Human herpes virus 8‐unrelated primary effusion lymphoma‐like lymphoma: report of a rare case and review of the literature

Adiguzel, Cafer; Bozkurt, Süheyla; Kaygusuz, Işık; Uzay, Ant; Tecimer, Tülay; Bayık, Mahmut

doi:10.1111/j.1600-0463.2008.00005.x

Cited by 58 publications

(60 citation statements)

References 32 publications

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“…The mean survival time of PEL is approximately 4-6 months; however, in the review of Adiguzel et al [4] of 31 cases of HHV-8-negative effusion lymphoma, the mean survival time was 10.1 months and the mean follow-up period of 13 living patients was 19.5 months [4]. In our two cases, the tumor regressed without any treatment other than drainage of the effusion, and 7 cases of HHV-8-negative effusion lymphoma presenting a similar phenomenon have been reported in the literature [4,5,6,7,8,10]. In 5 cases (including our 2 cases) of these 9 cases, lymphoma cells were involved in the pericardial effusion.…”

Section: Discussionmentioning

confidence: 99%

“…The characteristics of our cases are in excellent agreement with these characteristics. Kobayashi et al [2] found no association between HHV-8-negative effusion lymphoma and hepatitis B virus (HBV)/hepatitis C virus (HCV) infection, although other authors argued that a substantial number of HHV-8-negative cases were HCV positive [3,4,9]. …”

Section: Discussionmentioning

confidence: 99%

“…Such cases have been largely reported from Japan and have been designated ‘HHV-8-negative PEL' or ‘PEL-like lymphoma' [2,3,4,5,6,7,8]. However, the clinical and biological characteristics of these tumors differ from those of PEL.…”

Section: Introductionmentioning

confidence: 99%

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Self-Limited Effusion Large B-Cell Lymphoma: Two Cases of Effusion Lymphoma Maintaining Remission after Drainage Alone

Nakatsuka¹,

Kimura²,

Nagano³

et al. 2013

Acta Haematol

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We report two cases of human herpesvirus-8 (HHV-8)-negative large B-cell lymphoma involving pericardial and/or pleural effusion that regressed after drainage alone. Case 1 is a 70-year-old man showing massive pericardial effusion. Cytology of the drained effusion showed monotonous infiltration of CD3-, CD20+, CD79a+, and CD138- large B-cells. Monoclonality was shown by Southern blot analysis. Case 2 is a 70-year-old man with massive pericardial and bilateral pleural effusion. Cytology of pericardial effusion showed infiltration of CD20+, CD45RO-, CD138-, immunoglobulin lambda chain+, and kappa chain- large B cells. In both cases, effusion resolved after drainage and no relapse has been observed. HHV-8 was not demonstrated in either case. Clinical presentation of our two cases resembled primary effusion lymphoma (PEL), but cytomorphology, immunophenotype, and prognosis were clearly distinct from those of PEL. HHV-8-negative effusion lymphomas might include prognostically favorable self-limited tumors that could regress without any cytotoxic therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Self-Limited Effusion Large B-Cell Lymphoma: Two Cases of Effusion Lymphoma Maintaining Remission after Drainage Alone

Nakatsuka¹,

Kimura²,

Nagano³

et al. 2013

Acta Haematol

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“…On the other hand, it has been reported that HHV-8-negative PEL highly expresses B-cell markers, called PEL-like lymphoma [4]. It has also been reported that the malignant cells of HHV-8-unrelated HIV-negative PEL-like lymphoma patients disappear spontaneously without chemotherapy after serous effusion aspiration or drainage [3,[5][6][7][8]. We report two cases of HHV-8-unrelated HIV-negative PEL-like lymphoma in whom no malignant cells were present after effusion drainage alone.…”

Section: Introductionmentioning

confidence: 95%

“…The malignant cells are usually negative for B-cell markers, such as CD19, CD20, and CD79a, but are positive for activation and plasma cell-related markers, such as CD30, CD38, and CD138. The median survival of patients with PEL is \6 months [2,3]. On the other hand, it has been reported that HHV-8-negative PEL highly expresses B-cell markers, called PEL-like lymphoma [4].…”

