Human immune response to polydimethylsiloxane (silicone): screening studies in a breast implant population

Wolf, Laurence E.; Lappé, Marc; Peterson, Robert D.; Ezrailson, Edward G.

doi:10.1096/fasebj.7.13.8405812

Cited by 67 publications

(27 citation statements)

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“…[16] Silicone fluids can also interact with proteins and structurally related polymers. [17] It has been shown that dimethylsilicones are not themselves immunogenic [18] but, when emulsified with immunogenic proteins, lead to higher immune responses. That is, silicones behave as adjuvants.…”

mentioning

confidence: 99%

Protein-Silicone Interactions

Bartzoka

McDermott

Brook³

1999

Adv. Mater.

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Silicone polymers (polydimethylsiloxanes, (Me 2 SiO) n , PDMSs) have been exploited in a variety of personal care [1] and medically related [2] applications. For instance, liquid silicones are used as oral defoamers in anti-acid formulations, [3] and as carriers for cosmetics and deodorants; [4] silicone elastomers are used in medical-grade tubing, transdermal drug delivery patches, and implanted prostheses (an application that has caused much controversy); [5] and silicone±polyether copolymers are used in hair-care applications.[4] The properties that make silicones particularly appropriate for these applications include hydrophobicity, low glass transition temperature T g (typically less than ±120 C [6]

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mentioning

confidence: 99%

Protein-Silicone Interactions

Bartzoka

McDermott

Brook³

1999

Adv. Mater.

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“…Women having been implanted with silicone breast prostheses have statistically higher levels of anti-silicone IgG [15]. Since 1960, polymethylmethacrylate has been shown to be immunologically inactive as an implant material.…”

Section: Discussionmentioning

confidence: 99%

A New Testis Prosthesis Material: Polymethylmethacrylate

Karademir¹,

Şenkul²,

Demir³

et al. 2004

Urol Int

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Introduction: Silicone has been the standard prosthesis material for the last three decades but new materials are being searched because of the known disadvantages of silicone such as migration and high cost. We wanted to test in rats whether or not polymethylmethacrylate could be an alternative to silicone. Materials and Medhods: We prepared polymethylmethacrylate and silicone testis prostheses which were similar to testis size of rats. Eleven rats were implanted with polymethylmethacrylate, 11 others were implanted with a silicone prosthesis and sham operation was performed in 10 rats. Three months later the scrotums of the animals were removed with the prosthesis for a quantitative analysis of the chronic inflammation and fibrotic reaction and to measure the thickness of the capsule. Result: Rejection and infection were not observed in any of the prosthesis-implanted rats. Both prosthesis groups displayed increased vascularization, hemosiderin accumulation and fibrotic and hyalinized tissue formation that replaced the muscle. Chronic inflammation was measured and found to be higher in the polymethylmethacrylate group and the difference was not found to be significant. The average thicknesses of the capsules around the polymethylmethacrylate and silicone groups were found to be 58.4 and 46.8 µm, respectively, and that difference was not significant again. Conclusions: In the short term polymethylmethacrylate was equally well tolerated, but the low cost of polymethylmethacrylate made it more advantageous.

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“…In other studies it has been hypothesised that silicone could induce an autoimmune response. Elevated levels of anticollagen autoantibodies in women with silicone implants were reported [6,7], with the highest being found in women whose implants had ruptured or leaked [20]. Solomon et al [5] evaluated 176 symptomatic patients with silicone breast implants, nearly 50% of whom required explantation because of capsular contracture or rupture.…”

Section: Discussionmentioning

confidence: 99%

A Prospective Study on Silicone Breast Implants and the Silicone-Related Symptom Complex

et al. 2002

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This cohort study prospectively evaluated the prevalence of the silicone-related symptom complex (SRSC) in relation to antinuclear antibodies (ANA) and magnetic resonance imaging (MRI) of silicone breast implants (SBI) 1 year after implantation. A total of 57 women undergoing mastectomy followed by immediate breast reconstruction (IBR) and SBI between March 1995 and March 1997 at the University Hospital Rotterdam/Daniel den Hoed Cancer Centre, were prospectively evaluated. Just before and 1 year after IBR the sera of these women were tested for the presence of ANA and they were screened for the prevalence of SRSC-related symptoms by questionnaire. All prostheses were evaluated by MRI 1 month and 1 year after IBR. Just before operation 11% of the women had a Sjögren score of more than 2, whereas 30% had such a score 1 year after IBR ( P = 0.01). One year postoperatively women had significantly more RA/Raynaud-related complaints: 21% preoperatively versus 40% 1 year after IBR ( P = 0.03). Within the undefined complaints-related group 19% had a score of 2 or more preoperatively and 33% 1 year after IBR ( P = 0.09). There were no new cases of ANA positivity 1 year after IBR. The linguine sign was seen by MRI in three implants: one 1 month after IBR and two 1 year after IBR. There was no relation to changes in SRSC expression and these MRI findings. In conclusion, 1 year after SBI implantation women had more SRSC-related complaints, especially Sjögren's and RA/Raynaud's. Moreover there was no correlation between elevated SRSC expression and changes in the presence of ANA or changes in MRI of the SBI 1 year after IBR.

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Human immune response to polydimethylsiloxane (silicone): screening studies in a breast implant population

Cited by 67 publications

References 0 publications

Protein-Silicone Interactions

Protein-Silicone Interactions

A New Testis Prosthesis Material: Polymethylmethacrylate

A Prospective Study on Silicone Breast Implants and the Silicone-Related Symptom Complex

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