do not recommend the use of vitamin C in pregnancy to prevent pre-eclampsia.Trial registrationThis study was registered at the Pan African Clinical Trial Registry, PACTR201210000418271 on 25th October 2012.

show abstract

Human immunodeficiency virus and AIDS and other important predictors of maternal mortality in Mulago Hospital Complex Kampala Uganda

Cited by 17 publications

References 24 publications

HIV and maternal mortality

HIV and maternal mortality

Contributory Factors for Severe Maternal Morbidity

The effects of vitamin C supplementation on pre-eclampsia in Mulago Hospital, Kampala, Uganda: a randomized placebo controlled clinical trial

Contact Info

Product

Resources

About