Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: Current knowledge and perspectives

Corrao, Simona; Campanella, Claudia; Anzalone, Rita; Farina, Felicia; Zummo, Giovanni; Macario, Everly Conway de; Macario, Alberto J. L.; Cappello, Francesco; Rocca, Giampiero La

doi:10.1016/j.lfs.2009.11.004

Cited by 68 publications

(62 citation statements)

References 78 publications

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“…As depicted in Table 1, and as reported by us and others, HLA-G is expressed by WJ-MSC [16,47] and BM-MSC [48]. HLA-G has a key role in tolerance induction of the mother's immune system towards the semi-allogeneic foetus during pregnancy; it acts together with other class Ib MHC molecules (such as HLA-E and HLA-F) and trophoblast-secreted factors as EPF (early pregnancy factor) [77,78]. To this regard, we recently demonstrated for the first time that WJ-MSC do express also other class Ib MHC molecules, namely HLA-E and HLA-F [45]: both are implicated in tolerogenic processes occurring at the foetomaternal interface, together with HLA-G [79][80][81].…”

Section: Recent Data On the Expression Of Relevant Immunomodulatory Mmentioning

confidence: 56%

Novel Immunomodulatory Markers Expressed by Human WJ-MSC: an Updated Review in Regenerative and Reparative Medicine

Rocca¹,

Corrao

Iacono

et al. 2012

TOTERMJ

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Mesenchymal (stromal) stem cells (MSC) are a broad class of stromal populations which are able to differentiate towards mature cell types, and do express molecules involved in immune modulation, tolerance induction and inflammation dampening. MSC can be virtually isolated from each adult organ, as well as from foetus-associated perinatal tissues. In particular, Wharton's jelly-derived MSC (WJ-MSC) bear all of these key properties, together with their ease of sourcing and lack of ethical issues.Cellular therapy is a key technique in regenerative medicine approaches, in particular for the treatment of diseases in which physiological processes of cellular repopulation are blocked by the underlying pathological conditions. Recent data enlightened the ability of administered cells to act also in a repopulation-independent fashion in target organs, since their peculiar immunomodulatory and anti-inflammatory features may favor organ self-repair by reactivating local progenitors by both cell-mediated or paracrine mechanisms. Translating classical regenerative medicine to "reparative medicine" or "support medicine" should represent a further therapeutic strategy independent from the differentiation capacity of MSC populations.Recent data further highlighted that WJ-MSC outperform BM-MSC (which are now being applied clinically) both in terms of immune modulation and lack of tumorigenesis (or tumor-promoting activities) in vivo. Starting from these premises, this paper analyzes the recent data on the biology of WJ-MSC, considering the role of both naïve and differentiated cells in immune modulation. In particular, the role of tolerance promoting pathways via non-classical B7 costimulators or class Ib MHC molecules are examined. In addition, we also analyzed the interconnections with other mechanicistic pathways (as those driven by matrix degrading metalloproteinases) in immune modulation. Our observations strongly support the notion that WJ-MSC may constitute a new tool in regenerative and reparative medicine applications.

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Section: Recent Data On the Expression Of Relevant Immunomodulatory Mmentioning

confidence: 56%

Novel Immunomodulatory Markers Expressed by Human WJ-MSC: an Updated Review in Regenerative and Reparative Medicine

Rocca¹,

Corrao

Iacono

et al. 2012

TOTERMJ

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“…It is not clear if cHSP60 forms the same heptameric structure, i.e. the "barrel" that it forms inside the mitochondria, or if it interacts with HSP10 as it does inside mitochondria [9]. cHSP60 has been shown to display functions distinct from those of the intramitochondrial counterpart (that is dedicated to assisting protein folding).…”

Section: Hsp60 Has Anti-apoptotic Effects In Cardio-myocytesmentioning

confidence: 99%

“…HSP60 is the human mitochondrial chaperonin that works in conjunction with its co-chaperonin HSP10 to facilitate protein folding [9]. Due to its key role in supporting mitochondrial functionality, HSP60 has been regarded as one of the most important proteins for cell survival.…”

