Human high-affinity Fc?RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization

Abstract

The human Fc gamma RI gene encodes for a high-affinity Fc gamma receptor that plays pivotal roles in the immune response. We have used fluorescence in situ hybridization analysis to localize the Fc gamma RI gene to human chromosome 1. The human Fc gamma RI (CD64) gene has been assigned to human chromosome 1q21.2-q21.3 using R-banded human (pro)metaphase chromosomes.

Localization of FCGR1 encoding Fcγ receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1

“…There remains no consensus for the sub-band location of FCGR1A and FCGR1C within 1q21. While others have mapped some of the FCGR1 genes to either 1q21.1 (de Wit et al, 1993) or 1q21.2 → q21.3 (Takai et al, 1994), we did not attempt to sublocalize FCGR1 in this study. However, the fact that seven human chromosomes 1 yielded separate signals for FCGR1A and FCGR1C at 1q21 leads us to estimate that these genes are located approximately 500-1,000 kb apart (Lichter et al, 1990;Laan et al, 1996).…”

The role of genetic polymorphisms in periodontitis

“…FcR profile and gene polymorphisms. The human leukocyte Fc γ R family consists of three major classes, and encompasses eight genes (CD64: Fc γ RIA, IB, and IC; CD32: Fc γ RIIA, IIB and IIC; CD16: Fc γ RIIIA and IIIB), which have been mapped to the long arm of chromosome 1 (1q21 and 1q23–24) (144, 205, 238). Most Fc γ R subclasses consist of a separate ligand‐binding chain with an extracellular domain that contains the immunoglobulin G‐binding region, and signaling chains essential for the initiation of signal transduction.…”

The therapeutical approaches for rare diseases through the immune processes of IgG Fc Receptors

“…The second signifi cance was that the sole type of the FcRIIA identifi ed on these cells (megakaryocytes, megakaryoblasts and the CD34 expressing cell lines, KG-1 and KG-1a can be used as an identifi cation marker in hematopoietic lineage differentiation stage. Three very similar genes (A, B and C) have been characterized for Fc type I located on chromosome 1q21.2 by the gene cloning studies [43][44][45][46]. Six variants transcripts of the FcR type I were further identifi ed [47].…”