Human herpesvirus 8-associated spinal cord lymphoma in an HIV-positive subject

Croxson, M. C.; Taylor, Graeme; Nisbet, Mitzi; Nagappan, Ramesh; Rb, Ellis-Pegler; Water, Neil Van de

doi:10.1080/00313020600820856

Cited by 2 publications

(3 citation statements)

References 26 publications

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“…Since conventional respiratory viruses were not found, further assays were performed looking for viruses known to be capable of establishing persistent infection, namely human herpes‐6 (HHV‐6) and Epstein‐Barr virus (EBV) using PCR techniques with published primers 32,33. Low‐titer HHV‐6 was found in samples from 3 of 8 CRSsNP patients, 4 of 5 CRSwNP patients, and 1 of 2 normal subjects.…”

Section: Resultsmentioning

confidence: 99%

Is chronic rhinosinusitis caused by persistent respiratory virus infection?

Wood

Antoszewska

Fraser

et al. 2011

Int Forum Allergy Rhinol

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Section: Resultsmentioning

confidence: 99%

Is chronic rhinosinusitis caused by persistent respiratory virus infection?

Wood

Antoszewska

Fraser

et al. 2011

Int Forum Allergy Rhinol

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“…A high index of suspicion is needed in cases of familial lymphoma, as identifying XLP mutations prior to EBV infection may allow bone marrow transplantation and improve the chances of survival [23]. (1,4,7,10), female control (2,5,8,11), female carrier IV:1 (3,6,9,12). MW: molecular weight markers; 1-3: undigested DNA, GAPDH (positive control); 4-6: undigested DNA, HUMARA; 7-9: MspI-digested, HUMARA; 10-12: HpaII-digested, HUMARA.…”

Section: Discussionmentioning

confidence: 99%

“…EBV detection by real-time PCR The presence of EBV DNA in the proband (V:1) and the grandmother (III:1) was detected and quantified by TaqMan Ò real-time PCR (Applied Biosystems, Foster City, CA, USA). The primers and probes target a 75 base-pair region in the EBVglycoprotein gene (gp350) [12].…”

Section: Methodsmentioning

confidence: 99%

Follicular Lymphoma in a X‐linked Lymphoproliferative Syndrome Carrier Female

Woon¹,

Ameratunga²,

Croxson³

et al. 2008

Scand J Immunol

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X‐linked lymphoproliferative (XLP) syndrome is a rare primary immune‐deficiency disorder caused by mutations of the SH2D1A or XIAP genes. Males with the disorder are usually in good health until contracting Epstein–Barr virus (EBV) whereupon the majority of patients die from fulminant infectious mononucleosis, lymphoma or hypogammaglobulinaemia. This report describes a female carrier with an XLP phenotype who was retrospectively identified after her grandson died from the disorder. Subsequent genetic testing identified the patient's mother and affected maternal grandmother as XLP carriers. The family’s medical records were significant. The proband had lymphoma at ages 2 and 8 and made a full recovery following treatment. Both the maternal grandmother and uncle died of non‐Hodgkin’s lymphoma. We were concerned that the XLP carrier mother may be predisposed to lymphoma if the normal X chromosome is skewed towards inactivation. The human androgen receptor assay detected random X chromosome inactivation in the carrier mother. EBV was not detected in the lymphoma tissues of the proband and his grandmother, confirming previous findings that EBV is not always associated with lymphoma in XLP. More significantly, our study highlights the importance of identifying XLP in families with a high incidence of lymphoma.

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Human herpesvirus 8-associated spinal cord lymphoma in an HIV-positive subject

Cited by 2 publications

References 26 publications

Is chronic rhinosinusitis caused by persistent respiratory virus infection?

Is chronic rhinosinusitis caused by persistent respiratory virus infection?

Follicular Lymphoma in a X‐linked Lymphoproliferative Syndrome Carrier Female

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