Section: Introductionmentioning

confidence: 99%

Heat Shock Protein-60 and Risk for Cardiovascular Disease

Rizzo¹,

Macario²,

Macario³

et al. 2011

CPD

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Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. There is growing evidence that molecular chaperones, many of which are heat shock proteins HSPs, are involved in CVD pathogenesis. In this review we focus on HSP60, the human mitochondrial chaperone that also displays extramitochondrial and extracellular functions. HSP60 is typically cytoprotective but a number of stress conditions determine its conversion to a potentially toxic molecule for cells and tissues. We present illustrative examples of specific subtypes of CVD where HSP60 is implicated in the initiation and/or progression of disease. The data not only indicate a pathogenic role for HSP60 but also its potential as a biomarker with applications for diagnosis, assessing prognosis and response to treatment, as well as for preventing and treating CVD.

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“…The inflamed colon tissue would react with a higher rate of protein synthesis, and consequently, it would have a pressing need for the folding of new polypeptides in the face of protein destruction due to the pathological process linked to inflammation. Self-HSPs would be increased as a response to a situation in which the cell needs more of them, but this situation would not necessarily be typical of IBD since it can also occur in other pathologies with inflammation and tissue destruction [64][65][66][67]. Elevated levels of self-HSPs would reflect an anti-pathogenic mechanism, and they could be used as indicators of disease and, thus, could have some value as diagnostic markers, and in assessing prognosis and response to treatment.…”

Section: Probiotics: From Definition To Therapeutic Usementioning

confidence: 99%

Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis

Bellavia

Tomasello

Romeo

et al. 2013

Med Microbiol Immunol

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In this work, we propose that for further studies of the physiopathology and treatment for inflammatory bowel diseases, an integral view of the conditions, including the triad of microbiota-heat shock proteins (HSPs)-probiotics, ought to be considered. Microbiota is the complex microbial flora that resides in the gut, affecting not only gut functions but also the health status of the whole body. Alteration in the microbiota's composition has been implicated in a variety of pathological conditions (e.g., ulcerative colitis, UC), involving both gut and extraintestinal tissues and organs. Some of these pathologies are also associated with an altered expression of HSPs (chaperones) and this is the reason why they may be considered chaperonopathies. Probiotics, which are live microorganisms able to restore the correct, healthy equilibrium of microbiota composition, can ameliorate symptoms in patients suffering from UC and modulate expression levels of HSPs. However, currently probiotic therapy follows ex-adiuvantibus criteria, i.e., treatments with beneficial effects but whose mechanism of action is unknown, which should be changed so the probiotics needed in each case are predetermined on the basis of the patient's microbiota. Consequently, efforts are necessary to develop diagnostic tools for elucidating levels and distribution of HSPs and the microbiota composition (microbiota fingerprint) of each subject and, thus, guide specific probiotic therapy, tailored to meet the needs of the patient. Microbiota fingerprinting ought to include molecular biology techniques for 123Med Microbiol Immunol DOI 10.1007/s00430-013-0305-2 sequencing highly conserved DNA, e.g., genes encoding 16S RNA, for species identification and, in addition, quantification of each relevant microbe.

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Human Hsp10 and Early Pregnancy Factor (EPF) and their relationship and involvement in cancer and immunity: Current knowledge and perspectives

Cited by 68 publications

References 78 publications

Novel Immunomodulatory Markers Expressed by Human WJ-MSC: an Updated Review in Regenerative and Reparative Medicine

Novel Immunomodulatory Markers Expressed by Human WJ-MSC: an Updated Review in Regenerative and Reparative Medicine

Heat Shock Protein-60 and Risk for Cardiovascular Disease

Gut microbiota imbalance and chaperoning system malfunction are central to ulcerative colitis pathogenesis and can be counteracted with specifically designed probiotics: a working hypothesis

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