Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case‐control study in a sub‐Saharan African population with diabetes

Abstract

In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.

TYK2 Promoter Variant Is Associated with Impaired Insulin Secretion and Lower Insulin Resistance in Japanese Type 2 Diabetes Patients

“…On the other hand, Gkrania-Klotsas et al reported that the prevalence of Coxsackievirus B neutralizing antibodies was not different between the type 2 diabetes patients and the subjects without diabetes [22]. In the type 2 diabetes patients of sub-Saharan African, positive human herpesvirus 8 DNA associated with lower insulin secretion and lower BMI comparing with the type 2 diabetes patients without human herpesvirus 8 infection [23]. Similarly, hepatitis C virus infection associates with the lower insulin secretion in the type 2 diabetes patients [24].…”

Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland

“…It is suggested that enterovirus, cytomegalovirus, mumps virus, parvovirus, rubella virus, and rotaviruses may be crucial in that process. Lontchi-Yimagou et al [24] showed that HHV-8 infections are associated with low insulin secretion. Moreover, differences in the ORF 26 sequence were found in 30% of the HHV-8 strains isolated from lymphocytes, prompting the authors to hypothesis the existence of a new HHV-8 virus sub-type [1,3].…”

Human Herpesvirus 8 and Host-Cell Interaction: Long-Lasting Physiological Modifications, Inflammation and Related Chronic Diseases

“…In particular, HCV has been reported as causing diabetes by its direct action on liver metabolism and also by the activation of a specific immune response that may cause tissue damage, whereas a strong epidemiological association with HHV8 has been described in the last decade [65,75,78,81,82,86]. In a recent paper, Lontchi-Yimagou et al [89] studied insulin secretion in HHV8-positive and -negative sub-Saharan African subjects with DMT2. In the diabetic population, they did not find any significant differences in metabolic parameters between patients with or without HHV8 antibodies.…”

“…Moreover, the dysfunction of endothelial cells has been involved in the pathophysiology of metabolic diseases and DMT2 [90,91], and endothelial dysfunction is believed to contribute to the clinical expression of atherosclerosis and other complications of diabetes [92]. Overall, several findings have led to the hypothesis that HHV8 could be implicated in inducing some metabolic alterations, such as the increase of insulin binding and glucose uptake, which may be the initial event for activating the metabolic syndrome and diabetes [60,77,78,81,82,89,93]. It is commonly accepted that insulin hyper-secretion is considered a triggering cause of diabetes, and the discovery of the causes that are linked to insulin hyper-secretion is fundamental in the design of specific diabetes treatment [94,95].…”

“…On the basis of these considerations, some authors have hypothesized a possible association between chronic HHV8 infection and the onset of chronic diseases such as diabetes. The recent studies performed in the Mediterranean and sub-Saharan Regions have given significant evidence of an epidemiological association between HHV8 infection and DMT2 [77,78,86,89]. Furthermore, the upset of both the glucose and lipid metabolism of endothelial cells has been hypothesized as creating the conditions that favour the metabolic syndrome and decrease in insulin efficiency found in diabetes (Figure 1).…”