Human Immature Dental Pulp Stem Cells (hIDPSCs), Their Application to Cell Therapy and Bioengineering: An Analysis by Systematic Revision of the Last Decade of Literature

Abstract

During recent years, attention has been given to the potential of therapeutic approaches using stem cells obtained from dental pulp tissue. The aim of this study, therefore, was to give an overview of the papers produced during the last 10 years that have described the use of stem cells obtained from human deciduous teeth in cell therapy or bioengineering. The PubMed database was investigated from January 2002 until July 2011 and the papers published during this period were analyzed according to criteria previously established, using the methodology of systematic review. The measurements were done using "stem cell" as the primary keyword, and "human deciduous teeth dental pulp cell" and "human exfoliated deciduous teeth" as the secondary keywords. Four hundred and seventy-five papers were found. The first screening resulted in 276 papers, from which 84 papers were selected. However, only 11 of them attained the aim proposed in our approach. There were few scientific studies related to direct therapeutic application using stem cells of human deciduous teeth and none of them had been applied to humans. However, the results indicated important and promising applications of the pulp stem-cells in cell therapy and bioengineering as demonstrated by studies in animal models of muscular dystrophy, Parkison's disease, and lupus erythematosus.

Scientific Basis of Dentistry

“…At the beginning of the twenty-first century, in the same way that stem cells can be used for the treatment of diseases from muscular dystrophy to the regeneration of brain tissue, the most important dental studies are those related with dental pulp stem cells. After the first discovery of DPSCs in 2000, many studies have been performed ( 8 , 9 , 10 ). The first human trial for cornea replacement in a rabbit model with human immature dental pulp stem cells (hIDPSCs) was conducted in 2010.…”

Fractal and gray level co-occurrence matrix texture analysis of senescent and non-senescent deciduous teeth stem cells: A pilot study

“…Since they can be easily obtained from teeth during routine dental procedures, especially DPSCs from human deciduous teeth (also known as deciduous teeth stem cells, DTSCs), have gained a very large attention in recent years from a potential therapeutic standpoint [2].…”

Teeth‐derived stem cells: A source for cell therapy

“…They are generated from naturally exfoliated deciduous teeth that are usually discarded in childhood as medical waste. The use of IDPSCs has almost resolved the ethical concerns about the application of embryonicderived stem cells (De Souza et al, 2013). Therapeutic potential of IDPSCs has been studied in muscular dystrophy (Kerkis et al, 2008), corneal regeneration (Gomes et al, 2010), and chronic spinal cord injury investigations (Feitosa et al, 2017).…”