Human herpes virus type 6 (HHV-6) and its in vitro effect on human immunodeficiency virus (HIV).

Pietroboni, Glenys R.; Harnett, Gerald B.; Farr, T. J.; Bucens, Marion R.

doi:10.1136/jcp.41.12.1310

Cited by 33 publications

(21 citation statements)

References 10 publications

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“…It has been reported recently that HHV-6 may be a cofactor in AIDS because this virus trans-activates the HIV genome (Pietroboni et al, 1988;Ensoli et al, 1989;Horvat et al, 1989;Lusso et al, 1989). From our data, HHV-6 has a tropism for not only T cells but also monocytes/macrophages, as does HIV.…”

Section: Discussionsupporting

confidence: 67%

Latent human herpesvirus 6 infection of human monocytes/macrophages

Kondo

Kondo²,

Okuno

et al. 1991

Journal of General Virology

317

208

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Human herpesvirus 6 (HHV-6) DNA was detected in peripheral blood from exanthem subitum patients during the acute and convalescent phases of infection using the polymerase chain reaction. Although DNA could be detected in non-adherent and adherent mononuclear cells during the acute phase, it was detected predominantly in adherent cells during the convalescent phase; furthermore, viral DNA was found in adherent cells of healthy adults. When adherent mononuclear cells were cultured in vitro, virus was found to replicate well in differentiated cells cultured for 7 days in vitro before infection. When cells were cultured for more than 1 month, no detectable antigen and no evidence of virus growth was observed, but viral DNA could be detected. These apparently latently infected monocytes were treated with phorbol ester, after which virus could be recovered from the cultures. Therefore, we have developed an in vitro latency system for HHV-6; our results suggest that HHV-6 may latently infect monocytes in vivo and in vitro and that it may be reactivated in cells by some factors.

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Section: Discussionsupporting

confidence: 67%

Latent human herpesvirus 6 infection of human monocytes/macrophages

Kondo

Kondo²,

Okuno

et al. 1991

Journal of General Virology

317

208

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“…HHV-6 persists in the cervical lymphnodes of normal adults as well as patients with necrotizing lymphoadenitis (7) and it is reactivated in immunosuppressed renal transplant recipients (22). HHV-6 has been recovered from the saliva of healthy adults (9,15,23). In fact, HHV-6 genomes are detectable by polymerase chain reaction in throat swabs of asymptomatic individuals (8,11).…”

mentioning

confidence: 97%

Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

Linhares

Eizuru

Tateno

et al. 1991

Microbiology and Immunology

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The seroprevalence of human herpesvirus 6 (HHV-6) infection was examined for 434 Brazilians and 250 Japanese immigrants living in Recife and its vicinity, in the North-East of Brazil.A total of 684 sera from the healthy individuals were screened for IgG antibodies to HHV-6 by anticomplement immunofluorescence (ACIF) test. The seropositivity rate to HHV-6 showed little difference between the two groups: namely, it was 76.5% for Brazilians and 77.2% for Japanese immigrants. The seropositivity rate was constantly higher in females than in males. The high prevalence of anti-HHV-6antibodies among children indicates that HHV-6 infection occurs very early in life.

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“…The virus is predominantly trophic and cytopathic for CD4+ T lymphocytes in vitro. Coinfection of CD4+ cells by HHV-6 and human immunodeficiency virus (HIV) leads to enhanced cell degeneration, but the in vivo effects of HHV-6 in HIV-infected persons are unknown (6,11). It has been suggested that dual infection with HHV-6 and HIV may aggravate the HIV-induced immunodeficiency (6), but other coinfection experiments indicate that HHV-6 replication can inhibit the growth of HIV in lymphocytes and produce false-negative HIV culture results (11).…”

mentioning

confidence: 99%

Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) and other antiviral compounds

Akesson-Johansson

Harmenberg

Wahrén

et al. 1990

Antimicrob Agents Chemother

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The in vitro susceptibilities of human herpesvirus 6 to foscarnet; the guanosine analogs acyclovir, ganciclovir, and two isomers of 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine; and the thymidine analogs 3'-azido-3'-deoxythymidine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil were investigated. All compounds except 3'-azido-3'-deoxythymidine and 1-beta-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil inhibited human herpesvirus 6 replication. The highest in vitro selectivity was obtained for 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine.

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Human herpes virus type 6 (HHV-6) and its in vitro effect on human immunodeficiency virus (HIV).

Cited by 33 publications

References 10 publications

Latent human herpesvirus 6 infection of human monocytes/macrophages

Latent human herpesvirus 6 infection of human monocytes/macrophages

Seroprevalence of Human Herpesvirus 6 Infection in Brazilian and Japanese Populations in the North‐East of Brazil

Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) and other antiviral compounds

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