Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor

Budesonide treatment is associated with increased bile acid absorption in collagenous colitis

“…23,24 Thus, the normalization of the 75 SeHCAT values suggests that the symptomatic effect of budesonide treatment in collagenous colitis may in part be due to less BAs reaching the colon, which in fact has also been suggested for Crohn's disease. 17 Our findings are consistent with the report of transactivation of the human BA transporter gene (SLC10A2) by budesonide in healthy subjects. 17 This gene is coding for the ASBT, the protein responsible for the active uptake of BAs in the small bowel.…”

“…17 Our findings are consistent with the report of transactivation of the human BA transporter gene (SLC10A2) by budesonide in healthy subjects. 17 This gene is coding for the ASBT, the protein responsible for the active uptake of BAs in the small bowel. If budesonide treatment stimulates ASBT expression also in patients with collagenous colitis, the rate of BA uptake will enhance which leads to higher 75 SeHCAT values.…”

Microscopic colitis: clinical findings, topography and persistence of histopathological subgroups

“…The efficacy of budesonide reported by all three subgroups (Table 5a,b) confirms the results of controlled trials, 49 and was independent of the SeHCAT results (Table 5a,b). The efficacy of budesonide could be related to the restoration of normal eosinophil and T-cell activation, 50 amplification of the bile acid transporter 51,52 and decreased colonic secretion. 53 In conclusion, we propose that CC and LC be considered one clinical entity, and could be entered into the same clinical trials using stratification for subtype.…”

Beyond CAR and PXR

“…At the level of the intestine, the ileal reabsorption of BAs is facilitated by apical sodium-dependent bile salt transporter (ASBT, SLC10A2). ASBT is repressed by BAs in humans and mouse but not in rats [39,40], and FXR appears to prevent the binding of LRH-1 and RAR-RXR heterodimers to the mouse Asbt promoter and may play a role in suppression of ASBT expression [41].…”