Section: Introductionmentioning

confidence: 98%

Disappearance of malignant cells by effusion drainage alone in two patients with HHV-8-unrelated HIV-negative primary effusion lymphoma-like lymphoma

et al. 2011

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Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin lymphoma usually confined to the body cavities of predominantly immunosuppressed patients infected with human herpes virus-8 (HHV-8). In PEL, malignant cells are usually negative for B-cell markers, such as CD19, CD20, and CD79a, but are positive for activation and plasma cell-related markers, such as CD30, CD38, and CD138. It has been reported that HHV-8-unrelated PEL shows high expression of B-cell markers, which is referred to as PEL-like lymphoma. Here, we report two cases of HHV-8-unrelated HIV-negative PEL-like lymphoma in which malignant cells regressed spontaneously after effusion drainage alone. These cells expressed B-cell markers, such as CD20. No chemotherapy was given to either patient, as they were of an advanced age, and both achieved a complete response by effusion drainage alone. One showed a complete response for 16 months after effusion drainage, and the other has survived for 11 months with a complete response. This suggests that sufficient drainage of serous effusion may induce and maintain a complete response in some patients with HHV-8-unrelated HIV-negative PEL-like lymphoma, which represents an excellent treatment option for elderly patients with this disease.

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HIV‐negative, HHV‐8‐unrelated primary effusion lymphoma‐like lymphoma: report of two cases

et al. 2009

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Sickle-cell disease is not a reportable condition, making it difficult to ascertain the number of affected individuals. We estimated the number of people with sickle-cell disease for the United States and each individual state, adjusting for increased mortality. US Census population data for each of the 50 states plus the District of Columbia were obtained. The published prevalence of sickle-cell disease for blacks and Hispanics of either Mexican or non-Mexican ancestry was applied. Analysis revealed 89,079 (95% confidence interval: 88,494-89,664) people with sickle-cell disease in the United States, 80,151 black and 8928 Hispanic. The state with the highest sickle-cell population was New York with 8308, followed by Florida with 7539, and Texas with 6765 people with sickle-cell disease. This study provides important information for researchers and policymakers attempting to better plan for the care of the sickle-cell population. Sickle-cell disease is the most common inherited blood disorder in the United States. It is responsible for approximately 113,000 hospitalizations and $488 million dollars in hospitalization costs annually in the United States [1]. Although sickle-cell disease is a genetic disease diagnosed in this era by newborn screening, it is not a reportable condition. Therefore, it is difficult to ascertain the number of affected individuals in the United States. Newborn screening is an effective tool for diagnosis, but its use was not widespread until the late 1980s and 1990s [2], and it does not account for immigration. Further complicating population estimates is the increased mortality associated with the disease, both compared to the mortality for the underlying racial/ethnic group and when comparing more severe forms of the disease (hemoglobin SS (HgbSS) and hemoglobin S beta thalessemia (HgbSB 0)) to less severe forms of the disease (hemoglobin SC (HgbSC) and HgbSB 1) [3-7]. Recent advances such as prophylactic penicillin and vaccines have reduced mortality, but only for those young enough to have received the treatments [8,9]. While no published studies have estimated the prevalence of sickle-cell disease in the United States, one NIH estimate puts the number ''between 50,000 and 75,000;'' another at 80,000, and the Sickle Cell Disease Association of America estimates the number to be ''over 70,000'' [10-12] Methods Census level-data and prevalence. Census data by age and race/ethnicity were obtained for each individual state and the District of Columbia and summed to equal the United States as a whole [13]. Year 2005 was used as the baseline. The applied prevalence rate of sickle-cell disease for blacks was 289 per 100,000 live births [14]. Prevalence rates for Hispanics were 89.8 Hispanic children of non-Mexican ancestry per 100,000 live births and 3.14 Hispanic children of Mexican ancestry per 100,000 live births [14]. These prevalence rates were applied to the Hispanic population numbers in each state based on the state's ratio of the number of Mexican births to non-Mexican births, assum...

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Human herpes virus 8‐unrelated primary effusion lymphoma‐like lymphoma: report of a rare case and review of the literature

Cited by 58 publications

References 32 publications

Self-Limited Effusion Large B-Cell Lymphoma: Two Cases of Effusion Lymphoma Maintaining Remission after Drainage Alone

Self-Limited Effusion Large B-Cell Lymphoma: Two Cases of Effusion Lymphoma Maintaining Remission after Drainage Alone

Disappearance of malignant cells by effusion drainage alone in two patients with HHV-8-unrelated HIV-negative primary effusion lymphoma-like lymphoma

HIV‐negative, HHV‐8‐unrelated primary effusion lymphoma‐like lymphoma: report of two cases

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