Human herpesvirus 6.

Braun, Daniel; Dominguez, Geraldina; Pellett, Philip E.

doi:10.1128/cmr.10.3.521-567.1997

Cited by 5 publications

(9 citation statements)

References 439 publications

(915 reference statements)

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“…In terms of serological classification, the evidence for a single population would appear to represent a putative seropositive population. This interpretation is consistent with the prior knowledge that HHV-6 and VZV are usually acquired during childhood and more than 95% of the adult populations typically shows evidence of antibody positivity against these viruses [47]. In addition, the core values of these distributions are higher than the cutoff for seropositivity suggested by the lab protocol.…”

Section: Analysis Of Serological Data By Finite Models Based On Smsnsupporting

confidence: 90%

Analysis of antibody data using Finite Mixture Models based on Scale Mixtures of Skew-Normal distributions

Domingues

Mouriño²,

Sepúlveda³

2021

Preprint

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Finite mixture models have been widely used in antibody (or serological) data analysis in order to help classifying individuals into either antibody-positive or antibody-negative. The most popular models are the so-called Gaussian mixture models which assume a Normal distribution for each component of a mixture. In this work, we propose the use of finite mixture models based on a flexible class of scale mixtures of Skew-Normal distributions for serological data analysis. These distributions are sufficiently flexible to describe right and left asymmetry often observed in the distributions associated with hypothetical antibody-negative and antibody-positive individuals, respectively. We illustrate the advantage of these alternative mixture models with a data set of 406 individuals in which antibodies against six different human herpesviruses were measured in the context of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

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Section: Analysis Of Serological Data By Finite Models Based On Smsnsupporting

confidence: 90%

Analysis of antibody data using Finite Mixture Models based on Scale Mixtures of Skew-Normal distributions

Domingues

Mouriño²,

Sepúlveda³

2021

Preprint

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“…There are many causes of liver dysfunction in allogeneic SCT recipients and we could find no relationship between HHV‐6 DNA levels and the degree of liver dysfunction in the patient cohort. However, HHV‐6 has been associated with liver dysfunction in liver transplant patients (Herbein et al , 1996; Lautenschlager et al , 1998) and fulminant hepatitis in children (Braun et al , 1997). Further studies of HHV‐6 as a potential liver pathogen after allogeneic SCT are warranted.…”

Section: Discussionmentioning

confidence: 99%

“…Human herpesvirus 6 (HHV‐6) is a ubiquitous virus and more than 90% of the healthy population over 2 years of age is seropositive (Braun et al , 1997). HHV‐6 isolates can be separated into two closely related and distinct groups designated HHV‐6 variant A and variant B.…”

mentioning

confidence: 99%

“…HHV‐6 isolates can be separated into two closely related and distinct groups designated HHV‐6 variant A and variant B. Primary infection with HHV‐6 variant B causes exanthem subitum (roseola infantum) in infants, while the role of HHV‐6 variant A in disease has not been defined (Yamanishi et al , 1988; Braun et al , 1997). Monitoring of stem cell transplant (SCT) patients by polymerase chain reaction (PCR) or antigenaemia for cytomegalovirus (CMV) has been introduced as routine practice at many transplant centres.…”

mentioning

confidence: 99%

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High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients

et al. 2000

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Summary. The aim of this study was to correlate human herpesvirus (HHV)-6 viral load with clinical symptoms in allogeneic stem cell transplant (SCT) patients. Seventy-four patients were monitored during the first 3 months after SCT using a qualitative polymerase chain reaction (PCR) for HHV-6 DNA. HHV-6 was detected in 181 out of 494 samples (36%) from 58 (78%) patients. These 181 samples were analysed using a quantitative competitive PCR. DNA could be quantified from 146 out of 181 samples (80´6%). The HHV-6 viral load was highest at 4 weeks compared with 8 weeks (P , 0´001) and 12 weeks (P 0´01) after SCT. Three patients had HHV-6 encephalitis and one patient had hepatitis. The HHV-6 DNA levels were higher in patients with HHV-6 than in those without HHV-6 (P 0´01). Patients who received grafts from unrelated or HLA-mismatched family donors had significantly higher HHV-6 DNA levels than patients who received grafts from matched sibling donors (P , 0´001). In a multiple regression model, unrelated donor grafts (P , 0´001) and use of intravenous immunoglobulin prophylaxis (P 0´04) influenced HHV-6 DNA levels. HHV-6 viral load was significantly correlated with delayed platelet engraftment in both univariate (P , 0´01) and multivariate analysis, and to the number of platelet transfusions.

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“…As incidence of HHV-6 specific IgG class antibodies in the adult population is almost 100% (Braun et al, 1997), they cannot be used to differentiate between remote and persistent infection. Furthermore, kits for determination of HHV-6 IgM class antibodies, which would allow determining presence of an active infection, were not commercially available, when the doctoral thesis was written, therefore, the antibodies were not determined.…”

Section: Determination Of Hhv-6 and Hhv-7 Specific Antibodies (Elisa)mentioning

confidence: 99%

Involvement of Latent/Persistent Parvovirus B19, HHV-6 and HHV-7 Infections in Ethiopathogenesis of Rheumatoid Arthritis and Relationship with Clinical and Radiological Findings. Summary of the Doctoral Thesis

Kadisa¹

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Human herpesvirus 6.

Cited by 5 publications

References 439 publications

Analysis of antibody data using Finite Mixture Models based on Scale Mixtures of Skew-Normal distributions

Analysis of antibody data using Finite Mixture Models based on Scale Mixtures of Skew-Normal distributions

High levels of human herpesvirus 6 DNA in peripheral blood leucocytes are correlated to platelet engraftment and disease in allogeneic stem cell transplant patients

Involvement of Latent/Persistent Parvovirus B19, HHV-6 and HHV-7 Infections in Ethiopathogenesis of Rheumatoid Arthritis and Relationship with Clinical and Radiological Findings. Summary of the Doctoral Thesis

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