Human Herpesvirus 8 as the Infectious Cause of Kaposi Sarcoma

Lebbe, Célèste

doi:10.1001/archderm.134.6.736

Cited by 14 publications

(7 citation statements)

References 45 publications

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“…Nowadays, it is accepted that if HHV-8 is the agent responsible for KS, it has to be present to develop all clinical forms of KS, it is detected in almost 100% of KS lesions, and it is considered a contributing agent but not the only one to develop this neoplasia. [10][11][12][13][14] Besides Peru, there have been > 70 cases of classic KS reported in Colombia, showing that it is a prevalent pathology in South America. 15 An interesting clinical observation from Colombia is that the classic KS seen in their patients resembles the type of disease seen among African communities.…”

Section: Discussionmentioning

confidence: 99%

Is Classic Kaposi’s Sarcoma Endemic in Peru?: Report of a Case in an Indigenous Patient

Mohanna

Maco²,

Gown³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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Abstract. Kaposi's sarcoma (KS) has been classified in four clinical variants (classic or Mediterranean; endemic or African; epidemic or AIDS-related; iatrogenic or immunosuppression-related). Human herpesvirus 8 (HHV-8), has been found in all these variants. We herein discuss the unusual presentation of a 53-year-old indigenous patient with purplish-brown nodular lesions on lower extremities, and miliary tuberculosis. ELISA-HIV tests were negative and immunohistochemistry (IHC) of the tumor tissue was positive for HHV-8. This is the first reported case in which the presence of HHV-8 was evidenced by means of IHC techniques in Peru. We also review all available Peruvian literature of classic KS, a disease that has been frequently reported in indigenous population of Peru since 1968, making this country a possible endemic zone of classic KS.

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Section: Discussionmentioning

confidence: 99%

Is Classic Kaposi’s Sarcoma Endemic in Peru?: Report of a Case in an Indigenous Patient

Mohanna

Maco²,

Gown³

et al. 2006

The American Journal of Tropical Medicine and Hygiene

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“…424 Its role in the etiology of Kaposi's sarcoma in HIV-positive individuals was confirmed in 1994 when unique DNA sequences were isolated from biopsies of Kaposi's sarcoma. 424 Its role in the etiology of Kaposi's sarcoma in HIV-positive individuals was confirmed in 1994 when unique DNA sequences were isolated from biopsies of Kaposi's sarcoma.…”

Section: Human Herpesvirus-8mentioning

confidence: 98%

Viral diseases

Weedon

2010

Weedon's Skin Pathology

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“…Das Kaposi-Sarkom existiert neben der Aids-assoziierten Form endemisch in Afrika und kann auch bei immunkompromittierten Patienten auftreten. Serologische Tests ergaben Seroprä-valenzen, die zwischen 0 und 20% lagen, bei Aids-Patienten bei über 46% [25].…”

Section: Humanes Herpesvirusunclassified

Zum aktuellen Stand der Dermatomikrobiologie

Sonntag

Schwanitz

2002

Hautarzt

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The new German laws dealing with protection against infectious diseases (Infektionsschutzgesetz of 1.1.2001) have reconfirmed the importance of microbiology as a basic science and infectiology as a multi-disciplinary clinical discipline. Concerning dermatological diagnosis and therapy, the implementation of molecular biological techniques has a decisive influence. The discovery of new (e.g. Helicobacter pylori) and the better detection of known organisms (e.g. Chlamydia, Borrelia) suggested findings in questions of causality and therapeutic developments. Concerning the infections of the skin this synopsis provides the state of the art of diagnostic process and treatment in mycology, bacteriology and virology.

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Human Herpesvirus 8 as the Infectious Cause of Kaposi Sarcoma

Cited by 14 publications

References 45 publications

Is Classic Kaposi’s Sarcoma Endemic in Peru?: Report of a Case in an Indigenous Patient

Is Classic Kaposi’s Sarcoma Endemic in Peru?: Report of a Case in an Indigenous Patient

Viral diseases

Zum aktuellen Stand der Dermatomikrobiologie

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