Human herpesvirus‐7 in Brazilian liver transplant recipients: a follow‐up comparison between molecular and immunological assays

Peigo, M.F.; Thomasini, Ronaldo Luis; Puglia, Ana L.P.; Costa, Sandra Cecı́lia Botelho; Bonon, Sandra Helena Alves; Boin, I.F.S.F.; Leonardi, M.I.; Mota, N. G. S.

doi:10.1111/j.1399-3062.2009.00429.x

Cited by 13 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Primary infection rarely comes to clinical attention and is less well understood than with HHV-6B. HHV-7 DNA detection in blood samples after transplantation is primarily due to reactivation and is found in approximately 40–60% of patients [50–52]. This typically occurs within the first 2–4 weeks after transplant.…”

Section: Human Herpesvirusmentioning

confidence: 99%

Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials

Hill

Zerr

2014

Current Opinion in Virology

View full text Add to dashboard Cite

Roseoloviruses frequently reactivate in transplant recipients. We review the impact of Roseoloviruses in transplant recipients and highlight research priorities. Human herpesvirus 6A (HHV-6A) and HHV-6B were recently classified as distinct species with important differences. Both viruses can result in inherited chromosomally integrated HHV-6, which may cause complications after transplant. HHV-6B is the primary species associated with disease and appears to have pleiotropic effects on the central nervous system. Small preemptive and prophylactic studies have not shown a statistically significant impact on HHV-6 disease. Although Roseoloviruses are associated with diverse complications in transplant patients, studies providing strong evidence for a causal role are lacking. Trials focusing on prevention and treatment will be important to inform the significance of Roseolovirus reactivation.

show abstract

Section: Human Herpesvirusmentioning

confidence: 99%

Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials

Hill

Zerr

2014

Current Opinion in Virology

View full text Add to dashboard Cite

show abstract

“…HHV coinfection was considered in case of two or more positive HHV-DNA results in the same serum sample. The following isolated and/or combined symptoms were used to characterize active HHV infection, and/or likely HCMV disease: fever, headache, abdominal pain, seizure, changes in behavior, low levels of consciousness, mental confusion, motor dysfunction, neuropathy, paresthesia, drowsiness, vomiting, weakness, weight loss, myoclonus, memory loss, visual and psychomotor impairment, genital and orofacial herpesvirus, ocular infection, dermatitis, varicella, mononucleosis syndrome, Burkitt's lymphoma, nasopharyngeal carcinoma, Hodgkin's disease, HCMV colitis, retinitis, hepatitis, pneumonitis, roseola infantum or exanthem subitum, Kaposi's sarcoma, primary effusion lymphoma and Cattleman's disease [27][28][29][30][31][32].…”

Section: Criteria For Confirming Hhv Infection or Likely Hcmv Diseasementioning

confidence: 99%

Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score

et al. 2020

View full text Add to dashboard Cite

Background Human herpesviruses (HHVs) are responsible for a significant number of clinical manifestations in systemic lupus erythematous (SLE) patients. The aim of this study was to determine the frequency of active HHV infections in SLE patients and correlating them with disease activity. Methods Serum samples were collected from 71 SLE patients and their DNAs were extracted and analyzed to detect HHV-DNA viruses using the nucleic acid amplification technique. Results Fifteen out of the 71 (21.1%) patients tested positive for the HHV-DNA virus. Of them, 11/15 HHV-DNA-positive patients (73.3%) had SLE activity index (SLEDAI – Systemic Lupus Erythematosus Disease Activity Index) ≥8 (p = 0.0001). Active HCMV infection was the mostly frequently observed infection, occurring in 6/15 patients (40%). The frequencies of other active viral infections were 22% for HSV-1, 16.7% for HHV-7, and 5.5% for HSV-2. Viral coinfection (two or more viruses detected in the same sample) occurred in three patients (16.7%). Active HHV infections in SLE patients are more frequent in those with active SLE (≥8), who is at high risk of HHV reactivation and HCMV disease. Conclusion Viral surveillance is important to identify active HHV infections that can cause clinical symptoms and other complication in SLE patients.

show abstract

“…Active HHV-7 infection: Active HHV-7 infection was defined based on the following criteria: one or more positive Nested-PCR HHV-7-DNA result from serum-extracted DNA [16,17].…”

Section: Definitionsmentioning

confidence: 99%

Betaherpesvirus (Cmv, Hhv-6 and Hhv-7) Active Infections in Brazilian Hematopoietic Stem Cell Transplant Patients

Bonon¹,

Parola²,

Thomasini³

et al. 2011

J Bioanal Biomed

View full text Add to dashboard Cite

Cytomegalovirus (CMV) is one of the most prevalent infectious pathogen in transplant recipients, including those receiving bone marrow or stem cell grafts. Rapid diagnostic tests to identify active CMV infection and preemptive treatment are significant improvements in the management of CMV. Two newly identified beta herpesviruses, human herpesvirus-6 (HHV-6) and human betaherpesvirus-7 (HHV-7), are genetically more closely related to each other than to CMV and have been frequently detected in the blood of allogeneic HSCT. HHV-6 reactivation has been associated with fever, rash, delayed engraftment and encephalitis. Also, HHV-7 has been reported as a cause of severe central nervous system disease and with severe GVHD and sepsis secondary to immune suppression. Nested polymerase chain reaction in blood samples (serum or leukocytes) was used to monitor active CMV, HHV-6 and HHV-7 infections and disease in forty-three HSCT patients for up to 150 days after transplant. All adult recipients with a risk for CMV disease (D+/R+; D+/R-) were enrolled in this study. Acyclovir was used at low doses prior to the transplant as herpes virus prophylactic therapy. Patients who were at least 2 consecutive N-PCR positive for CMV received preemptive therapy with ganciclovir. The prevalence's of positive active CMV, HHV-6 and HHV-7 infections were 72%, 4.6% and 13.9%, respectively. Thirteen patients died (30.2%). Biopsies confirmed CMV disease occurred in 8 out of 43 patients (18.6%), in the gastrointestinal tract. All of them presented active CMV infection and one presented active CMV+HHV-6 infection. None of these patients presented active HHV-7 infection. One patient with CMV disease died by disseminated CMV. Detection of active HHV-6 and HHV-7 infections was low and clinically significant complications were rare. CMV disease remains the most prominent disease associated with HSCT. Results show that surveillance with N-PCR ─ a sensitive, non-invasive and low-cost technique for detection of active beta herpesvirus infections ─ can be used when antigenemia or DNA quantitative methods are unavailable, because patients with a propensity for developing CMV disease can be readily identified and pre-emptive therapy started.

show abstract

Human herpesvirus‐7 in Brazilian liver transplant recipients: a follow‐up comparison between molecular and immunological assays

Cited by 13 publications

References 22 publications

Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials

Roseoloviruses in transplant recipients: clinical consequences and prospects for treatment and prevention trials

Active human herpesvirus infections in adults with systemic lupus erythematosus and correlation with the SLEDAI score

Betaherpesvirus (Cmv, Hhv-6 and Hhv-7) Active Infections in Brazilian Hematopoietic Stem Cell Transplant Patients

Contact Info

Product

Resources

About